Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3495 |
Resumo: | Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and compounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis. |
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Silva, Bruno José Martins daHage, Amanda Anastácia PintoSilva, Edilene OliveiraRodrigues, Ana Paula Drummond2018-10-05T16:06:01Z2018-10-05T16:06:01Z2018SILVA, Bruno José Martins da et al. Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review. Journal of integrative medicine, v. 16, n. 4, p. 211-222, July 2018. DOI: https://doi.org/ 10.1016/j.joim.2018.04.0042095-4964https://patua.iec.gov.br/handle/iec/349510.1016/j.joim.2018.04.004Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and compounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis.Federal University of Pará. Institute of Biological Sciences. Laboratory of Parasitology and Laboratory of Structural Biology. Belém, PA, Brazil / National Institute of Science and Technology in Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Parasitology and Laboratory of Structural Biology. Belém, PA, Brazil / National Institute of Science and Technology in Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Parasitology and Laboratory of Structural Biology. Belém, PA, Brazil / National Institute of Science and Technology in Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil.National Institute of Science and Technology in Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Ananindeua, PA, Brasil.engElsevierMedicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmaniose / parasitologiaPlantas Medicinais / efeitos dos fármacosExtratos Vegetais / uso terapêuticoÓleos Vegetais / uso terapêuticoinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAcesso Embargado.pdfAcesso Embargado.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/1220c2d8-fc29-474f-aef0-20141da89b35/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/7d044ebe-b966-4263-8bf5-6635f0847ab7/download52f1732ea66fbd1123abe39f5373b797MD52TEXTMedicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review.pdf.txtMedicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/755d2272-2fce-4c3d-9cce-971b55e12e6a/downloade1c06d85ae7b8b032bef47e42e4c08f9MD55Acesso Embargado.pdf.txtAcesso Embargado.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/3201c35f-227f-4416-9972-ecf72384eb0d/downloade1c06d85ae7b8b032bef47e42e4c08f9MD57THUMBNAILMedicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review.pdf.jpgMedicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/a2038886-71c9-4a49-a09b-6fef1ede47d6/download71859d578212107f7f8c49a4ce09d9eeMD56Acesso Embargado.pdf.jpgAcesso Embargado.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/ae5eac30-0f55-424c-b9f8-489b4380b8b8/download71859d578212107f7f8c49a4ce09d9eeMD58iec/34952023-05-22 18:17:48.278oai:patua.iec.gov.br:iec/3495https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-05-22T18:17:48Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review |
title |
Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review |
spellingShingle |
Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review Silva, Bruno José Martins da Leishmaniose / parasitologia Plantas Medicinais / efeitos dos fármacos Extratos Vegetais / uso terapêutico Óleos Vegetais / uso terapêutico |
title_short |
Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review |
title_full |
Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review |
title_fullStr |
Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review |
title_full_unstemmed |
Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review |
title_sort |
Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review |
author |
Silva, Bruno José Martins da |
author_facet |
Silva, Bruno José Martins da Hage, Amanda Anastácia Pinto Silva, Edilene Oliveira Rodrigues, Ana Paula Drummond |
author_role |
author |
author2 |
Hage, Amanda Anastácia Pinto Silva, Edilene Oliveira Rodrigues, Ana Paula Drummond |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Bruno José Martins da Hage, Amanda Anastácia Pinto Silva, Edilene Oliveira Rodrigues, Ana Paula Drummond |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Leishmaniose / parasitologia Plantas Medicinais / efeitos dos fármacos Extratos Vegetais / uso terapêutico Óleos Vegetais / uso terapêutico |
topic |
Leishmaniose / parasitologia Plantas Medicinais / efeitos dos fármacos Extratos Vegetais / uso terapêutico Óleos Vegetais / uso terapêutico |
description |
Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and compounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-10-05T16:06:01Z |
dc.date.available.fl_str_mv |
2018-10-05T16:06:01Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Bruno José Martins da et al. Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review. Journal of integrative medicine, v. 16, n. 4, p. 211-222, July 2018. DOI: https://doi.org/ 10.1016/j.joim.2018.04.004 |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3495 |
dc.identifier.issn.-.fl_str_mv |
2095-4964 |
dc.identifier.doi.-.fl_str_mv |
10.1016/j.joim.2018.04.004 |
identifier_str_mv |
SILVA, Bruno José Martins da et al. Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review. Journal of integrative medicine, v. 16, n. 4, p. 211-222, July 2018. DOI: https://doi.org/ 10.1016/j.joim.2018.04.004 2095-4964 10.1016/j.joim.2018.04.004 |
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https://patua.iec.gov.br/handle/iec/3495 |
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eng |
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Elsevier |
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Elsevier |
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