Oral treatment with the extract of Euterpe oleracea Mart. improves motor dysfunction and reduces brain injury in rats subjected to ischemic stroke

• Autor(a) principal: Teixeira, Leonan Lima
• Data de Publicação: 2023
• Outros Autores: Alencar, Helma Maria Negrão da Silva, Ferreira, Luan Oliveira, Rodrigues, João Cleiton Martins, Souza, Rafael Dias de, Pinto, Laine Celestino, Muto, Nilton Akio, Rogez, Hervé, Martins Filho, Arnaldo Jorge, Mello, Vanessa Joia de, Harmoy, Moises, Costa, Edmar Tavares da, Lopes, Dielly Catrina Favacho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/6752
• topic: Cérebro / lesões; AVC Isquêmico; Extratos Vegetais / uso terapêutico; Euterpe / efeitos dos fármacos

Ischemic stroke is one of the principal causes of morbidity and mortality around the world. The pathophysiological mechanisms that lead to the formation of the stroke lesions range from the bioenergetic failure of the cells and the intense production of reactive oxygen species to neuroinflammation. The fruit of the açaí palm, Euterpe oleracea Mart. (EO), is consumed by traditional populations in the Brazilian Amazon region, and it is known to have antioxidant and anti-inflammatory properties. We evaluated whether the clarified extract of EO was capable of reducing the area of lesion and promoting neuronal survival following ischemic stroke in rats. Animals submitted to ischemic stroke and treated with EO extract presented a significant improvement in their neurological deficit from the ninth day onward. We also observed a reduction in the extent of the cerebral injury and the preservation of the neurons of the cortical layers. Taken together, our findings indicate that treatment with EO extract in the acute phase following a stroke can trigger signaling pathways that culminate in neuronal survival and promote the partial recovery of neurological scores. However, further detailed studies of the intracellular signaling pathways are needed to better understand the mechanisms involved.