Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3064 |
Resumo: | Development of functionalized nanocomposites containing AgNPs-PVP-Glucantime® to evaluate their leishmanicidal activity as a novel method for improving the pharmacological properties of the drug Glucantime® against extracellular promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro to treat cutaneous leishmaniasis. Materials & methods: The silver nanoparticles and nanocomposites prepared containing silver nanoparticles, polyvinylpyrrolidone and different amounts of Glucantime were characterized using transmission electron microscopy, x-ray diffraction, energy-dispersive x-ray spectroscopy and ζ potential analysis; in addition, the in vitro cytotoxicity was evaluated. Results: The nanocomposites showed an inhibitory effect on the cellular viability of promastigote forms, with values of 47.06, 51.71 and 65.67% for nanocomposite1, nanocomposite2 and nanocomposite3, respectively, as well as a dose-dependent decrease in the infectivity index, with values of 33.33 and 23% for nanocomposite2 and nanocomposite3, respectively. Conclusion: The proposed nanocomposite reveals leishmanial activity and the absence of cytotoxicity in macrophages. Further investigations will be conducted in vivo. |
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Gélvez, Ana Patricia CacuaFarias, Luis Henrique SeabraPereira, Victor SoaresSilva, Inaldo Claudio Martins daCosta, Ana CarolinaDias, Carmen Gilda Barroso TavaresCosta, Roseane Maria RibeiroSilva, Silvia Helena Marques daRodrigues, Ana Paula Drummond2018-03-01T13:21:16Z2018-03-01T13:21:16Z2018GÉLVEZ, Ana Patricia Cacua et al. Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime. Nanomedicine, v. 13, n. 4, p. 373-390, 2018. DOI: https://doi.org/10.2217/nnm-2017-0285. 1743-5889https://patua.iec.gov.br/handle/iec/306410.2217/nnm-2017-0285Development of functionalized nanocomposites containing AgNPs-PVP-Glucantime® to evaluate their leishmanicidal activity as a novel method for improving the pharmacological properties of the drug Glucantime® against extracellular promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro to treat cutaneous leishmaniasis. Materials & methods: The silver nanoparticles and nanocomposites prepared containing silver nanoparticles, polyvinylpyrrolidone and different amounts of Glucantime were characterized using transmission electron microscopy, x-ray diffraction, energy-dispersive x-ray spectroscopy and ζ potential analysis; in addition, the in vitro cytotoxicity was evaluated. Results: The nanocomposites showed an inhibitory effect on the cellular viability of promastigote forms, with values of 47.06, 51.71 and 65.67% for nanocomposite1, nanocomposite2 and nanocomposite3, respectively, as well as a dose-dependent decrease in the infectivity index, with values of 33.33 and 23% for nanocomposite2 and nanocomposite3, respectively. Conclusion: The proposed nanocomposite reveals leishmanial activity and the absence of cytotoxicity in macrophages. Further investigations will be conducted in vivo.Federal University of Pará. Postgraduate Program in Biology of Infectious & Parasitic Agents. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório der Microscopia Eletrônica. Ananindeua, PA, Brasil.Escola Superior da Amazônia. Department of Biomedicine. Belém, PA, Brazil.Federal University of Pará,. Department of Mechanical Engineering. Belém, PA, Brazil.Federal University of Pará. Faculty of Chemical Engineering. Belém, PA, Brazil.Federal University of Pará. Physico-Chemical Drug Quality Control Laboratory. Belém, PA, Brazil.Federal University of Pará,. Department of Mechanical Engineering. Belém, PA, Brazil.Federal University of Pará. Physico-Chemical Drug Quality Control Laboratory. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório der Microscopia Eletrônica. Ananindeua, PA, Brasil.engFuture MedicineBiosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantimeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmania / efeitos de drogasNanopartículas / biossínteseLeishmaniose Cutânea / tratamento farmacológicoFármacos DermatológicosTratamento Farmacológicoinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECLICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/77afb0e5-5cc1-42aa-a395-34edb2797bfb/download52f1732ea66fbd1123abe39f5373b797MD52ORIGINALBiosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime.pdfBiosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/634196ba-42f8-4e3d-9b09-018bd8c04903/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD56TEXTBiosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime.pdf.txtBiosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/20c6290f-e8b9-458a-9496-f145e7b9091c/downloade1c06d85ae7b8b032bef47e42e4c08f9MD59THUMBNAILBiosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime.pdf.jpgBiosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/c66ec6c3-2c0f-4c8a-bcf1-b4095698c112/download71859d578212107f7f8c49a4ce09d9eeMD510iec/30642023-06-13 14:26:07.666oai:patua.iec.gov.br:iec/3064https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-06-13T14:26:07Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime |
title |
Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime |
spellingShingle |
Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime Gélvez, Ana Patricia Cacua Leishmania / efeitos de drogas Nanopartículas / biossíntese Leishmaniose Cutânea / tratamento farmacológico Fármacos Dermatológicos Tratamento Farmacológico |
title_short |
Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime |
title_full |
Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime |
title_fullStr |
Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime |
title_full_unstemmed |
Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime |
title_sort |
Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime |
author |
Gélvez, Ana Patricia Cacua |
author_facet |
Gélvez, Ana Patricia Cacua Farias, Luis Henrique Seabra Pereira, Victor Soares Silva, Inaldo Claudio Martins da Costa, Ana Carolina Dias, Carmen Gilda Barroso Tavares Costa, Roseane Maria Ribeiro Silva, Silvia Helena Marques da Rodrigues, Ana Paula Drummond |
author_role |
author |
author2 |
Farias, Luis Henrique Seabra Pereira, Victor Soares Silva, Inaldo Claudio Martins da Costa, Ana Carolina Dias, Carmen Gilda Barroso Tavares Costa, Roseane Maria Ribeiro Silva, Silvia Helena Marques da Rodrigues, Ana Paula Drummond |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gélvez, Ana Patricia Cacua Farias, Luis Henrique Seabra Pereira, Victor Soares Silva, Inaldo Claudio Martins da Costa, Ana Carolina Dias, Carmen Gilda Barroso Tavares Costa, Roseane Maria Ribeiro Silva, Silvia Helena Marques da Rodrigues, Ana Paula Drummond |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Leishmania / efeitos de drogas Nanopartículas / biossíntese Leishmaniose Cutânea / tratamento farmacológico Fármacos Dermatológicos Tratamento Farmacológico |
topic |
Leishmania / efeitos de drogas Nanopartículas / biossíntese Leishmaniose Cutânea / tratamento farmacológico Fármacos Dermatológicos Tratamento Farmacológico |
description |
Development of functionalized nanocomposites containing AgNPs-PVP-Glucantime® to evaluate their leishmanicidal activity as a novel method for improving the pharmacological properties of the drug Glucantime® against extracellular promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro to treat cutaneous leishmaniasis. Materials & methods: The silver nanoparticles and nanocomposites prepared containing silver nanoparticles, polyvinylpyrrolidone and different amounts of Glucantime were characterized using transmission electron microscopy, x-ray diffraction, energy-dispersive x-ray spectroscopy and ζ potential analysis; in addition, the in vitro cytotoxicity was evaluated. Results: The nanocomposites showed an inhibitory effect on the cellular viability of promastigote forms, with values of 47.06, 51.71 and 65.67% for nanocomposite1, nanocomposite2 and nanocomposite3, respectively, as well as a dose-dependent decrease in the infectivity index, with values of 33.33 and 23% for nanocomposite2 and nanocomposite3, respectively. Conclusion: The proposed nanocomposite reveals leishmanial activity and the absence of cytotoxicity in macrophages. Further investigations will be conducted in vivo. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-03-01T13:21:16Z |
dc.date.available.fl_str_mv |
2018-03-01T13:21:16Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GÉLVEZ, Ana Patricia Cacua et al. Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime. Nanomedicine, v. 13, n. 4, p. 373-390, 2018. DOI: https://doi.org/10.2217/nnm-2017-0285. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3064 |
dc.identifier.issn.-.fl_str_mv |
1743-5889 |
dc.identifier.doi.-.fl_str_mv |
10.2217/nnm-2017-0285 |
identifier_str_mv |
GÉLVEZ, Ana Patricia Cacua et al. Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime. Nanomedicine, v. 13, n. 4, p. 373-390, 2018. DOI: https://doi.org/10.2217/nnm-2017-0285. 1743-5889 10.2217/nnm-2017-0285 |
url |
https://patua.iec.gov.br/handle/iec/3064 |
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eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.publisher.none.fl_str_mv |
Future Medicine |
publisher.none.fl_str_mv |
Future Medicine |
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IEC |
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