Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon

• Autor(a) principal: Oliveira, Consuelo Silva de
• Data de Publicação: 2020
• Outros Autores: Matos, Haroldo José de, Ramos, Francisco Lúzio de Paula, Pinto, Ana Yecê das Neves, Graim, Priscila Nathyelly dos S, Guimarães, Vivianne de Paula R, Gomes, Luna Thaís S, Serra, Emilene M. F, Cruz, Ana Cecília Ribeiro, Leal, Alessandra, Henriques, Daniele Freitas, Lima, Juliana A, Anjos, Maura Viana dos, Pinto, Eliana Vieira Pinto da, Sousa, Alana Watanabe de, Vasconcelos, Pedro Fernando da Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: http://patua.iec.gov.br//handle/iec/4177
• topic: Zika virus / patogenicidade; Infecção por Zika virus; Microcefalia / genética; Gravidez; Complicações na Gravidez

Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará, Brazil, from October 2015 to December 2017. Results. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation. Conclusions. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/ or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection.