Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/6815 |
Resumo: | Introduction: COVID-19 in Brazil has already caused, and it still causes, several impacts on health, economy, and education. The risk factors for death involved those with cardiovascular diseases (CVD), which were prioritized for the vaccination of COVID-19. Objective: To investigate the clinical characteristics and outcomes between vaccinated and unvaccinated patients with cardiovascular diseases hospitalized for COVID-19 in Brazil in the year 2022. Methods: A retrospective cohort was analyzed from the year 2022, with cases being hospitalized by COVID-19 being drawn from SIVEP-GRIPE surveillance. We compared clinical characteristics, comorbidities, and outcomes between CVD carriers and non-carriers, and we also compared vaccinated with two doses vs. those that are unvaccinated in CVD carriers. We performed chi-square, odds ratio, logistic regression, and survival analysis. Results: We included, in the cohort, 112,459 hospital inpatients. An amount of 71,661 (63.72%) of the hospitalized patients had CVD. Regarding deaths, 37,888 (33.69%) died. Regarding vaccination against COVID-19, 20,855 (18.54%) people were not vaccinated with any dose among those with CVD. Death p- < 0.001 (OR 1.307-CI 1.235-1.383) and fever p- < 0.001 (OR 1.156-CI 1.098-1.218) were associated with the unvaccinated CVD carriers, and diarrhea p-0.015 (OR 1.116-CI 1.022-1.218), dyspnea p-0.022 (OR 1.074-CI 1.011-1.142), and respiratory distress p-0.021 (OR 1.070-CI 1.011-1.134) were also recorded. Those patients who possessed predictors of death, including invasive ventilation (p- < 0.001 (OR 8.816-CI 8.313-9.350)), were admitted to the ICU p- < 0.001 (OR 1.754-CI 1.684-1.827), and some had respiratory distress p- < 0.001 (OR 1.367-CI 1.312-1.423), dyspnea p < 0.001 (OR 1.341-CI 1.284-1.400), O2 saturation < 95% p- < 0. 001 (OR 1.307-CI 1.254-1.363), they were unvaccinated against COVID-19 p- < 0.001 (OR 1.258-CI 1.200-1.319), they were of male sex p- < 0.001 (OR 1.179-CI 1.138-1.221), they had diarrhea p-0.018 (OR 1.081-CI 1.013-1.154), and they may have been old p < 0.001 (OR 1.034-CI 1.033-1.035). Survival was shorter for the unvaccinated p-0.003, and p- <0.001. Conclusions: We highlight the predictors of death for those unvaccinated against COVID-19 in this research, and we evidenced the benefits of the COVID-19 vaccine in reducing deaths in hospitalized CVD patients. |
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Sardinha, Daniele MeloFerreira, Ana Lúcia da SilvaGuimarães, Ricardo José de Paula Souza eLima, Karla Valéria BatistaLima, Luana Nepomuceno Gondim Costa2023-05-08T12:34:26Z2023-05-08T12:34:26Z2023SARDINHA, Daniele Melo et al. Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort. Vaccines, v. 11, n. 4, p. 1-21, Apr. 2023. DOI: https://doi.org/10.3390/vaccines11040861. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146801/pdf/vaccines-11-00861.pdf.2076-393Xhttps://patua.iec.gov.br/handle/iec/681510.3390/vaccines11040861.Introduction: COVID-19 in Brazil has already caused, and it still causes, several impacts on health, economy, and education. The risk factors for death involved those with cardiovascular diseases (CVD), which were prioritized for the vaccination of COVID-19. Objective: To investigate the clinical characteristics and outcomes between vaccinated and unvaccinated patients with cardiovascular diseases hospitalized for COVID-19 in Brazil in the year 2022. Methods: A retrospective cohort was analyzed from the year 2022, with cases being hospitalized by COVID-19 being drawn from SIVEP-GRIPE surveillance. We compared clinical characteristics, comorbidities, and outcomes between CVD carriers and non-carriers, and we also compared vaccinated with two doses vs. those that are unvaccinated in CVD carriers. We performed chi-square, odds ratio, logistic regression, and survival analysis. Results: We included, in the cohort, 112,459 hospital inpatients. An amount of 71,661 (63.72%) of the hospitalized patients had CVD. Regarding deaths, 37,888 (33.69%) died. Regarding vaccination against COVID-19, 20,855 (18.54%) people were not vaccinated with any dose among those with CVD. Death p- < 0.001 (OR 1.307-CI 1.235-1.383) and fever p- < 0.001 (OR 1.156-CI 1.098-1.218) were associated with the unvaccinated CVD carriers, and diarrhea p-0.015 (OR 1.116-CI 1.022-1.218), dyspnea p-0.022 (OR 1.074-CI 1.011-1.142), and respiratory distress p-0.021 (OR 1.070-CI 1.011-1.134) were also recorded. Those patients who possessed predictors of death, including invasive ventilation (p- < 0.001 (OR 8.816-CI 8.313-9.350)), were admitted to the ICU p- < 0.001 (OR 1.754-CI 1.684-1.827), and some had respiratory distress p- < 0.001 (OR 1.367-CI 1.312-1.423), dyspnea p < 0.001 (OR 1.341-CI 1.284-1.400), O2 saturation < 95% p- < 0. 001 (OR 1.307-CI 1.254-1.363), they were unvaccinated against COVID-19 p- < 0.001 (OR 1.258-CI 1.200-1.319), they were of male sex p- < 0.001 (OR 1.179-CI 1.138-1.221), they had diarrhea p-0.018 (OR 1.081-CI 1.013-1.154), and they may have been old p < 0.001 (OR 1.034-CI 1.033-1.035). Survival was shorter for the unvaccinated p-0.003, and p- <0.001. Conclusions: We highlight the predictors of death for those unvaccinated against COVID-19 in this research, and we evidenced the benefits of the COVID-19 vaccine in reducing deaths in hospitalized CVD patients.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Instituto Evandro Chagas (IEC) and Fundação Amazônia de Amparo an Estudos e Pesquisas (FAPESPA). The project was financed by the edict number 013/2021.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Geoprocessamento. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Geoprocessamento. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. 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dc.title.pt_BR.fl_str_mv |
Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort |
title |
Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort |
spellingShingle |
Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort Sardinha, Daniele Melo COVID-19 SARS-CoV-2 / patogenicidade Vacinação / estatística & dados numéricos Cardiopatias Congênitas Fatores de Risco de Doenças Cardíacas Estudos de Coortes |
title_short |
Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort |
title_full |
Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort |
title_fullStr |
Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort |
title_full_unstemmed |
Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort |
title_sort |
Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort |
author |
Sardinha, Daniele Melo |
author_facet |
Sardinha, Daniele Melo Ferreira, Ana Lúcia da Silva Guimarães, Ricardo José de Paula Souza e Lima, Karla Valéria Batista Lima, Luana Nepomuceno Gondim Costa |
author_role |
author |
author2 |
Ferreira, Ana Lúcia da Silva Guimarães, Ricardo José de Paula Souza e Lima, Karla Valéria Batista Lima, Luana Nepomuceno Gondim Costa |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sardinha, Daniele Melo Ferreira, Ana Lúcia da Silva Guimarães, Ricardo José de Paula Souza e Lima, Karla Valéria Batista Lima, Luana Nepomuceno Gondim Costa |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 / patogenicidade Vacinação / estatística & dados numéricos Cardiopatias Congênitas Fatores de Risco de Doenças Cardíacas Estudos de Coortes |
topic |
COVID-19 SARS-CoV-2 / patogenicidade Vacinação / estatística & dados numéricos Cardiopatias Congênitas Fatores de Risco de Doenças Cardíacas Estudos de Coortes |
description |
Introduction: COVID-19 in Brazil has already caused, and it still causes, several impacts on health, economy, and education. The risk factors for death involved those with cardiovascular diseases (CVD), which were prioritized for the vaccination of COVID-19. Objective: To investigate the clinical characteristics and outcomes between vaccinated and unvaccinated patients with cardiovascular diseases hospitalized for COVID-19 in Brazil in the year 2022. Methods: A retrospective cohort was analyzed from the year 2022, with cases being hospitalized by COVID-19 being drawn from SIVEP-GRIPE surveillance. We compared clinical characteristics, comorbidities, and outcomes between CVD carriers and non-carriers, and we also compared vaccinated with two doses vs. those that are unvaccinated in CVD carriers. We performed chi-square, odds ratio, logistic regression, and survival analysis. Results: We included, in the cohort, 112,459 hospital inpatients. An amount of 71,661 (63.72%) of the hospitalized patients had CVD. Regarding deaths, 37,888 (33.69%) died. Regarding vaccination against COVID-19, 20,855 (18.54%) people were not vaccinated with any dose among those with CVD. Death p- < 0.001 (OR 1.307-CI 1.235-1.383) and fever p- < 0.001 (OR 1.156-CI 1.098-1.218) were associated with the unvaccinated CVD carriers, and diarrhea p-0.015 (OR 1.116-CI 1.022-1.218), dyspnea p-0.022 (OR 1.074-CI 1.011-1.142), and respiratory distress p-0.021 (OR 1.070-CI 1.011-1.134) were also recorded. Those patients who possessed predictors of death, including invasive ventilation (p- < 0.001 (OR 8.816-CI 8.313-9.350)), were admitted to the ICU p- < 0.001 (OR 1.754-CI 1.684-1.827), and some had respiratory distress p- < 0.001 (OR 1.367-CI 1.312-1.423), dyspnea p < 0.001 (OR 1.341-CI 1.284-1.400), O2 saturation < 95% p- < 0. 001 (OR 1.307-CI 1.254-1.363), they were unvaccinated against COVID-19 p- < 0.001 (OR 1.258-CI 1.200-1.319), they were of male sex p- < 0.001 (OR 1.179-CI 1.138-1.221), they had diarrhea p-0.018 (OR 1.081-CI 1.013-1.154), and they may have been old p < 0.001 (OR 1.034-CI 1.033-1.035). Survival was shorter for the unvaccinated p-0.003, and p- <0.001. Conclusions: We highlight the predictors of death for those unvaccinated against COVID-19 in this research, and we evidenced the benefits of the COVID-19 vaccine in reducing deaths in hospitalized CVD patients. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-05-08T12:34:26Z |
dc.date.available.fl_str_mv |
2023-05-08T12:34:26Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SARDINHA, Daniele Melo et al. Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort. Vaccines, v. 11, n. 4, p. 1-21, Apr. 2023. DOI: https://doi.org/10.3390/vaccines11040861. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146801/pdf/vaccines-11-00861.pdf. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/6815 |
dc.identifier.issn.-.fl_str_mv |
2076-393X |
dc.identifier.doi.pt_BR.fl_str_mv |
10.3390/vaccines11040861. |
identifier_str_mv |
SARDINHA, Daniele Melo et al. Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort. Vaccines, v. 11, n. 4, p. 1-21, Apr. 2023. DOI: https://doi.org/10.3390/vaccines11040861. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146801/pdf/vaccines-11-00861.pdf. 2076-393X 10.3390/vaccines11040861. |
url |
https://patua.iec.gov.br/handle/iec/6815 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
institution |
IEC |
reponame_str |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
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bitstream.checksum.fl_str_mv |
ebe7811bf7869a6f62012c7e5be9796a 11832eea31b16df8613079d742d61793 d2a6447c61b323751935d16ba45ce6ec d2a6447c61b323751935d16ba45ce6ec 6b2adbfae1e9f951e9a55b6760fe8525 6b2adbfae1e9f951e9a55b6760fe8525 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC) |
repository.mail.fl_str_mv |
clariceneta@iec.gov.br || Biblioteca@iec.gov.br |
_version_ |
1809190035393609728 |