Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort

Detalhes bibliográficos
Autor(a) principal: Sardinha, Daniele Melo
Data de Publicação: 2023
Outros Autores: Ferreira, Ana Lúcia da Silva, Guimarães, Ricardo José de Paula Souza e, Lima, Karla Valéria Batista, Lima, Luana Nepomuceno Gondim Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/6815
Resumo: Introduction: COVID-19 in Brazil has already caused, and it still causes, several impacts on health, economy, and education. The risk factors for death involved those with cardiovascular diseases (CVD), which were prioritized for the vaccination of COVID-19. Objective: To investigate the clinical characteristics and outcomes between vaccinated and unvaccinated patients with cardiovascular diseases hospitalized for COVID-19 in Brazil in the year 2022. Methods: A retrospective cohort was analyzed from the year 2022, with cases being hospitalized by COVID-19 being drawn from SIVEP-GRIPE surveillance. We compared clinical characteristics, comorbidities, and outcomes between CVD carriers and non-carriers, and we also compared vaccinated with two doses vs. those that are unvaccinated in CVD carriers. We performed chi-square, odds ratio, logistic regression, and survival analysis. Results: We included, in the cohort, 112,459 hospital inpatients. An amount of 71,661 (63.72%) of the hospitalized patients had CVD. Regarding deaths, 37,888 (33.69%) died. Regarding vaccination against COVID-19, 20,855 (18.54%) people were not vaccinated with any dose among those with CVD. Death p- < 0.001 (OR 1.307-CI 1.235-1.383) and fever p- < 0.001 (OR 1.156-CI 1.098-1.218) were associated with the unvaccinated CVD carriers, and diarrhea p-0.015 (OR 1.116-CI 1.022-1.218), dyspnea p-0.022 (OR 1.074-CI 1.011-1.142), and respiratory distress p-0.021 (OR 1.070-CI 1.011-1.134) were also recorded. Those patients who possessed predictors of death, including invasive ventilation (p- < 0.001 (OR 8.816-CI 8.313-9.350)), were admitted to the ICU p- < 0.001 (OR 1.754-CI 1.684-1.827), and some had respiratory distress p- < 0.001 (OR 1.367-CI 1.312-1.423), dyspnea p < 0.001 (OR 1.341-CI 1.284-1.400), O2 saturation < 95% p- < 0. 001 (OR 1.307-CI 1.254-1.363), they were unvaccinated against COVID-19 p- < 0.001 (OR 1.258-CI 1.200-1.319), they were of male sex p- < 0.001 (OR 1.179-CI 1.138-1.221), they had diarrhea p-0.018 (OR 1.081-CI 1.013-1.154), and they may have been old p < 0.001 (OR 1.034-CI 1.033-1.035). Survival was shorter for the unvaccinated p-0.003, and p- <0.001. Conclusions: We highlight the predictors of death for those unvaccinated against COVID-19 in this research, and we evidenced the benefits of the COVID-19 vaccine in reducing deaths in hospitalized CVD patients.
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spelling Sardinha, Daniele MeloFerreira, Ana Lúcia da SilvaGuimarães, Ricardo José de Paula Souza eLima, Karla Valéria BatistaLima, Luana Nepomuceno Gondim Costa2023-05-08T12:34:26Z2023-05-08T12:34:26Z2023SARDINHA, Daniele Melo et al. Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort. Vaccines, v. 11, n. 4, p. 1-21, Apr. 2023. DOI: https://doi.org/10.3390/vaccines11040861. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146801/pdf/vaccines-11-00861.pdf.2076-393Xhttps://patua.iec.gov.br/handle/iec/681510.3390/vaccines11040861.Introduction: COVID-19 in Brazil has already caused, and it still causes, several impacts on health, economy, and education. The risk factors for death involved those with cardiovascular diseases (CVD), which were prioritized for the vaccination of COVID-19. Objective: To investigate the clinical characteristics and outcomes between vaccinated and unvaccinated patients with cardiovascular diseases hospitalized for COVID-19 in Brazil in the year 2022. Methods: A retrospective cohort was analyzed from the year 2022, with cases being hospitalized by COVID-19 being drawn from SIVEP-GRIPE surveillance. We compared clinical characteristics, comorbidities, and outcomes between CVD carriers and non-carriers, and we also compared vaccinated with two doses vs. those that are unvaccinated in CVD carriers. We performed chi-square, odds ratio, logistic regression, and survival analysis. Results: We included, in the cohort, 112,459 hospital inpatients. An amount of 71,661 (63.72%) of the hospitalized patients had CVD. Regarding deaths, 37,888 (33.69%) died. Regarding vaccination against COVID-19, 20,855 (18.54%) people were not vaccinated with any dose among those with CVD. Death p- < 0.001 (OR 1.307-CI 1.235-1.383) and fever p- < 0.001 (OR 1.156-CI 1.098-1.218) were associated with the unvaccinated CVD carriers, and diarrhea p-0.015 (OR 1.116-CI 1.022-1.218), dyspnea p-0.022 (OR 1.074-CI 1.011-1.142), and respiratory distress p-0.021 (OR 1.070-CI 1.011-1.134) were also recorded. Those patients who possessed predictors of death, including invasive ventilation (p- < 0.001 (OR 8.816-CI 8.313-9.350)), were admitted to the ICU p- < 0.001 (OR 1.754-CI 1.684-1.827), and some had respiratory distress p- < 0.001 (OR 1.367-CI 1.312-1.423), dyspnea p < 0.001 (OR 1.341-CI 1.284-1.400), O2 saturation < 95% p- < 0. 001 (OR 1.307-CI 1.254-1.363), they were unvaccinated against COVID-19 p- < 0.001 (OR 1.258-CI 1.200-1.319), they were of male sex p- < 0.001 (OR 1.179-CI 1.138-1.221), they had diarrhea p-0.018 (OR 1.081-CI 1.013-1.154), and they may have been old p < 0.001 (OR 1.034-CI 1.033-1.035). Survival was shorter for the unvaccinated p-0.003, and p- <0.001. Conclusions: We highlight the predictors of death for those unvaccinated against COVID-19 in this research, and we evidenced the benefits of the COVID-19 vaccine in reducing deaths in hospitalized CVD patients.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Instituto Evandro Chagas (IEC) and Fundação Amazônia de Amparo an Estudos e Pesquisas (FAPESPA). The project was financed by the edict number 013/2021.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Geoprocessamento. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Geoprocessamento. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-Graduação em Biologia Parasitária na Amazônia. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. 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dc.title.pt_BR.fl_str_mv Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
title Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
spellingShingle Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
Sardinha, Daniele Melo
COVID-19
SARS-CoV-2 / patogenicidade
Vacinação / estatística & dados numéricos
Cardiopatias Congênitas
Fatores de Risco de Doenças Cardíacas
Estudos de Coortes
title_short Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
title_full Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
title_fullStr Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
title_full_unstemmed Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
title_sort Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort
author Sardinha, Daniele Melo
author_facet Sardinha, Daniele Melo
Ferreira, Ana Lúcia da Silva
Guimarães, Ricardo José de Paula Souza e
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
author_role author
author2 Ferreira, Ana Lúcia da Silva
Guimarães, Ricardo José de Paula Souza e
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sardinha, Daniele Melo
Ferreira, Ana Lúcia da Silva
Guimarães, Ricardo José de Paula Souza e
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
dc.subject.decsPrimary.pt_BR.fl_str_mv COVID-19
SARS-CoV-2 / patogenicidade
Vacinação / estatística & dados numéricos
Cardiopatias Congênitas
Fatores de Risco de Doenças Cardíacas
Estudos de Coortes
topic COVID-19
SARS-CoV-2 / patogenicidade
Vacinação / estatística & dados numéricos
Cardiopatias Congênitas
Fatores de Risco de Doenças Cardíacas
Estudos de Coortes
description Introduction: COVID-19 in Brazil has already caused, and it still causes, several impacts on health, economy, and education. The risk factors for death involved those with cardiovascular diseases (CVD), which were prioritized for the vaccination of COVID-19. Objective: To investigate the clinical characteristics and outcomes between vaccinated and unvaccinated patients with cardiovascular diseases hospitalized for COVID-19 in Brazil in the year 2022. Methods: A retrospective cohort was analyzed from the year 2022, with cases being hospitalized by COVID-19 being drawn from SIVEP-GRIPE surveillance. We compared clinical characteristics, comorbidities, and outcomes between CVD carriers and non-carriers, and we also compared vaccinated with two doses vs. those that are unvaccinated in CVD carriers. We performed chi-square, odds ratio, logistic regression, and survival analysis. Results: We included, in the cohort, 112,459 hospital inpatients. An amount of 71,661 (63.72%) of the hospitalized patients had CVD. Regarding deaths, 37,888 (33.69%) died. Regarding vaccination against COVID-19, 20,855 (18.54%) people were not vaccinated with any dose among those with CVD. Death p- < 0.001 (OR 1.307-CI 1.235-1.383) and fever p- < 0.001 (OR 1.156-CI 1.098-1.218) were associated with the unvaccinated CVD carriers, and diarrhea p-0.015 (OR 1.116-CI 1.022-1.218), dyspnea p-0.022 (OR 1.074-CI 1.011-1.142), and respiratory distress p-0.021 (OR 1.070-CI 1.011-1.134) were also recorded. Those patients who possessed predictors of death, including invasive ventilation (p- < 0.001 (OR 8.816-CI 8.313-9.350)), were admitted to the ICU p- < 0.001 (OR 1.754-CI 1.684-1.827), and some had respiratory distress p- < 0.001 (OR 1.367-CI 1.312-1.423), dyspnea p < 0.001 (OR 1.341-CI 1.284-1.400), O2 saturation < 95% p- < 0. 001 (OR 1.307-CI 1.254-1.363), they were unvaccinated against COVID-19 p- < 0.001 (OR 1.258-CI 1.200-1.319), they were of male sex p- < 0.001 (OR 1.179-CI 1.138-1.221), they had diarrhea p-0.018 (OR 1.081-CI 1.013-1.154), and they may have been old p < 0.001 (OR 1.034-CI 1.033-1.035). Survival was shorter for the unvaccinated p-0.003, and p- <0.001. Conclusions: We highlight the predictors of death for those unvaccinated against COVID-19 in this research, and we evidenced the benefits of the COVID-19 vaccine in reducing deaths in hospitalized CVD patients.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-08T12:34:26Z
dc.date.available.fl_str_mv 2023-05-08T12:34:26Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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format article
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dc.identifier.citation.fl_str_mv SARDINHA, Daniele Melo et al. Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort. Vaccines, v. 11, n. 4, p. 1-21, Apr. 2023. DOI: https://doi.org/10.3390/vaccines11040861. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146801/pdf/vaccines-11-00861.pdf.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/6815
dc.identifier.issn.-.fl_str_mv 2076-393X
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/vaccines11040861.
identifier_str_mv SARDINHA, Daniele Melo et al. Clinical characteristics and outcomes among vaccinated and unvaccinated patients with cardiovascular disease who were hospitalized for COVID-19 in Brazil: retrospective cohort. Vaccines, v. 11, n. 4, p. 1-21, Apr. 2023. DOI: https://doi.org/10.3390/vaccines11040861. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146801/pdf/vaccines-11-00861.pdf.
2076-393X
10.3390/vaccines11040861.
url https://patua.iec.gov.br/handle/iec/6815
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
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repository.name.fl_str_mv Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)
repository.mail.fl_str_mv clariceneta@iec.gov.br || Biblioteca@iec.gov.br
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