Clinical severity and rotavirus vaccination among children hospitalized for ccute gastroenteritis in Belém, Northern Brazil

• Autor(a) principal: Justino, Maria Cleonice Aguiar
• Data de Publicação: 2016
• Outros Autores: Brasil, Patrícia, Abreu, Erika, Miranda, Yllen, Mascarenhas, Joana D'Arc Pereira, Guerra, Sylvia de Fátima dos Santos, Linhares, Alexandre da Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/3148
• topic: Gastroenterite / prevenção & controle; Gastroenterite / virologia; Infecções por Rotavirus / prevenção & controle; Rotavirus / imunologia; Vacinas contra Rotavirus / uso terapêutico; Índice de Gravidade de Doença; Resultado do Tratamento; Estudos Prospectivos; Ensaio de Imunoadsorção Enzimática / métodos; Doença Aguda

In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (RotarixTM) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n ¼ 252), partially vaccinated (n ¼ 156) and fully vaccinated (n ¼ 615) children. Very severe gastroenteritis (scored 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p ¼ 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p < 0.05). We showed a vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children.