Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2131 |
Resumo: | Norovirus (NoV) is responsible for outbreaks and sporadic cases of nonbacterial acute gastroenteritis in humans worldwide. The virus consists of small round particles containing a single-stranded RNA genome that is divided into three Open Reading Frames. NoV evolves via mechanisms of antigenic drift and recombination, which lead to the emergence of new strains that are capable of causing global epidemics. Recombination usually occurs in the ORF1/ORF2 overlapping region and generates strains with different genotypes in the polymerase and capsid region. The primary objective of this study was to analyze recombination in positive-NoV samples. Specimens were collected during 2011, 2012 and 2014, from children under two years of age presenting gastrointestinal symptoms such as vomiting and diarrhea. The partial polymerase (B region), capsid (D region) genes and the ORF1-ORF2 overlap regions were sequenced in each sample. The recombinant analyses were performed in the Simplot software v.3.5.1 and RDP4 Beta v. 4.6 program. These analyses showed that GII.Pg/GII.1, GII.P7/GII.6, and GII.P22/GII.5 were recombinant strains. To our knowledge, this is the first time that the GII.P22/GII.5 and GII.Pg/GII.1 strains were described in South America and the GII.P7/GII.6 was detected in Northern of Brazil. |
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Hernandez, Juliana das MercesSilva, Luciana Damascena daSousa Junior, Edivaldo CostaLucena, Maria Silvia Souza deSoares, Luana da SilvaMascarenhas, Joana D'Arc PereiraGabbay, Yvone Benchimol2016-06-09T12:04:43Z2016-06-09T12:04:43Z2016HERNANDEZ, Juliana das Merces et al. Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1. Infection, Genetics and Evolution, v. 39, p. 365-371, Apr. 2016. DOI: https://doi.org/10.1016/j.meegid.2016.02.0071567-7257https://patua.iec.gov.br/handle/iec/213110.1016/j.meegid.2016.02.007Norovirus (NoV) is responsible for outbreaks and sporadic cases of nonbacterial acute gastroenteritis in humans worldwide. The virus consists of small round particles containing a single-stranded RNA genome that is divided into three Open Reading Frames. NoV evolves via mechanisms of antigenic drift and recombination, which lead to the emergence of new strains that are capable of causing global epidemics. Recombination usually occurs in the ORF1/ORF2 overlapping region and generates strains with different genotypes in the polymerase and capsid region. The primary objective of this study was to analyze recombination in positive-NoV samples. Specimens were collected during 2011, 2012 and 2014, from children under two years of age presenting gastrointestinal symptoms such as vomiting and diarrhea. The partial polymerase (B region), capsid (D region) genes and the ORF1-ORF2 overlap regions were sequenced in each sample. The recombinant analyses were performed in the Simplot software v.3.5.1 and RDP4 Beta v. 4.6 program. These analyses showed that GII.Pg/GII.1, GII.P7/GII.6, and GII.P22/GII.5 were recombinant strains. To our knowledge, this is the first time that the GII.P22/GII.5 and GII.Pg/GII.1 strains were described in South America and the GII.P7/GII.6 was detected in Northern of Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.application/pdfengElsevier ScienceAnalysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1Análise de recombinantes de norovírus incomuns de Manaus, Amazon região, Brasil: GII. P22 / GII. 5, GII. P7 / GII. 6 e GII. Pg / GII. 1info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20112014Norovirus / genéticaFezes / virologiaFilogeniaReação em Cadeia da Polimerase / métodosManaus (AM)info:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAnalysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1.pdfAnalysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. 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dc.title.pt_BR.fl_str_mv |
Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1 |
dc.title.alternative.pt_BR.fl_str_mv |
Análise de recombinantes de norovírus incomuns de Manaus, Amazon região, Brasil: GII. P22 / GII. 5, GII. P7 / GII. 6 e GII. Pg / GII. 1 |
title |
Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1 |
spellingShingle |
Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1 Hernandez, Juliana das Merces Norovirus / genética Fezes / virologia Filogenia Reação em Cadeia da Polimerase / métodos Manaus (AM) |
title_short |
Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1 |
title_full |
Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1 |
title_fullStr |
Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1 |
title_full_unstemmed |
Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1 |
title_sort |
Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1 |
author |
Hernandez, Juliana das Merces |
author_facet |
Hernandez, Juliana das Merces Silva, Luciana Damascena da Sousa Junior, Edivaldo Costa Lucena, Maria Silvia Souza de Soares, Luana da Silva Mascarenhas, Joana D'Arc Pereira Gabbay, Yvone Benchimol |
author_role |
author |
author2 |
Silva, Luciana Damascena da Sousa Junior, Edivaldo Costa Lucena, Maria Silvia Souza de Soares, Luana da Silva Mascarenhas, Joana D'Arc Pereira Gabbay, Yvone Benchimol |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Hernandez, Juliana das Merces Silva, Luciana Damascena da Sousa Junior, Edivaldo Costa Lucena, Maria Silvia Souza de Soares, Luana da Silva Mascarenhas, Joana D'Arc Pereira Gabbay, Yvone Benchimol |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Norovirus / genética Fezes / virologia Filogenia Reação em Cadeia da Polimerase / métodos Manaus (AM) |
topic |
Norovirus / genética Fezes / virologia Filogenia Reação em Cadeia da Polimerase / métodos Manaus (AM) |
description |
Norovirus (NoV) is responsible for outbreaks and sporadic cases of nonbacterial acute gastroenteritis in humans worldwide. The virus consists of small round particles containing a single-stranded RNA genome that is divided into three Open Reading Frames. NoV evolves via mechanisms of antigenic drift and recombination, which lead to the emergence of new strains that are capable of causing global epidemics. Recombination usually occurs in the ORF1/ORF2 overlapping region and generates strains with different genotypes in the polymerase and capsid region. The primary objective of this study was to analyze recombination in positive-NoV samples. Specimens were collected during 2011, 2012 and 2014, from children under two years of age presenting gastrointestinal symptoms such as vomiting and diarrhea. The partial polymerase (B region), capsid (D region) genes and the ORF1-ORF2 overlap regions were sequenced in each sample. The recombinant analyses were performed in the Simplot software v.3.5.1 and RDP4 Beta v. 4.6 program. These analyses showed that GII.Pg/GII.1, GII.P7/GII.6, and GII.P22/GII.5 were recombinant strains. To our knowledge, this is the first time that the GII.P22/GII.5 and GII.Pg/GII.1 strains were described in South America and the GII.P7/GII.6 was detected in Northern of Brazil. |
publishDate |
2016 |
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2016-06-09T12:04:43Z |
dc.date.available.fl_str_mv |
2016-06-09T12:04:43Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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HERNANDEZ, Juliana das Merces et al. Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1. Infection, Genetics and Evolution, v. 39, p. 365-371, Apr. 2016. DOI: https://doi.org/10.1016/j.meegid.2016.02.007 |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2131 |
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1567-7257 |
dc.identifier.doi.-.fl_str_mv |
10.1016/j.meegid.2016.02.007 |
identifier_str_mv |
HERNANDEZ, Juliana das Merces et al. Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII. P22 / GII. 5, GII. P7 / GII. 6 and GII. Pg / GII. 1. Infection, Genetics and Evolution, v. 39, p. 365-371, Apr. 2016. DOI: https://doi.org/10.1016/j.meegid.2016.02.007 1567-7257 10.1016/j.meegid.2016.02.007 |
url |
https://patua.iec.gov.br/handle/iec/2131 |
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dc.publisher.none.fl_str_mv |
Elsevier Science |
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Elsevier Science |
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