Wide distribution of the variant form of the human malaria parasite Plasmodium vivax
Autor(a) principal: | |
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Data de Publicação: | 1991 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2581 |
Resumo: | We have found polymorphism in the repetitive and nonrepetitive regions of the sporozoite vaccine antigen, the circumsporozoite (CS) protein, in Plasmodium vivax malaria parasites from two geographically distant malaria endemic regions of the world. Like the recently described variant repeat sequence of P. vivax from Thailand, the CS protein repeat sequence of the variant P. vivax parasites from Papua New Guinea and Brazil is ANGA(G/D)(N/D)QPG, which differs from the previously identified CS repeat sequence, GDRA(D/A)GQPA, of P. vivax parasites from South America, Central America, and North Korea. Comparison of the P. vivax CS protein outside the repeat region revealed restricted polymorphism in regions that have exhibited T-cell immune function and sequence heterogeneity in the CS protein of Plasmodium falciparum. Our results show that P. vivax malaria parasites with the variant CS repeat sequences are widespread in nature and that the polymorphism in the CS protein of P. vivax is also present in the nonrepeat region. |
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Qari, Shoukat HGoldman, Ira FPóvoa, Marinete MarinsOliveira, Salma GAlpers, Michael PLal, Altaf A2017-06-05T19:39:06Z2017-06-05T19:39:06Z1991QARI, Shoukat H. et al. Wide distribution of the variant form of the human malaria parasite Plasmodium vivax. Journal of Biological Chemistry, V. 266, N. 25, P. 16297-16300, Sept. 1991.0021-9258https://patua.iec.gov.br/handle/iec/2581We have found polymorphism in the repetitive and nonrepetitive regions of the sporozoite vaccine antigen, the circumsporozoite (CS) protein, in Plasmodium vivax malaria parasites from two geographically distant malaria endemic regions of the world. Like the recently described variant repeat sequence of P. vivax from Thailand, the CS protein repeat sequence of the variant P. vivax parasites from Papua New Guinea and Brazil is ANGA(G/D)(N/D)QPG, which differs from the previously identified CS repeat sequence, GDRA(D/A)GQPA, of P. vivax parasites from South America, Central America, and North Korea. Comparison of the P. vivax CS protein outside the repeat region revealed restricted polymorphism in regions that have exhibited T-cell immune function and sequence heterogeneity in the CS protein of Plasmodium falciparum. Our results show that P. vivax malaria parasites with the variant CS repeat sequences are widespread in nature and that the polymorphism in the CS protein of P. vivax is also present in the nonrepeat region.Center for Infectious Diseases. Centers for Disease Control, Public Health Service. Department of Health and Human Service. Division of Parasitic Diseases. Malaria Branch. Atlanta, GA, USA.Center for Infectious Diseases. Centers for Disease Control, Public Health Service. Department of Health and Human Service. Division of Parasitic Diseases. Malaria Branch. Atlanta, GA, USA.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Papua New Guinea Institute of Medical Research. Madang, PNG.Center for Infectious Diseases. Centers for Disease Control, Public Health Service. Department of Health and Human Service. Division of Parasitic Diseases. Malaria Branch. Atlanta, GA, USA.engAmerican Society for Biochemistry and Molecular BiologyWide distribution of the variant form of the human malaria parasite Plasmodium vivaxinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMaláriaMalária VivaxPlasmodium vivaxMapeamento CromossômicoPlasmodium vivax / genéticaPolimorfismo Genéticoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECTHUMBNAILWide distribution of the variant form of the human malaria parasite Plasmodium vivax.pdf.jpgWide distribution of the variant form of the human malaria parasite Plasmodium vivax.pdf.jpgGenerated Thumbnailimage/jpeg6999https://patua.iec.gov.br/bitstreams/b89e3220-2d75-4210-8dd9-2c97a3a7843f/download1b540379b5c1c03ca0af6a4a0d4871baMD57ORIGINALWide distribution of the variant form of the human malaria parasite Plasmodium vivax.pdfWide distribution of the variant form of the human malaria parasite Plasmodium vivax.pdfapplication/pdf518543https://patua.iec.gov.br/bitstreams/9a7d4bcc-f6be-4ef1-9cd4-efbb718cccd9/downloade877fc0ad0d011099d6a7415174d6f6aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/ce2827ba-b874-439c-8fcd-fe05c2f1a386/download52f1732ea66fbd1123abe39f5373b797MD52TEXTJ. Biol. Chem.-1991-Qari-16297-300.pdf.txtJ. Biol. Chem.-1991-Qari-16297-300.pdf.txtExtracted texttext/plain33395https://patua.iec.gov.br/bitstreams/d9ed3e7f-ae6a-411f-aca9-bfdc05719939/downloadf2b59c01bb9cfc38fa9a15d1d25e017bMD53Wide distribution of the variant form of the human malaria parasite Plasmodium vivax.pdf.txtWide distribution of the variant form of the human malaria parasite Plasmodium vivax.pdf.txtExtracted texttext/plain33618https://patua.iec.gov.br/bitstreams/350f14f5-a578-4b50-9694-937b6cb329b0/download2d19facaf18f2919f2113602e06e856cMD56iec/25812022-10-20 23:12:18.076oai:patua.iec.gov.br:iec/2581https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T23:12:18Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Wide distribution of the variant form of the human malaria parasite Plasmodium vivax |
title |
Wide distribution of the variant form of the human malaria parasite Plasmodium vivax |
spellingShingle |
Wide distribution of the variant form of the human malaria parasite Plasmodium vivax Qari, Shoukat H Malária Malária Vivax Plasmodium vivax Mapeamento Cromossômico Plasmodium vivax / genética Polimorfismo Genético |
title_short |
Wide distribution of the variant form of the human malaria parasite Plasmodium vivax |
title_full |
Wide distribution of the variant form of the human malaria parasite Plasmodium vivax |
title_fullStr |
Wide distribution of the variant form of the human malaria parasite Plasmodium vivax |
title_full_unstemmed |
Wide distribution of the variant form of the human malaria parasite Plasmodium vivax |
title_sort |
Wide distribution of the variant form of the human malaria parasite Plasmodium vivax |
author |
Qari, Shoukat H |
author_facet |
Qari, Shoukat H Goldman, Ira F Póvoa, Marinete Marins Oliveira, Salma G Alpers, Michael P Lal, Altaf A |
author_role |
author |
author2 |
Goldman, Ira F Póvoa, Marinete Marins Oliveira, Salma G Alpers, Michael P Lal, Altaf A |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Qari, Shoukat H Goldman, Ira F Póvoa, Marinete Marins Oliveira, Salma G Alpers, Michael P Lal, Altaf A |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Malária Malária Vivax Plasmodium vivax Mapeamento Cromossômico Plasmodium vivax / genética Polimorfismo Genético |
topic |
Malária Malária Vivax Plasmodium vivax Mapeamento Cromossômico Plasmodium vivax / genética Polimorfismo Genético |
description |
We have found polymorphism in the repetitive and nonrepetitive regions of the sporozoite vaccine antigen, the circumsporozoite (CS) protein, in Plasmodium vivax malaria parasites from two geographically distant malaria endemic regions of the world. Like the recently described variant repeat sequence of P. vivax from Thailand, the CS protein repeat sequence of the variant P. vivax parasites from Papua New Guinea and Brazil is ANGA(G/D)(N/D)QPG, which differs from the previously identified CS repeat sequence, GDRA(D/A)GQPA, of P. vivax parasites from South America, Central America, and North Korea. Comparison of the P. vivax CS protein outside the repeat region revealed restricted polymorphism in regions that have exhibited T-cell immune function and sequence heterogeneity in the CS protein of Plasmodium falciparum. Our results show that P. vivax malaria parasites with the variant CS repeat sequences are widespread in nature and that the polymorphism in the CS protein of P. vivax is also present in the nonrepeat region. |
publishDate |
1991 |
dc.date.issued.fl_str_mv |
1991 |
dc.date.accessioned.fl_str_mv |
2017-06-05T19:39:06Z |
dc.date.available.fl_str_mv |
2017-06-05T19:39:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
QARI, Shoukat H. et al. Wide distribution of the variant form of the human malaria parasite Plasmodium vivax. Journal of Biological Chemistry, V. 266, N. 25, P. 16297-16300, Sept. 1991. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2581 |
dc.identifier.issn.-.fl_str_mv |
0021-9258 |
identifier_str_mv |
QARI, Shoukat H. et al. Wide distribution of the variant form of the human malaria parasite Plasmodium vivax. Journal of Biological Chemistry, V. 266, N. 25, P. 16297-16300, Sept. 1991. 0021-9258 |
url |
https://patua.iec.gov.br/handle/iec/2581 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Society for Biochemistry and Molecular Biology |
publisher.none.fl_str_mv |
American Society for Biochemistry and Molecular Biology |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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