Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/6936 |
Resumo: | The present study was designed as an exploratory investigation to characterize the overall profile of chemokines, growth factors, and pro-inflammatory/regulatory cytokines during acute DENV infection according to DENV-1, DENV-2, DENV-4 serotypes and age: children: <1–10-year-old (yo); adolescents:11–20 yo; adults 21–40 yo; and older adults: 41–75 yo. The levels of soluble immunemediators were measured in serum by high-throughput microbeads array in 636 subjects including 317 DENV-infected and 319 age-matching non-infected control (NI). Overall, most soluble mediators were increased in DENV-infected patients as compared to NI group regardless of age and DENV serotype, with high magnitude order of increase for CCL2, CXCL10, IL-1β, IFN-γ, IL1-Ra (fold change >3x), except PDGF in which no fold change was observed. Moreover, despite the age ranges, DENV-1 and DENV-4 presented increased levels of VEGF, IL-6, and TNF-α in serum but decreased levels of PDGF, while DENV-2 exhibited increased levels of CXCL8, CCL4, and IL-12. Noteworthy was that DENV-2 showed increased levels of IL-12, IL-15, IL-17, IL-4, IL-9, and IL-13, and maintained an unaltered levels of PDGF at younger ages (<1–10 yo and 11–20 yo), whereas in older ages (21–40 yo and 41–75 yo), the results showed increased levels of CCL2, IL-6, and TNF-α, but lower levels of PDGF. In general, DENV infection at younger age groups exhibited more complex network immunoclusters as compared to older age groups. Multivariate analysis revealed a clustering of DENV cases according to age for a set of soluble mediators especially in subjects infected with DENV-2 serotype. Altogether, our findings demonstrate that the profile of circulating soluble mediators differs substantially in acute DENV according to age and DENV serotypes suggesting the participation of serotype-associated immune response, which may represent a potential target for development of therapeutics and could be used to assist medical directive for precise clinical management of severe cases. |
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Sucupira, Pedro Henrique FerreiraFerreira, Milene SilveiraSilva, Mikelly Santos Coutinho daBicalho, Kelly AlvesAzevedo, Ana Carolina CampiSousa, Joaquim Pedro Brito deMagalhães, Vanessa PeruhypeRios, MariaKonduru, KrishnamurthyCarvalho, Andréa TeixeiraReis, Jordana Grazziela Alves Coelho dosAntonelli, Lis Ribeiro do ValleRezende, Vitor Bortolo deMelo, Fernanda Ludolf Ribeiro deGarcia, Cristiana CoutoAndrade, Jesuanne Carla SilvaRocha, Ismael Artur da CostaRocha, Lucia Alves daSilva, Valderjane AprigioPinto, Sérgio DamascenoMelo, Sabrina Araújo deCosta, Allyson GuimarãesGomes, Matheus de SouzaAmaral, Laurence RodriguesBertarini, Pedro Luiz LimaFurtado, Erilene Cristina da SilvaSilva, Eliana Vieira Pinto daRamos, Bruna AlvesSantos, Éder Barros dosFreitas, Maria de Nazaré OliveiraFaria, Ana Maria CaetanoVasconcelos, Pedro Fernando da CostaBastos, Michele de SouzaMartins, Livia CarícioMartins Filho, Olindo AssisAraújo, Márcio Sobreira Silva2023-09-11T16:56:53Z2023-09-11T16:56:53Z2023SUCUPIRA, Pedro Henrique Ferreira et al. Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection. Cytokine, v. 169, n. 156306, Sept. 2023. DOI: https://doi.org/10.1016/j.cyto.2023.156306.1043-4666https://patua.iec.gov.br/handle/iec/693610.1016/j.cyto.2023.156306The present study was designed as an exploratory investigation to characterize the overall profile of chemokines, growth factors, and pro-inflammatory/regulatory cytokines during acute DENV infection according to DENV-1, DENV-2, DENV-4 serotypes and age: children: <1–10-year-old (yo); adolescents:11–20 yo; adults 21–40 yo; and older adults: 41–75 yo. The levels of soluble immunemediators were measured in serum by high-throughput microbeads array in 636 subjects including 317 DENV-infected and 319 age-matching non-infected control (NI). Overall, most soluble mediators were increased in DENV-infected patients as compared to NI group regardless of age and DENV serotype, with high magnitude order of increase for CCL2, CXCL10, IL-1β, IFN-γ, IL1-Ra (fold change >3x), except PDGF in which no fold change was observed. Moreover, despite the age ranges, DENV-1 and DENV-4 presented increased levels of VEGF, IL-6, and TNF-α in serum but decreased levels of PDGF, while DENV-2 exhibited increased levels of CXCL8, CCL4, and IL-12. Noteworthy was that DENV-2 showed increased levels of IL-12, IL-15, IL-17, IL-4, IL-9, and IL-13, and maintained an unaltered levels of PDGF at younger ages (<1–10 yo and 11–20 yo), whereas in older ages (21–40 yo and 41–75 yo), the results showed increased levels of CCL2, IL-6, and TNF-α, but lower levels of PDGF. In general, DENV infection at younger age groups exhibited more complex network immunoclusters as compared to older age groups. Multivariate analysis revealed a clustering of DENV cases according to age for a set of soluble mediators especially in subjects infected with DENV-2 serotype. Altogether, our findings demonstrate that the profile of circulating soluble mediators differs substantially in acute DENV according to age and DENV serotypes suggesting the participation of serotype-associated immune response, which may represent a potential target for development of therapeutics and could be used to assist medical directive for precise clinical management of severe cases.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.U.S. Food and Drug Administration. Center for Biologics Evaluation and Research. Office of Blood Research and Review. Silver Spring, MD, USA.U.S. Food and Drug Administration. Center for Biologics Evaluation and Research. Office of Blood Research and Review. Silver Spring, MD, USA.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e Sarampo. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil / Universidade Federal do Amazonas. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil.Universidade Federal do Amazonas. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil / Universidade Federal do Amazonas. Manaus, AM, Brazil / Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil.Universidade Federal de Uberlândia. Rede Multidisciplinar de Pesquisa, Ciência e Tecnologia. Laboratório de Bioinformática e Análises Moleculares. Campus Patos de Minas, MG, Brazil / Universidade Federal de Uberlândia. Faculdade de Engenharia Elétrica. Laboratório de Tecnologias Urbanas e Rurais. Campus Patos de Minas, MG, Brazil.Universidade Federal de Uberlândia. Rede Multidisciplinar de Pesquisa, Ciência e Tecnologia. Laboratório de Bioinformática e Análises Moleculares. Campus Patos de Minas, MG, Brazil / Universidade Federal de Uberlândia. Faculdade de Engenharia Elétrica. Laboratório de Tecnologias Urbanas e Rurais. Campus Patos de Minas, MG, Brazil.Universidade Federal de Uberlândia. Rede Multidisciplinar de Pesquisa, Ciência e Tecnologia. Laboratório de Bioinformática e Análises Moleculares. Campus Patos de Minas, MG, Brazil / Universidade Federal de Uberlândia. Faculdade de Engenharia Elétrica. Laboratório de Tecnologias Urbanas e Rurais. Campus Patos de Minas, MG, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Centro de Ciências Biológicas e da Saúde. Departamento de Patologia. Belém, PA, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil / Universidade Federal do Amazonas. Manaus, AM, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. 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dc.title.pt_BR.fl_str_mv |
Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection |
title |
Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection |
spellingShingle |
Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection Sucupira, Pedro Henrique Ferreira Dengue Vírus da Dengue / patogenicidade Mediadores da Inflamação Citocinas Quimiocinas |
title_short |
Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection |
title_full |
Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection |
title_fullStr |
Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection |
title_full_unstemmed |
Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection |
title_sort |
Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection |
author |
Sucupira, Pedro Henrique Ferreira |
author_facet |
Sucupira, Pedro Henrique Ferreira Ferreira, Milene Silveira Silva, Mikelly Santos Coutinho da Bicalho, Kelly Alves Azevedo, Ana Carolina Campi Sousa, Joaquim Pedro Brito de Magalhães, Vanessa Peruhype Rios, Maria Konduru, Krishnamurthy Carvalho, Andréa Teixeira Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Rezende, Vitor Bortolo de Melo, Fernanda Ludolf Ribeiro de Garcia, Cristiana Couto Andrade, Jesuanne Carla Silva Rocha, Ismael Artur da Costa Rocha, Lucia Alves da Silva, Valderjane Aprigio Pinto, Sérgio Damasceno Melo, Sabrina Araújo de Costa, Allyson Guimarães Gomes, Matheus de Souza Amaral, Laurence Rodrigues Bertarini, Pedro Luiz Lima Furtado, Erilene Cristina da Silva Silva, Eliana Vieira Pinto da Ramos, Bruna Alves Santos, Éder Barros dos Freitas, Maria de Nazaré Oliveira Faria, Ana Maria Caetano Vasconcelos, Pedro Fernando da Costa Bastos, Michele de Souza Martins, Livia Carício Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva |
author_role |
author |
author2 |
Ferreira, Milene Silveira Silva, Mikelly Santos Coutinho da Bicalho, Kelly Alves Azevedo, Ana Carolina Campi Sousa, Joaquim Pedro Brito de Magalhães, Vanessa Peruhype Rios, Maria Konduru, Krishnamurthy Carvalho, Andréa Teixeira Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Rezende, Vitor Bortolo de Melo, Fernanda Ludolf Ribeiro de Garcia, Cristiana Couto Andrade, Jesuanne Carla Silva Rocha, Ismael Artur da Costa Rocha, Lucia Alves da Silva, Valderjane Aprigio Pinto, Sérgio Damasceno Melo, Sabrina Araújo de Costa, Allyson Guimarães Gomes, Matheus de Souza Amaral, Laurence Rodrigues Bertarini, Pedro Luiz Lima Furtado, Erilene Cristina da Silva Silva, Eliana Vieira Pinto da Ramos, Bruna Alves Santos, Éder Barros dos Freitas, Maria de Nazaré Oliveira Faria, Ana Maria Caetano Vasconcelos, Pedro Fernando da Costa Bastos, Michele de Souza Martins, Livia Carício Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sucupira, Pedro Henrique Ferreira Ferreira, Milene Silveira Silva, Mikelly Santos Coutinho da Bicalho, Kelly Alves Azevedo, Ana Carolina Campi Sousa, Joaquim Pedro Brito de Magalhães, Vanessa Peruhype Rios, Maria Konduru, Krishnamurthy Carvalho, Andréa Teixeira Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Rezende, Vitor Bortolo de Melo, Fernanda Ludolf Ribeiro de Garcia, Cristiana Couto Andrade, Jesuanne Carla Silva Rocha, Ismael Artur da Costa Rocha, Lucia Alves da Silva, Valderjane Aprigio Pinto, Sérgio Damasceno Melo, Sabrina Araújo de Costa, Allyson Guimarães Gomes, Matheus de Souza Amaral, Laurence Rodrigues Bertarini, Pedro Luiz Lima Furtado, Erilene Cristina da Silva Silva, Eliana Vieira Pinto da Ramos, Bruna Alves Santos, Éder Barros dos Freitas, Maria de Nazaré Oliveira Faria, Ana Maria Caetano Vasconcelos, Pedro Fernando da Costa Bastos, Michele de Souza Martins, Livia Carício Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Dengue Vírus da Dengue / patogenicidade Mediadores da Inflamação Citocinas Quimiocinas |
topic |
Dengue Vírus da Dengue / patogenicidade Mediadores da Inflamação Citocinas Quimiocinas |
description |
The present study was designed as an exploratory investigation to characterize the overall profile of chemokines, growth factors, and pro-inflammatory/regulatory cytokines during acute DENV infection according to DENV-1, DENV-2, DENV-4 serotypes and age: children: <1–10-year-old (yo); adolescents:11–20 yo; adults 21–40 yo; and older adults: 41–75 yo. The levels of soluble immunemediators were measured in serum by high-throughput microbeads array in 636 subjects including 317 DENV-infected and 319 age-matching non-infected control (NI). Overall, most soluble mediators were increased in DENV-infected patients as compared to NI group regardless of age and DENV serotype, with high magnitude order of increase for CCL2, CXCL10, IL-1β, IFN-γ, IL1-Ra (fold change >3x), except PDGF in which no fold change was observed. Moreover, despite the age ranges, DENV-1 and DENV-4 presented increased levels of VEGF, IL-6, and TNF-α in serum but decreased levels of PDGF, while DENV-2 exhibited increased levels of CXCL8, CCL4, and IL-12. Noteworthy was that DENV-2 showed increased levels of IL-12, IL-15, IL-17, IL-4, IL-9, and IL-13, and maintained an unaltered levels of PDGF at younger ages (<1–10 yo and 11–20 yo), whereas in older ages (21–40 yo and 41–75 yo), the results showed increased levels of CCL2, IL-6, and TNF-α, but lower levels of PDGF. In general, DENV infection at younger age groups exhibited more complex network immunoclusters as compared to older age groups. Multivariate analysis revealed a clustering of DENV cases according to age for a set of soluble mediators especially in subjects infected with DENV-2 serotype. Altogether, our findings demonstrate that the profile of circulating soluble mediators differs substantially in acute DENV according to age and DENV serotypes suggesting the participation of serotype-associated immune response, which may represent a potential target for development of therapeutics and could be used to assist medical directive for precise clinical management of severe cases. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-09-11T16:56:53Z |
dc.date.available.fl_str_mv |
2023-09-11T16:56:53Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SUCUPIRA, Pedro Henrique Ferreira et al. Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection. Cytokine, v. 169, n. 156306, Sept. 2023. DOI: https://doi.org/10.1016/j.cyto.2023.156306. |
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https://patua.iec.gov.br/handle/iec/6936 |
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1043-4666 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.cyto.2023.156306 |
identifier_str_mv |
SUCUPIRA, Pedro Henrique Ferreira et al. Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection. Cytokine, v. 169, n. 156306, Sept. 2023. DOI: https://doi.org/10.1016/j.cyto.2023.156306. 1043-4666 10.1016/j.cyto.2023.156306 |
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https://patua.iec.gov.br/handle/iec/6936 |
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Elsevier |
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Elsevier |
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