A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region

Detalhes bibliográficos
Autor(a) principal: Silveira, Fernando Tobias
Data de Publicação: 2010
Outros Autores: Lainson, Ralph, Crescente, José Angelo Barletta, Souza, Adelson Alcimar Almeida de, Campos, Marliane Batista, Gomes, Claudia Maria de Castro, Laureti, Márcia. D, Corbett, Carlos Eduardo Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/687
Resumo: This prospective study was carried out from October 2003 to December 2005 and involved a cohort of 946 individuals of both genders, aged 1-89 years, from an endemic area for American visceral leishmaniasis (AVL), in Pará State, Brazil. The aim of the study was to analyze the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection represented by the following clinical-immunological profiles: asymptomatic infection (AI); symptomatic infection (SI=AVL); subclinical oligosymptomatic infection (SOI); subclinical resistant infection (SRI); and indeterminate initial infection (III). Infection diagnosis was determined by the indirect fluorescent antibody test and leishmanin skin test. In total, 231 cases of infection were diagnosed: the AI profile was the most frequent (73.2 percent), followed by SRI (12.1 percent), III (9.9 percent), SI (2.6 percent) and SOI (2.2 percent). The major conclusion regarding evolution dynamics was that the III profile plays a pivotal role from which the cases evolve to either the resistant, SRI and AI, or susceptible, SOI and SI, profiles; only one of the 23 III cases evolved to SI, while most evolved to either SRI (nine cases) or SOI (five cases) and eight cases remained as III.
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spelling Silveira, Fernando TobiasLainson, RalphCrescente, José Angelo BarlettaSouza, Adelson Alcimar Almeida deCampos, Marliane BatistaGomes, Claudia Maria de CastroLaureti, Márcia. DCorbett, Carlos Eduardo Pereira2016-01-26T11:36:41Z2016-01-26T11:36:41Z2010SILVEIRA, Fernando Tobias et al. A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 104, n. 8, p. 529-535, 2010.0035-9203https://patua.iec.gov.br/handle/iec/68710.1016/j.trstmh.2010.05.002This prospective study was carried out from October 2003 to December 2005 and involved a cohort of 946 individuals of both genders, aged 1-89 years, from an endemic area for American visceral leishmaniasis (AVL), in Pará State, Brazil. The aim of the study was to analyze the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection represented by the following clinical-immunological profiles: asymptomatic infection (AI); symptomatic infection (SI=AVL); subclinical oligosymptomatic infection (SOI); subclinical resistant infection (SRI); and indeterminate initial infection (III). Infection diagnosis was determined by the indirect fluorescent antibody test and leishmanin skin test. In total, 231 cases of infection were diagnosed: the AI profile was the most frequent (73.2 percent), followed by SRI (12.1 percent), III (9.9 percent), SI (2.6 percent) and SOI (2.2 percent). The major conclusion regarding evolution dynamics was that the III profile plays a pivotal role from which the cases evolve to either the resistant, SRI and AI, or susceptible, SOI and SI, profiles; only one of the 23 III cases evolved to SI, while most evolved to either SRI (nine cases) or SOI (five cases) and eight cases remained as III.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Pará Federal University. Tropical Medicine Institute. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Pará Federal University. Tropical Medicine Institute. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Medical School of São Paulo University. Pathology Departament. São Paulo, SP, Brazil.Medical School of São Paulo University. Pathology Departament. São Paulo, SP, Brazil.Medical School of São Paulo University. Pathology Departament. 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dc.title.pt_BR.fl_str_mv A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
title A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
spellingShingle A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
Silveira, Fernando Tobias
Leishmania infantum / parasitologia
Leishmania infantum / imunologia
Estudos Longitudinais
Testes Imunológicos
title_short A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
title_full A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
title_fullStr A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
title_full_unstemmed A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
title_sort A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
author Silveira, Fernando Tobias
author_facet Silveira, Fernando Tobias
Lainson, Ralph
Crescente, José Angelo Barletta
Souza, Adelson Alcimar Almeida de
Campos, Marliane Batista
Gomes, Claudia Maria de Castro
Laureti, Márcia. D
Corbett, Carlos Eduardo Pereira
author_role author
author2 Lainson, Ralph
Crescente, José Angelo Barletta
Souza, Adelson Alcimar Almeida de
Campos, Marliane Batista
Gomes, Claudia Maria de Castro
Laureti, Márcia. D
Corbett, Carlos Eduardo Pereira
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silveira, Fernando Tobias
Lainson, Ralph
Crescente, José Angelo Barletta
Souza, Adelson Alcimar Almeida de
Campos, Marliane Batista
Gomes, Claudia Maria de Castro
Laureti, Márcia. D
Corbett, Carlos Eduardo Pereira
dc.subject.decsPrimary.pt_BR.fl_str_mv Leishmania infantum / parasitologia
Leishmania infantum / imunologia
Estudos Longitudinais
Testes Imunológicos
topic Leishmania infantum / parasitologia
Leishmania infantum / imunologia
Estudos Longitudinais
Testes Imunológicos
description This prospective study was carried out from October 2003 to December 2005 and involved a cohort of 946 individuals of both genders, aged 1-89 years, from an endemic area for American visceral leishmaniasis (AVL), in Pará State, Brazil. The aim of the study was to analyze the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection represented by the following clinical-immunological profiles: asymptomatic infection (AI); symptomatic infection (SI=AVL); subclinical oligosymptomatic infection (SOI); subclinical resistant infection (SRI); and indeterminate initial infection (III). Infection diagnosis was determined by the indirect fluorescent antibody test and leishmanin skin test. In total, 231 cases of infection were diagnosed: the AI profile was the most frequent (73.2 percent), followed by SRI (12.1 percent), III (9.9 percent), SI (2.6 percent) and SOI (2.2 percent). The major conclusion regarding evolution dynamics was that the III profile plays a pivotal role from which the cases evolve to either the resistant, SRI and AI, or susceptible, SOI and SI, profiles; only one of the 23 III cases evolved to SI, while most evolved to either SRI (nine cases) or SOI (five cases) and eight cases remained as III.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2016-01-26T11:36:41Z
dc.date.available.fl_str_mv 2016-01-26T11:36:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SILVEIRA, Fernando Tobias et al. A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 104, n. 8, p. 529-535, 2010.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/687
dc.identifier.issn.-.fl_str_mv 0035-9203
dc.identifier.doi.-.fl_str_mv 10.1016/j.trstmh.2010.05.002
identifier_str_mv SILVEIRA, Fernando Tobias et al. A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 104, n. 8, p. 529-535, 2010.
0035-9203
10.1016/j.trstmh.2010.05.002
url https://patua.iec.gov.br/handle/iec/687
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dc.coverage.temporalragefrom.-.fl_str_mv 2003
dc.coverage.temporalrageupto.-.fl_str_mv 2005
dc.publisher.none.fl_str_mv Oxford University Press
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