A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/687 |
Resumo: | This prospective study was carried out from October 2003 to December 2005 and involved a cohort of 946 individuals of both genders, aged 1-89 years, from an endemic area for American visceral leishmaniasis (AVL), in Pará State, Brazil. The aim of the study was to analyze the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection represented by the following clinical-immunological profiles: asymptomatic infection (AI); symptomatic infection (SI=AVL); subclinical oligosymptomatic infection (SOI); subclinical resistant infection (SRI); and indeterminate initial infection (III). Infection diagnosis was determined by the indirect fluorescent antibody test and leishmanin skin test. In total, 231 cases of infection were diagnosed: the AI profile was the most frequent (73.2 percent), followed by SRI (12.1 percent), III (9.9 percent), SI (2.6 percent) and SOI (2.2 percent). The major conclusion regarding evolution dynamics was that the III profile plays a pivotal role from which the cases evolve to either the resistant, SRI and AI, or susceptible, SOI and SI, profiles; only one of the 23 III cases evolved to SI, while most evolved to either SRI (nine cases) or SOI (five cases) and eight cases remained as III. |
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Silveira, Fernando TobiasLainson, RalphCrescente, José Angelo BarlettaSouza, Adelson Alcimar Almeida deCampos, Marliane BatistaGomes, Claudia Maria de CastroLaureti, Márcia. DCorbett, Carlos Eduardo Pereira2016-01-26T11:36:41Z2016-01-26T11:36:41Z2010SILVEIRA, Fernando Tobias et al. A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 104, n. 8, p. 529-535, 2010.0035-9203https://patua.iec.gov.br/handle/iec/68710.1016/j.trstmh.2010.05.002This prospective study was carried out from October 2003 to December 2005 and involved a cohort of 946 individuals of both genders, aged 1-89 years, from an endemic area for American visceral leishmaniasis (AVL), in Pará State, Brazil. The aim of the study was to analyze the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection represented by the following clinical-immunological profiles: asymptomatic infection (AI); symptomatic infection (SI=AVL); subclinical oligosymptomatic infection (SOI); subclinical resistant infection (SRI); and indeterminate initial infection (III). Infection diagnosis was determined by the indirect fluorescent antibody test and leishmanin skin test. In total, 231 cases of infection were diagnosed: the AI profile was the most frequent (73.2 percent), followed by SRI (12.1 percent), III (9.9 percent), SI (2.6 percent) and SOI (2.2 percent). The major conclusion regarding evolution dynamics was that the III profile plays a pivotal role from which the cases evolve to either the resistant, SRI and AI, or susceptible, SOI and SI, profiles; only one of the 23 III cases evolved to SI, while most evolved to either SRI (nine cases) or SOI (five cases) and eight cases remained as III.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Pará Federal University. Tropical Medicine Institute. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Pará Federal University. Tropical Medicine Institute. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Medical School of São Paulo University. Pathology Departament. São Paulo, SP, Brazil.Medical School of São Paulo University. Pathology Departament. São Paulo, SP, Brazil.Medical School of São Paulo University. Pathology Departament. 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dc.title.pt_BR.fl_str_mv |
A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region |
title |
A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region |
spellingShingle |
A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region Silveira, Fernando Tobias Leishmania infantum / parasitologia Leishmania infantum / imunologia Estudos Longitudinais Testes Imunológicos |
title_short |
A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region |
title_full |
A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region |
title_fullStr |
A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region |
title_full_unstemmed |
A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region |
title_sort |
A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region |
author |
Silveira, Fernando Tobias |
author_facet |
Silveira, Fernando Tobias Lainson, Ralph Crescente, José Angelo Barletta Souza, Adelson Alcimar Almeida de Campos, Marliane Batista Gomes, Claudia Maria de Castro Laureti, Márcia. D Corbett, Carlos Eduardo Pereira |
author_role |
author |
author2 |
Lainson, Ralph Crescente, José Angelo Barletta Souza, Adelson Alcimar Almeida de Campos, Marliane Batista Gomes, Claudia Maria de Castro Laureti, Márcia. D Corbett, Carlos Eduardo Pereira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silveira, Fernando Tobias Lainson, Ralph Crescente, José Angelo Barletta Souza, Adelson Alcimar Almeida de Campos, Marliane Batista Gomes, Claudia Maria de Castro Laureti, Márcia. D Corbett, Carlos Eduardo Pereira |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Leishmania infantum / parasitologia Leishmania infantum / imunologia Estudos Longitudinais Testes Imunológicos |
topic |
Leishmania infantum / parasitologia Leishmania infantum / imunologia Estudos Longitudinais Testes Imunológicos |
description |
This prospective study was carried out from October 2003 to December 2005 and involved a cohort of 946 individuals of both genders, aged 1-89 years, from an endemic area for American visceral leishmaniasis (AVL), in Pará State, Brazil. The aim of the study was to analyze the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection represented by the following clinical-immunological profiles: asymptomatic infection (AI); symptomatic infection (SI=AVL); subclinical oligosymptomatic infection (SOI); subclinical resistant infection (SRI); and indeterminate initial infection (III). Infection diagnosis was determined by the indirect fluorescent antibody test and leishmanin skin test. In total, 231 cases of infection were diagnosed: the AI profile was the most frequent (73.2 percent), followed by SRI (12.1 percent), III (9.9 percent), SI (2.6 percent) and SOI (2.2 percent). The major conclusion regarding evolution dynamics was that the III profile plays a pivotal role from which the cases evolve to either the resistant, SRI and AI, or susceptible, SOI and SI, profiles; only one of the 23 III cases evolved to SI, while most evolved to either SRI (nine cases) or SOI (five cases) and eight cases remained as III. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2016-01-26T11:36:41Z |
dc.date.available.fl_str_mv |
2016-01-26T11:36:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVEIRA, Fernando Tobias et al. A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 104, n. 8, p. 529-535, 2010. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/687 |
dc.identifier.issn.-.fl_str_mv |
0035-9203 |
dc.identifier.doi.-.fl_str_mv |
10.1016/j.trstmh.2010.05.002 |
identifier_str_mv |
SILVEIRA, Fernando Tobias et al. A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L. ) infantum chagasi infection in the Brazilian Amazon region. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 104, n. 8, p. 529-535, 2010. 0035-9203 10.1016/j.trstmh.2010.05.002 |
url |
https://patua.iec.gov.br/handle/iec/687 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.coverage.temporalragefrom.-.fl_str_mv |
2003 |
dc.coverage.temporalrageupto.-.fl_str_mv |
2005 |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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