Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/1040 |
Resumo: | The elimination of seropositive dogs in Brazil has been used to control zoonotic visceral leishmaniasis but with little success. To elucidate the reasons for this, the infectiousness of 50 sentinel dogs exposed to natural Leishmania chagasi infection was assessed through time by xenodiagnosis with the sandfly vector, Lutzomyia longipalpis. Eighteen (43%) of 42 infected dogs became infectious after a median of 333 days in the field (105 days after seroconversion). Seven highly infectious dogs (17%) accounted for 180% of sandfly infections. There were positive correlations between infectiousness and anti-Leishmania immunoglobulin G, parasite detection by polymerase chain reaction, and clinical disease (logistic regression, –0.18). The sen- 2 r p 0.08 sitivity of enzyme-linked immunosorbent assay to detect currently infectious dogs was high (96%) but lower in the latent period (!63%), and specificity was low (24%). Mathematical modeling suggests that culling programs fail because of high incidence of infection and infectiousness, the insensitivity of the diagnostic test to detect infectious dogs, and time delays between diagnosis and culling. |
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Courtenay, OrinQuinnell, Rupert JSantos, Lourdes Maria Garcez dosShaw, Jeffrey JonDye, Christopher2016-01-26T11:43:19Z2016-01-26T11:43:19Z2002COURTENAY, Orin et al. Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. The Journal of Infectious Diseases, v. 189, n. 9, p. 1314-1320, 20020022-1899https://patua.iec.gov.br/handle/iec/1040The elimination of seropositive dogs in Brazil has been used to control zoonotic visceral leishmaniasis but with little success. To elucidate the reasons for this, the infectiousness of 50 sentinel dogs exposed to natural Leishmania chagasi infection was assessed through time by xenodiagnosis with the sandfly vector, Lutzomyia longipalpis. Eighteen (43%) of 42 infected dogs became infectious after a median of 333 days in the field (105 days after seroconversion). Seven highly infectious dogs (17%) accounted for 180% of sandfly infections. There were positive correlations between infectiousness and anti-Leishmania immunoglobulin G, parasite detection by polymerase chain reaction, and clinical disease (logistic regression, –0.18). The sen- 2 r p 0.08 sitivity of enzyme-linked immunosorbent assay to detect currently infectious dogs was high (96%) but lower in the latent period (!63%), and specificity was low (24%). Mathematical modeling suggests that culling programs fail because of high incidence of infection and infectiousness, the insensitivity of the diagnostic test to detect infectious dogs, and time delays between diagnosis and culling.University of Warwick. Department of Biological Sciences. Ecology and Epidemiology Group. Coventry, UK / London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. London.University of Leeds. School of Biology. Leeds, UK / London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. London.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. 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dc.title.pt_BR.fl_str_mv |
Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission |
title |
Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission |
spellingShingle |
Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission Courtenay, Orin Leishmaniose Visceral / prevenção & controle Leishmania infantum / patogenicidade Xenodiagnóstico / métodos Insetos Vetores Cães |
title_short |
Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission |
title_full |
Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission |
title_fullStr |
Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission |
title_full_unstemmed |
Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission |
title_sort |
Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission |
author |
Courtenay, Orin |
author_facet |
Courtenay, Orin Quinnell, Rupert J Santos, Lourdes Maria Garcez dos Shaw, Jeffrey Jon Dye, Christopher |
author_role |
author |
author2 |
Quinnell, Rupert J Santos, Lourdes Maria Garcez dos Shaw, Jeffrey Jon Dye, Christopher |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Courtenay, Orin Quinnell, Rupert J Santos, Lourdes Maria Garcez dos Shaw, Jeffrey Jon Dye, Christopher |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Leishmaniose Visceral / prevenção & controle Leishmania infantum / patogenicidade Xenodiagnóstico / métodos Insetos Vetores Cães |
topic |
Leishmaniose Visceral / prevenção & controle Leishmania infantum / patogenicidade Xenodiagnóstico / métodos Insetos Vetores Cães |
description |
The elimination of seropositive dogs in Brazil has been used to control zoonotic visceral leishmaniasis but with little success. To elucidate the reasons for this, the infectiousness of 50 sentinel dogs exposed to natural Leishmania chagasi infection was assessed through time by xenodiagnosis with the sandfly vector, Lutzomyia longipalpis. Eighteen (43%) of 42 infected dogs became infectious after a median of 333 days in the field (105 days after seroconversion). Seven highly infectious dogs (17%) accounted for 180% of sandfly infections. There were positive correlations between infectiousness and anti-Leishmania immunoglobulin G, parasite detection by polymerase chain reaction, and clinical disease (logistic regression, –0.18). The sen- 2 r p 0.08 sitivity of enzyme-linked immunosorbent assay to detect currently infectious dogs was high (96%) but lower in the latent period (!63%), and specificity was low (24%). Mathematical modeling suggests that culling programs fail because of high incidence of infection and infectiousness, the insensitivity of the diagnostic test to detect infectious dogs, and time delays between diagnosis and culling. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002 |
dc.date.accessioned.fl_str_mv |
2016-01-26T11:43:19Z |
dc.date.available.fl_str_mv |
2016-01-26T11:43:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COURTENAY, Orin et al. Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. The Journal of Infectious Diseases, v. 189, n. 9, p. 1314-1320, 2002 |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/1040 |
dc.identifier.issn.-.fl_str_mv |
0022-1899 |
identifier_str_mv |
COURTENAY, Orin et al. Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. The Journal of Infectious Diseases, v. 189, n. 9, p. 1314-1320, 2002 0022-1899 |
url |
https://patua.iec.gov.br/handle/iec/1040 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
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