A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3274 |
Resumo: | Background: Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortanttetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction. Methods: Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines. Results: From 517 potential cases identified, 476 (92 per cent) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89 per cent of cases aged 1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children 2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged 1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65 per cent). Most cases (88 per cent) made a complete recovery, but 13 (3 per cent) died. No clear seasonal pattern of IS cases emerged. Conclusions: This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies. |
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Sáez-Llorens, XavierVelázquez, F. RaulLopez, PioEspinoza, FelixLinhares, Alexandre da CostaAbate, Héctor JoséNuñez, ErnestoVenegas, GuillermoVergara, RodrigoJimenez, Ana LRivera, MaribelAranza, CarlosRichardson, VestaMacias-Parra, MercedesPalacios, Guillermo RuizRivera, LuizOrtega-Barria, EduardoCervantes, YolandaRuttimann, RicardoRubio, PilarAcosta, Camilo JNewbern, ClaireVerstraeten, ThomasBreuer, Thomas2018-07-20T12:49:03Z2018-07-20T12:49:03Z2013SÁEZ-LLORENS, Xavier et al. A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data. BMC Gastroenterology, v. 13, n. 95, p. 1-8, 2013. DOI: https://doi.org/10.1186/1471-230X-13-95. Disponível em: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-13-95.1471-230Xhttps://patua.iec.gov.br/handle/iec/327410.1186/1471-230X-13-95Background: Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortanttetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction. Methods: Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines. Results: From 517 potential cases identified, 476 (92 per cent) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89 per cent of cases aged 1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children 2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged 1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65 per cent). Most cases (88 per cent) made a complete recovery, but 13 (3 per cent) died. No clear seasonal pattern of IS cases emerged. Conclusions: This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies.Hospital del Niño. Infectious Disease Department. Ciudad de Panamá, Panama.Instituto Mexicano del Seguro Social. Medical Research Unit on Infectious Diseases. CMN-SXXI. Mexico City, Mexico.Centro de Estudios en Infectologia Pediatrica. Clinica Materno Infantil Los Farallones. Cali, Colombia.Universidad Nacional Autónoma de Nicaragua. Edificio Central. Leόn, Nicaragua.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Hospital Dr. Humberto Notti. Villa Nueva de Guaymallén, Mendoza, ArgentinaUniversidad de Concepción. Concepción, Chile.Universidad de Concepción. Concepción, Chile.Universidad de Valparaíso. Escuela de Medicina. Valparaíso, Chile.Hospital Nacional de Niños. Paseo Colón, San José, Costa Rica.Organización para el Desarrollo y la Investigación Salud en Honduras. Colonia Humuya, Tegucigalpa, Honduras.Hospital General de Tlanepantla “Valle Ceylán”. Tlanepantla, Mexico.Hospital Infantil de Mexico. Calle Dr. Márquez . México DF, Mexico / Ministry of Health. National Center for Child and Adolescent Health. Colonia Merced Gomez, Mexico DF, Mexico.Instituto Nacional de Pediatría. México DF, Mexico.Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico DF, Mexico.Hospital Maternidad Nuestra Sra de la Altagracia. Santo Domingo, DN, República Dominicana.Fundación para el Avance de la Investigación Clínica y Translacional, Consultorios Médicos América. Vía España, Carrasquilla, Panama / GlaxoSmithKline Vaccines. Clayton, Panama.GlaxoSmithKline Vaccines México. México DF, Mexico.GlaxoSmithKline Vaccines Argentina. Buenos Aires, Argentina / Independent Medical Professional. Buenos Aires, Argentina.GlaxoSmithKline Vaccines Costa Rica. San Jose, Costa Rica / GlaxoSmithKline Vaccines. Ciudad del Saber, Clayton, Panama.GlaxoSmithKline Vaccines. Philadelphia, USA / Merck & Co., Global Health Outcomes Vaccines. Philadelphia, PA, USA.GlaxoSmithKline Vaccines. Rixensart, Belgium / Philadelphia Department of Public Health. Philadelphia, USA.GlaxoSmithKline Vaccines. Rixensart, Belgium / P95 Excellence in Pharmacovigilance and Epidemiology, Leuven, Belgium.GlaxoSmithKline Vaccines. Rixensart, Belgium / GlaxoSmithKline Vaccines, Parc de la Noire Epine. Wavre, Belgium.engBioMed CentralA multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance datainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIntussuscepção / epidemiologiaRotavírusLactenteVacinaçãoVigilância EpidemiológicaAmérica Latina / epidemiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALA multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.pdfA multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.pdfapplication/pdf358614https://patua.iec.gov.br/bitstreams/8678d14c-792f-4c58-8e01-1fcc0c41f764/downloadfd86d88fc88cad416283b481165ae7f8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/07938edb-952b-4583-8a4c-7e52402eef06/download52f1732ea66fbd1123abe39f5373b797MD52TEXTA multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.pdf.txtA multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.pdf.txtExtracted texttext/plain77696https://patua.iec.gov.br/bitstreams/da402168-c63f-4768-8b49-dc5e54847fa5/download45bb038ec9b6c9e20c477e29aef1b0b0MD55THUMBNAILA multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.pdf.jpgA multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.pdf.jpgGenerated Thumbnailimage/jpeg5396https://patua.iec.gov.br/bitstreams/a807b1cf-ddae-4d13-8f4d-52bb234f237b/download47c10cd54344ecdbc82b8a6f47537b1aMD56iec/32742022-10-20 23:38:04.424oai:patua.iec.gov.br:iec/3274https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T23:38:04Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data |
title |
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data |
spellingShingle |
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data Sáez-Llorens, Xavier Intussuscepção / epidemiologia Rotavírus Lactente Vacinação Vigilância Epidemiológica América Latina / epidemiologia |
title_short |
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data |
title_full |
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data |
title_fullStr |
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data |
title_full_unstemmed |
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data |
title_sort |
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data |
author |
Sáez-Llorens, Xavier |
author_facet |
Sáez-Llorens, Xavier Velázquez, F. Raul Lopez, Pio Espinoza, Felix Linhares, Alexandre da Costa Abate, Héctor José Nuñez, Ernesto Venegas, Guillermo Vergara, Rodrigo Jimenez, Ana L Rivera, Maribel Aranza, Carlos Richardson, Vesta Macias-Parra, Mercedes Palacios, Guillermo Ruiz Rivera, Luiz Ortega-Barria, Eduardo Cervantes, Yolanda Ruttimann, Ricardo Rubio, Pilar Acosta, Camilo J Newbern, Claire Verstraeten, Thomas Breuer, Thomas |
author_role |
author |
author2 |
Velázquez, F. Raul Lopez, Pio Espinoza, Felix Linhares, Alexandre da Costa Abate, Héctor José Nuñez, Ernesto Venegas, Guillermo Vergara, Rodrigo Jimenez, Ana L Rivera, Maribel Aranza, Carlos Richardson, Vesta Macias-Parra, Mercedes Palacios, Guillermo Ruiz Rivera, Luiz Ortega-Barria, Eduardo Cervantes, Yolanda Ruttimann, Ricardo Rubio, Pilar Acosta, Camilo J Newbern, Claire Verstraeten, Thomas Breuer, Thomas |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sáez-Llorens, Xavier Velázquez, F. Raul Lopez, Pio Espinoza, Felix Linhares, Alexandre da Costa Abate, Héctor José Nuñez, Ernesto Venegas, Guillermo Vergara, Rodrigo Jimenez, Ana L Rivera, Maribel Aranza, Carlos Richardson, Vesta Macias-Parra, Mercedes Palacios, Guillermo Ruiz Rivera, Luiz Ortega-Barria, Eduardo Cervantes, Yolanda Ruttimann, Ricardo Rubio, Pilar Acosta, Camilo J Newbern, Claire Verstraeten, Thomas Breuer, Thomas |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Intussuscepção / epidemiologia Rotavírus Lactente Vacinação Vigilância Epidemiológica América Latina / epidemiologia |
topic |
Intussuscepção / epidemiologia Rotavírus Lactente Vacinação Vigilância Epidemiológica América Latina / epidemiologia |
dc.subject.decsPrimary.none.fl_str_mv |
|
description |
Background: Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortanttetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction. Methods: Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines. Results: From 517 potential cases identified, 476 (92 per cent) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89 per cent of cases aged 1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children 2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged 1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65 per cent). Most cases (88 per cent) made a complete recovery, but 13 (3 per cent) died. No clear seasonal pattern of IS cases emerged. Conclusions: This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2018-07-20T12:49:03Z |
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2018-07-20T12:49:03Z |
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dc.identifier.citation.fl_str_mv |
SÁEZ-LLORENS, Xavier et al. A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data. BMC Gastroenterology, v. 13, n. 95, p. 1-8, 2013. DOI: https://doi.org/10.1186/1471-230X-13-95. Disponível em: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-13-95. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3274 |
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1471-230X |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/1471-230X-13-95 |
identifier_str_mv |
SÁEZ-LLORENS, Xavier et al. A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data. BMC Gastroenterology, v. 13, n. 95, p. 1-8, 2013. DOI: https://doi.org/10.1186/1471-230X-13-95. Disponível em: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-13-95. 1471-230X 10.1186/1471-230X-13-95 |
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BioMed Central |
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