The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional do IEN |
Texto Completo: | http://carpedien.ien.gov.br:8080/handle/ien/2320 |
Resumo: | Vascular embolization is an important clinical procedure, frequently used to reduce the size of a tumor, to facilitate the removal of a tumor during surgery or to define a treatment of tumor malformation. In addition, imaging is an important component for the evaluation and care of patients undergoing vascular embolization. Nowadays, during the embolization procedure, the radiologist uses the Angiography or Fluoroscopy (X-Ray images) technique to estimate devascularization, since only pathological examinations are able to show the exact location of the blockade and microspheres. SPECT imaging is widely used in Brazil and provides images of superior quality to the mentioned techniques. Therefore, radioactive polymeric microspheres can be used as radioembolization agents for SPECT imaging. This technique can improve the resolution of images and, consequently, the embolization procedure efficacy of uterine fibroids for example, by allowing the track of particles distribution in the veins and tumor, the homogeneity of this distribution and the end of the embolization procedure. In this work, we evaluate the copolymerization of 4-vinylphenol and vinyl acetate as a synthesis route for a new radioembolization agent. GPC analysis results showed that this comonomer presence improved the molar mass distribution. In addition, bulk polymerization tests and kinetic studies showed that the selected comonomer retards the reaction time, but does not decrease the conversion percentage. Indeed, this result points out the necessity of a comonomer chemical modification to improve yield results. |
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Carvalheira, LucianaInstituto de Engenharia Nuclear2018-05-15T17:37:45Z2018-05-15T17:37:45Z2017-10http://carpedien.ien.gov.br:8080/handle/ien/2320Submitted by Marcele Costal de Castro (costalcastro@gmail.com) on 2018-05-15T17:37:45Z No. of bitstreams: 1 ARTIGO INAC 41.pdf: 794968 bytes, checksum: 9023da032f89c242f0391bab2557d872 (MD5)Made available in DSpace on 2018-05-15T17:37:45Z (GMT). No. of bitstreams: 1 ARTIGO INAC 41.pdf: 794968 bytes, checksum: 9023da032f89c242f0391bab2557d872 (MD5) Previous issue date: 2017-10Vascular embolization is an important clinical procedure, frequently used to reduce the size of a tumor, to facilitate the removal of a tumor during surgery or to define a treatment of tumor malformation. In addition, imaging is an important component for the evaluation and care of patients undergoing vascular embolization. Nowadays, during the embolization procedure, the radiologist uses the Angiography or Fluoroscopy (X-Ray images) technique to estimate devascularization, since only pathological examinations are able to show the exact location of the blockade and microspheres. SPECT imaging is widely used in Brazil and provides images of superior quality to the mentioned techniques. Therefore, radioactive polymeric microspheres can be used as radioembolization agents for SPECT imaging. This technique can improve the resolution of images and, consequently, the embolization procedure efficacy of uterine fibroids for example, by allowing the track of particles distribution in the veins and tumor, the homogeneity of this distribution and the end of the embolization procedure. In this work, we evaluate the copolymerization of 4-vinylphenol and vinyl acetate as a synthesis route for a new radioembolization agent. GPC analysis results showed that this comonomer presence improved the molar mass distribution. In addition, bulk polymerization tests and kinetic studies showed that the selected comonomer retards the reaction time, but does not decrease the conversion percentage. Indeed, this result points out the necessity of a comonomer chemical modification to improve yield results.engInstituto de Engenharia NuclearIENBrasilRadioactive polimeric microspheresEmbolization procedureNuclear medicineThe synthesis of radioactive polymeric microspheres for spect imaging during embolization proceduresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectXIII ENANinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IENinstname:Instituto de Engenharia Nuclearinstacron:IENLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://carpedien.ien.gov.br:8080/xmlui/bitstream/ien/2320/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALARTIGO INAC 41.pdfARTIGO INAC 41.pdfapplication/pdf794968http://carpedien.ien.gov.br:8080/xmlui/bitstream/ien/2320/1/ARTIGO+INAC+41.pdf9023da032f89c242f0391bab2557d872MD51ien/2320oai:carpedien.ien.gov.br:ien/23202018-05-15 14:37:45.919Dspace IENlsales@ien.gov.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 |
dc.title.pt_BR.fl_str_mv |
The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures |
title |
The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures |
spellingShingle |
The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures Carvalheira, Luciana Radioactive polimeric microspheres Embolization procedure Nuclear medicine |
title_short |
The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures |
title_full |
The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures |
title_fullStr |
The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures |
title_full_unstemmed |
The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures |
title_sort |
The synthesis of radioactive polymeric microspheres for spect imaging during embolization procedures |
author |
Carvalheira, Luciana |
author_facet |
Carvalheira, Luciana Instituto de Engenharia Nuclear |
author_role |
author |
author2 |
Instituto de Engenharia Nuclear |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Carvalheira, Luciana Instituto de Engenharia Nuclear |
dc.subject.por.fl_str_mv |
Radioactive polimeric microspheres Embolization procedure Nuclear medicine |
topic |
Radioactive polimeric microspheres Embolization procedure Nuclear medicine |
dc.description.abstract.por.fl_txt_mv |
Vascular embolization is an important clinical procedure, frequently used to reduce the size of a tumor, to facilitate the removal of a tumor during surgery or to define a treatment of tumor malformation. In addition, imaging is an important component for the evaluation and care of patients undergoing vascular embolization. Nowadays, during the embolization procedure, the radiologist uses the Angiography or Fluoroscopy (X-Ray images) technique to estimate devascularization, since only pathological examinations are able to show the exact location of the blockade and microspheres. SPECT imaging is widely used in Brazil and provides images of superior quality to the mentioned techniques. Therefore, radioactive polymeric microspheres can be used as radioembolization agents for SPECT imaging. This technique can improve the resolution of images and, consequently, the embolization procedure efficacy of uterine fibroids for example, by allowing the track of particles distribution in the veins and tumor, the homogeneity of this distribution and the end of the embolization procedure. In this work, we evaluate the copolymerization of 4-vinylphenol and vinyl acetate as a synthesis route for a new radioembolization agent. GPC analysis results showed that this comonomer presence improved the molar mass distribution. In addition, bulk polymerization tests and kinetic studies showed that the selected comonomer retards the reaction time, but does not decrease the conversion percentage. Indeed, this result points out the necessity of a comonomer chemical modification to improve yield results. |
description |
Vascular embolization is an important clinical procedure, frequently used to reduce the size of a tumor, to facilitate the removal of a tumor during surgery or to define a treatment of tumor malformation. In addition, imaging is an important component for the evaluation and care of patients undergoing vascular embolization. Nowadays, during the embolization procedure, the radiologist uses the Angiography or Fluoroscopy (X-Ray images) technique to estimate devascularization, since only pathological examinations are able to show the exact location of the blockade and microspheres. SPECT imaging is widely used in Brazil and provides images of superior quality to the mentioned techniques. Therefore, radioactive polymeric microspheres can be used as radioembolization agents for SPECT imaging. This technique can improve the resolution of images and, consequently, the embolization procedure efficacy of uterine fibroids for example, by allowing the track of particles distribution in the veins and tumor, the homogeneity of this distribution and the end of the embolization procedure. In this work, we evaluate the copolymerization of 4-vinylphenol and vinyl acetate as a synthesis route for a new radioembolization agent. GPC analysis results showed that this comonomer presence improved the molar mass distribution. In addition, bulk polymerization tests and kinetic studies showed that the selected comonomer retards the reaction time, but does not decrease the conversion percentage. Indeed, this result points out the necessity of a comonomer chemical modification to improve yield results. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-10 |
dc.date.accessioned.fl_str_mv |
2018-05-15T17:37:45Z |
dc.date.available.fl_str_mv |
2018-05-15T17:37:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.uri.fl_str_mv |
http://carpedien.ien.gov.br:8080/handle/ien/2320 |
url |
http://carpedien.ien.gov.br:8080/handle/ien/2320 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Instituto de Engenharia Nuclear |
dc.publisher.initials.fl_str_mv |
IEN |
dc.publisher.country.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
Instituto de Engenharia Nuclear |
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IEN |
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IEN |
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