EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW

Detalhes bibliográficos
Autor(a) principal: Diógenes Guimarães de Lima Menezes, Eduarda
Data de Publicação: 2022
Outros Autores: Costa, Ana Carolina de Figueiredo, de Sousa Neto , José Bonifácio, Maques, Joyce Alves, Santos, Marcelo Januzzi
Tipo de documento: Artigo
Idioma: por
Título da fonte: Health and Society
Texto Completo: https://www.periodicojs.com.br/index.php/hs/article/view/795
Resumo: Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting.
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spelling EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEWEFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEWPreenchedores faciais; Polímeros;Rejuvenescimento; Idade.Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting.Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting.Editora Acadêmica Periodicojs2022-09-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.periodicojs.com.br/index.php/hs/article/view/79510.51249/hs.v2i04.795Health and Society; Vol. 2 No. 04 (2022); 226-254Health and Society; v. 2 n. 04 (2022); 226-2542763-572410.51249/hs.v2i04reponame:Health and Societyinstname:Instituto de Ensino e Pesquisa Periodicojsinstacron:IEPPporhttps://www.periodicojs.com.br/index.php/hs/article/view/795/727Copyright (c) 2022 Eduarda Diógenes Guimarães de Lima Menezes, Ana Carolina de Figueiredo Costa, José Bonifácio de Sousa Neto , Joyce Alves Maques, Marcelo Januzzi Santoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDiógenes Guimarães de Lima Menezes, Eduarda Costa, Ana Carolina de Figueiredode Sousa Neto , José BonifácioMaques, Joyce AlvesSantos, Marcelo Januzzi 2022-09-02T22:24:24Zoai:ojs.pkp.sfu.ca:article/795Revistahttps://www.periodicojs.com.br/index.php/hs/PRIhttps://www.periodicojs.com.br/index.php/hs/oaijournalofhealthandsociety@gmail.com || periodicojs@gmail.com2763-57242763-5724opendoar:2022-09-02T22:24:24Health and Society - Instituto de Ensino e Pesquisa Periodicojsfalse
dc.title.none.fl_str_mv EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
title EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
spellingShingle EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
Diógenes Guimarães de Lima Menezes, Eduarda
Preenchedores faciais; Polímeros;
Rejuvenescimento; Idade.
title_short EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
title_full EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
title_fullStr EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
title_full_unstemmed EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
title_sort EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
author Diógenes Guimarães de Lima Menezes, Eduarda
author_facet Diógenes Guimarães de Lima Menezes, Eduarda
Costa, Ana Carolina de Figueiredo
de Sousa Neto , José Bonifácio
Maques, Joyce Alves
Santos, Marcelo Januzzi
author_role author
author2 Costa, Ana Carolina de Figueiredo
de Sousa Neto , José Bonifácio
Maques, Joyce Alves
Santos, Marcelo Januzzi
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Diógenes Guimarães de Lima Menezes, Eduarda
Costa, Ana Carolina de Figueiredo
de Sousa Neto , José Bonifácio
Maques, Joyce Alves
Santos, Marcelo Januzzi
dc.subject.por.fl_str_mv Preenchedores faciais; Polímeros;
Rejuvenescimento; Idade.
topic Preenchedores faciais; Polímeros;
Rejuvenescimento; Idade.
description Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-02
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.periodicojs.com.br/index.php/hs/article/view/795
10.51249/hs.v2i04.795
url https://www.periodicojs.com.br/index.php/hs/article/view/795
identifier_str_mv 10.51249/hs.v2i04.795
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.periodicojs.com.br/index.php/hs/article/view/795/727
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora Acadêmica Periodicojs
publisher.none.fl_str_mv Editora Acadêmica Periodicojs
dc.source.none.fl_str_mv Health and Society; Vol. 2 No. 04 (2022); 226-254
Health and Society; v. 2 n. 04 (2022); 226-254
2763-5724
10.51249/hs.v2i04
reponame:Health and Society
instname:Instituto de Ensino e Pesquisa Periodicojs
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instname_str Instituto de Ensino e Pesquisa Periodicojs
instacron_str IEPP
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reponame_str Health and Society
collection Health and Society
repository.name.fl_str_mv Health and Society - Instituto de Ensino e Pesquisa Periodicojs
repository.mail.fl_str_mv journalofhealthandsociety@gmail.com || periodicojs@gmail.com
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