EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Health and Society |
Texto Completo: | https://www.periodicojs.com.br/index.php/hs/article/view/795 |
Resumo: | Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting. |
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EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEWEFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEWPreenchedores faciais; Polímeros;Rejuvenescimento; Idade.Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting.Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting.Editora Acadêmica Periodicojs2022-09-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.periodicojs.com.br/index.php/hs/article/view/79510.51249/hs.v2i04.795Health and Society; Vol. 2 No. 04 (2022); 226-254Health and Society; v. 2 n. 04 (2022); 226-2542763-572410.51249/hs.v2i04reponame:Health and Societyinstname:Instituto de Ensino e Pesquisa Periodicojsinstacron:IEPPporhttps://www.periodicojs.com.br/index.php/hs/article/view/795/727Copyright (c) 2022 Eduarda Diógenes Guimarães de Lima Menezes, Ana Carolina de Figueiredo Costa, José Bonifácio de Sousa Neto , Joyce Alves Maques, Marcelo Januzzi Santoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDiógenes Guimarães de Lima Menezes, Eduarda Costa, Ana Carolina de Figueiredode Sousa Neto , José BonifácioMaques, Joyce AlvesSantos, Marcelo Januzzi 2022-09-02T22:24:24Zoai:ojs.pkp.sfu.ca:article/795Revistahttps://www.periodicojs.com.br/index.php/hs/PRIhttps://www.periodicojs.com.br/index.php/hs/oaijournalofhealthandsociety@gmail.com || periodicojs@gmail.com2763-57242763-5724opendoar:2022-09-02T22:24:24Health and Society - Instituto de Ensino e Pesquisa Periodicojsfalse |
dc.title.none.fl_str_mv |
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW |
title |
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW |
spellingShingle |
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW Diógenes Guimarães de Lima Menezes, Eduarda Preenchedores faciais; Polímeros; Rejuvenescimento; Idade. |
title_short |
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW |
title_full |
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW |
title_fullStr |
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW |
title_full_unstemmed |
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW |
title_sort |
EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION:: A SYSTEMATIC REVIEW |
author |
Diógenes Guimarães de Lima Menezes, Eduarda |
author_facet |
Diógenes Guimarães de Lima Menezes, Eduarda Costa, Ana Carolina de Figueiredo de Sousa Neto , José Bonifácio Maques, Joyce Alves Santos, Marcelo Januzzi |
author_role |
author |
author2 |
Costa, Ana Carolina de Figueiredo de Sousa Neto , José Bonifácio Maques, Joyce Alves Santos, Marcelo Januzzi |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Diógenes Guimarães de Lima Menezes, Eduarda Costa, Ana Carolina de Figueiredo de Sousa Neto , José Bonifácio Maques, Joyce Alves Santos, Marcelo Januzzi |
dc.subject.por.fl_str_mv |
Preenchedores faciais; Polímeros; Rejuvenescimento; Idade. |
topic |
Preenchedores faciais; Polímeros; Rejuvenescimento; Idade. |
description |
Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.periodicojs.com.br/index.php/hs/article/view/795 10.51249/hs.v2i04.795 |
url |
https://www.periodicojs.com.br/index.php/hs/article/view/795 |
identifier_str_mv |
10.51249/hs.v2i04.795 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.periodicojs.com.br/index.php/hs/article/view/795/727 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora Acadêmica Periodicojs |
publisher.none.fl_str_mv |
Editora Acadêmica Periodicojs |
dc.source.none.fl_str_mv |
Health and Society; Vol. 2 No. 04 (2022); 226-254 Health and Society; v. 2 n. 04 (2022); 226-254 2763-5724 10.51249/hs.v2i04 reponame:Health and Society instname:Instituto de Ensino e Pesquisa Periodicojs instacron:IEPP |
instname_str |
Instituto de Ensino e Pesquisa Periodicojs |
instacron_str |
IEPP |
institution |
IEPP |
reponame_str |
Health and Society |
collection |
Health and Society |
repository.name.fl_str_mv |
Health and Society - Instituto de Ensino e Pesquisa Periodicojs |
repository.mail.fl_str_mv |
journalofhealthandsociety@gmail.com || periodicojs@gmail.com |
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1797047896220106752 |