VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES

Detalhes bibliográficos
Autor(a) principal: Verde, Ignacio
Data de Publicação: 2021
Outros Autores: Filipe, Juliana
Tipo de documento: Artigo
Idioma: por
Título da fonte: Health and Society
Texto Completo: https://www.periodicojs.com.br/index.php/hs/article/view/295
Resumo: Octylmethoxycinnamate (OMC) is a filter for ultraviolet B radiation used in sunscreens to protect skin. There is some evidence about the OMC activity as endocrine disruptor concerning a possible estrogenic activity, but its vascular effects were not still analyzed. The objective was to evaluate the non-genomic effects of the OMC on human umbilical artery (HUA) without endothelium. By mean of an organ bath system, HUA rings without endothelium were contracted by 5-hydroxytryptamine (5HT; 1µM) or by depolarization with KCl (60mM), and the effect of different concentrations of OMC was analyzed. The OMC elicits vasodilator effect on HUA without endothelium contracted by 5-HT (1μM) and by KCl (60mM). The effect was similar for the two contractile agents used. Here, we established that the OMC causes vasodilation of human arteries. This effect is analogous to the non-genomic effect caused by estradiol (E2), which occurs also by and endothelial-independent mechanism.
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spelling VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIESVASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIESOctylmethoxycinnamate, Endocrine disruptor, Human umbilical artery, EstrogenOctylmethoxycinnamate (OMC) is a filter for ultraviolet B radiation used in sunscreens to protect skin. There is some evidence about the OMC activity as endocrine disruptor concerning a possible estrogenic activity, but its vascular effects were not still analyzed. The objective was to evaluate the non-genomic effects of the OMC on human umbilical artery (HUA) without endothelium. By mean of an organ bath system, HUA rings without endothelium were contracted by 5-hydroxytryptamine (5HT; 1µM) or by depolarization with KCl (60mM), and the effect of different concentrations of OMC was analyzed. The OMC elicits vasodilator effect on HUA without endothelium contracted by 5-HT (1μM) and by KCl (60mM). The effect was similar for the two contractile agents used. Here, we established that the OMC causes vasodilation of human arteries. This effect is analogous to the non-genomic effect caused by estradiol (E2), which occurs also by and endothelial-independent mechanism.Octylmethoxycinnamate (OMC) is a filter for ultraviolet B radiation used in sunscreens to protect skin. There is some evidence about the OMC activity as endocrine disruptor concerning a possible estrogenic activity, but its vascular effects were not still analyzed. The objective was to evaluate the non-genomic effects of the OMC on human umbilical artery (HUA) without endothelium. By mean of an organ bath system, HUA rings without endothelium were contracted by 5-hydroxytryptamine (5HT; 1µM) or by depolarization with KCl (60mM), and the effect of different concentrations of OMC was analyzed. The OMC elicits vasodilator effect on HUA without endothelium contracted by 5-HT (1μM) and by KCl (60mM). The effect was similar for the two contractile agents used. Here, we established that the OMC causes vasodilation of human arteries. This effect is analogous to the non-genomic effect caused by estradiol (E2), which occurs also by and endothelial-independent mechanism.Editora Acadêmica Periodicojs2021-06-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.periodicojs.com.br/index.php/hs/article/view/29510.51249/hes01.02.2021.295Health and Society; Vol. 1 No. 02 (2021)Health and Society; v. 1 n. 02 (2021)2763-572410.51249/hs.v1i02reponame:Health and Societyinstname:Instituto de Ensino e Pesquisa Periodicojsinstacron:IEPPporhttps://www.periodicojs.com.br/index.php/hs/article/view/295/188Copyright (c) 2021 Health and Societyinfo:eu-repo/semantics/openAccessVerde, IgnacioFilipe, Juliana 2022-01-11T13:28:45Zoai:ojs.pkp.sfu.ca:article/295Revistahttps://www.periodicojs.com.br/index.php/hs/PRIhttps://www.periodicojs.com.br/index.php/hs/oaijournalofhealthandsociety@gmail.com || periodicojs@gmail.com2763-57242763-5724opendoar:2022-01-11T13:28:45Health and Society - Instituto de Ensino e Pesquisa Periodicojsfalse
dc.title.none.fl_str_mv VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
title VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
spellingShingle VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
Verde, Ignacio
Octylmethoxycinnamate, Endocrine disruptor, Human umbilical artery, Estrogen
title_short VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
title_full VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
title_fullStr VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
title_full_unstemmed VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
title_sort VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
author Verde, Ignacio
author_facet Verde, Ignacio
Filipe, Juliana
author_role author
author2 Filipe, Juliana
author2_role author
dc.contributor.author.fl_str_mv Verde, Ignacio
Filipe, Juliana
dc.subject.por.fl_str_mv Octylmethoxycinnamate, Endocrine disruptor, Human umbilical artery, Estrogen
topic Octylmethoxycinnamate, Endocrine disruptor, Human umbilical artery, Estrogen
description Octylmethoxycinnamate (OMC) is a filter for ultraviolet B radiation used in sunscreens to protect skin. There is some evidence about the OMC activity as endocrine disruptor concerning a possible estrogenic activity, but its vascular effects were not still analyzed. The objective was to evaluate the non-genomic effects of the OMC on human umbilical artery (HUA) without endothelium. By mean of an organ bath system, HUA rings without endothelium were contracted by 5-hydroxytryptamine (5HT; 1µM) or by depolarization with KCl (60mM), and the effect of different concentrations of OMC was analyzed. The OMC elicits vasodilator effect on HUA without endothelium contracted by 5-HT (1μM) and by KCl (60mM). The effect was similar for the two contractile agents used. Here, we established that the OMC causes vasodilation of human arteries. This effect is analogous to the non-genomic effect caused by estradiol (E2), which occurs also by and endothelial-independent mechanism.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.periodicojs.com.br/index.php/hs/article/view/295
10.51249/hes01.02.2021.295
url https://www.periodicojs.com.br/index.php/hs/article/view/295
identifier_str_mv 10.51249/hes01.02.2021.295
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.periodicojs.com.br/index.php/hs/article/view/295/188
dc.rights.driver.fl_str_mv Copyright (c) 2021 Health and Society
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Health and Society
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora Acadêmica Periodicojs
publisher.none.fl_str_mv Editora Acadêmica Periodicojs
dc.source.none.fl_str_mv Health and Society; Vol. 1 No. 02 (2021)
Health and Society; v. 1 n. 02 (2021)
2763-5724
10.51249/hs.v1i02
reponame:Health and Society
instname:Instituto de Ensino e Pesquisa Periodicojs
instacron:IEPP
instname_str Instituto de Ensino e Pesquisa Periodicojs
instacron_str IEPP
institution IEPP
reponame_str Health and Society
collection Health and Society
repository.name.fl_str_mv Health and Society - Instituto de Ensino e Pesquisa Periodicojs
repository.mail.fl_str_mv journalofhealthandsociety@gmail.com || periodicojs@gmail.com
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