VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Health and Society |
Texto Completo: | https://www.periodicojs.com.br/index.php/hs/article/view/295 |
Resumo: | Octylmethoxycinnamate (OMC) is a filter for ultraviolet B radiation used in sunscreens to protect skin. There is some evidence about the OMC activity as endocrine disruptor concerning a possible estrogenic activity, but its vascular effects were not still analyzed. The objective was to evaluate the non-genomic effects of the OMC on human umbilical artery (HUA) without endothelium. By mean of an organ bath system, HUA rings without endothelium were contracted by 5-hydroxytryptamine (5HT; 1µM) or by depolarization with KCl (60mM), and the effect of different concentrations of OMC was analyzed. The OMC elicits vasodilator effect on HUA without endothelium contracted by 5-HT (1μM) and by KCl (60mM). The effect was similar for the two contractile agents used. Here, we established that the OMC causes vasodilation of human arteries. This effect is analogous to the non-genomic effect caused by estradiol (E2), which occurs also by and endothelial-independent mechanism. |
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VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIESVASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIESOctylmethoxycinnamate, Endocrine disruptor, Human umbilical artery, EstrogenOctylmethoxycinnamate (OMC) is a filter for ultraviolet B radiation used in sunscreens to protect skin. There is some evidence about the OMC activity as endocrine disruptor concerning a possible estrogenic activity, but its vascular effects were not still analyzed. The objective was to evaluate the non-genomic effects of the OMC on human umbilical artery (HUA) without endothelium. By mean of an organ bath system, HUA rings without endothelium were contracted by 5-hydroxytryptamine (5HT; 1µM) or by depolarization with KCl (60mM), and the effect of different concentrations of OMC was analyzed. The OMC elicits vasodilator effect on HUA without endothelium contracted by 5-HT (1μM) and by KCl (60mM). The effect was similar for the two contractile agents used. Here, we established that the OMC causes vasodilation of human arteries. This effect is analogous to the non-genomic effect caused by estradiol (E2), which occurs also by and endothelial-independent mechanism.Octylmethoxycinnamate (OMC) is a filter for ultraviolet B radiation used in sunscreens to protect skin. There is some evidence about the OMC activity as endocrine disruptor concerning a possible estrogenic activity, but its vascular effects were not still analyzed. The objective was to evaluate the non-genomic effects of the OMC on human umbilical artery (HUA) without endothelium. By mean of an organ bath system, HUA rings without endothelium were contracted by 5-hydroxytryptamine (5HT; 1µM) or by depolarization with KCl (60mM), and the effect of different concentrations of OMC was analyzed. The OMC elicits vasodilator effect on HUA without endothelium contracted by 5-HT (1μM) and by KCl (60mM). The effect was similar for the two contractile agents used. Here, we established that the OMC causes vasodilation of human arteries. This effect is analogous to the non-genomic effect caused by estradiol (E2), which occurs also by and endothelial-independent mechanism.Editora Acadêmica Periodicojs2021-06-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.periodicojs.com.br/index.php/hs/article/view/29510.51249/hes01.02.2021.295Health and Society; Vol. 1 No. 02 (2021)Health and Society; v. 1 n. 02 (2021)2763-572410.51249/hs.v1i02reponame:Health and Societyinstname:Instituto de Ensino e Pesquisa Periodicojsinstacron:IEPPporhttps://www.periodicojs.com.br/index.php/hs/article/view/295/188Copyright (c) 2021 Health and Societyinfo:eu-repo/semantics/openAccessVerde, IgnacioFilipe, Juliana 2022-01-11T13:28:45Zoai:ojs.pkp.sfu.ca:article/295Revistahttps://www.periodicojs.com.br/index.php/hs/PRIhttps://www.periodicojs.com.br/index.php/hs/oaijournalofhealthandsociety@gmail.com || periodicojs@gmail.com2763-57242763-5724opendoar:2022-01-11T13:28:45Health and Society - Instituto de Ensino e Pesquisa Periodicojsfalse |
dc.title.none.fl_str_mv |
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES |
title |
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES |
spellingShingle |
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES Verde, Ignacio Octylmethoxycinnamate, Endocrine disruptor, Human umbilical artery, Estrogen |
title_short |
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES |
title_full |
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES |
title_fullStr |
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES |
title_full_unstemmed |
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES |
title_sort |
VASODILATOR EFFECT OF OCTYLMETHOXYCINNAMATE ON HUMAN UMBILICAL ARTERIES |
author |
Verde, Ignacio |
author_facet |
Verde, Ignacio Filipe, Juliana |
author_role |
author |
author2 |
Filipe, Juliana |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Verde, Ignacio Filipe, Juliana |
dc.subject.por.fl_str_mv |
Octylmethoxycinnamate, Endocrine disruptor, Human umbilical artery, Estrogen |
topic |
Octylmethoxycinnamate, Endocrine disruptor, Human umbilical artery, Estrogen |
description |
Octylmethoxycinnamate (OMC) is a filter for ultraviolet B radiation used in sunscreens to protect skin. There is some evidence about the OMC activity as endocrine disruptor concerning a possible estrogenic activity, but its vascular effects were not still analyzed. The objective was to evaluate the non-genomic effects of the OMC on human umbilical artery (HUA) without endothelium. By mean of an organ bath system, HUA rings without endothelium were contracted by 5-hydroxytryptamine (5HT; 1µM) or by depolarization with KCl (60mM), and the effect of different concentrations of OMC was analyzed. The OMC elicits vasodilator effect on HUA without endothelium contracted by 5-HT (1μM) and by KCl (60mM). The effect was similar for the two contractile agents used. Here, we established that the OMC causes vasodilation of human arteries. This effect is analogous to the non-genomic effect caused by estradiol (E2), which occurs also by and endothelial-independent mechanism. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.periodicojs.com.br/index.php/hs/article/view/295 10.51249/hes01.02.2021.295 |
url |
https://www.periodicojs.com.br/index.php/hs/article/view/295 |
identifier_str_mv |
10.51249/hes01.02.2021.295 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.periodicojs.com.br/index.php/hs/article/view/295/188 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Health and Society info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Health and Society |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora Acadêmica Periodicojs |
publisher.none.fl_str_mv |
Editora Acadêmica Periodicojs |
dc.source.none.fl_str_mv |
Health and Society; Vol. 1 No. 02 (2021) Health and Society; v. 1 n. 02 (2021) 2763-5724 10.51249/hs.v1i02 reponame:Health and Society instname:Instituto de Ensino e Pesquisa Periodicojs instacron:IEPP |
instname_str |
Instituto de Ensino e Pesquisa Periodicojs |
instacron_str |
IEPP |
institution |
IEPP |
reponame_str |
Health and Society |
collection |
Health and Society |
repository.name.fl_str_mv |
Health and Society - Instituto de Ensino e Pesquisa Periodicojs |
repository.mail.fl_str_mv |
journalofhealthandsociety@gmail.com || periodicojs@gmail.com |
_version_ |
1797047895616126976 |