THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION
Autor(a) principal: | |
---|---|
Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Health and Society |
Texto Completo: | https://www.periodicojs.com.br/index.php/hs/article/view/1928 |
Resumo: | Progressive memory loss is one of the neurological sequelae reported in patients who have recovered from COVID-19. The APOE gene, which encodes apolipoprotein E, has been associated with neurodegenerative disorders and may play a role in the vulnerability of certain individuals to brain damage caused by coronavirus infection. Understanding this correlation can provide important insights for the treatment and follow-up of post-COVID-19 patients. The objectives of this study are to investigate the association between the APOE gene and progressive memory loss in post-COVID-19 patients, to assess whether the presence of certain APOE gene variants is related to a higher risk of developing progressive memory loss after infection, and to identify possible mechanisms by which the APOE gene may influence vulnerability to memory loss in patients with a history of COVID-19. The methodology in question is a bibliographic review, with a narrative and exploratory method, using the PubMed, Scopus, Web of Science and Google Scholar databases, using the health sciences descriptors “ApoE Gene and Covid-19”, “Covid-19 and Genetics”, “Covid-19 and Alzheimer’s Disease” and “Covid-19 and Memory Loss”, generating a total of 78 articles, 11 of which were selected for this study. In addition, guiding questions were outlined, as well as the use of inclusion and exclusion criteria for better performance. Studies have suggested that carriers of the APOE4 genetic variant have a higher risk of developing neurodegenerative diseases, such as Alzheimer’s disease. This variant may also be associated with an increased risk of brain damage in COVID-19 patients. The presence of the APOE4 gene may influence the inflammatory response and neuronal regeneration after infection, contributing to progressive memory loss. In addition, the severity of the COVID-19 infection and the presence of neurological complications during the disease may affect the risk of developing progressive memory loss in post-COVID-19 patients. Factors such as age, comorbidities and immune response may also play a role in this correlation. The correlation between the APOE gene and progressive memory loss in post-COVID-19 patients highlights the importance of genetic and clinical studies to identify individuals at greater risk of developing neurological sequelae after infection. Understanding the mechanisms underlying this correlation could lead to the development of more effective prevention and treatment strategies for these patients. |
id |
IEPP-2_a9320fddab91927a3e24b5bdbd5a6d55 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/1928 |
network_acronym_str |
IEPP-2 |
network_name_str |
Health and Society |
repository_id_str |
|
spelling |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATIONCOVID-19; Memory Loss; Mutation; Alzheimer’s Disease and Public Health.Progressive memory loss is one of the neurological sequelae reported in patients who have recovered from COVID-19. The APOE gene, which encodes apolipoprotein E, has been associated with neurodegenerative disorders and may play a role in the vulnerability of certain individuals to brain damage caused by coronavirus infection. Understanding this correlation can provide important insights for the treatment and follow-up of post-COVID-19 patients. The objectives of this study are to investigate the association between the APOE gene and progressive memory loss in post-COVID-19 patients, to assess whether the presence of certain APOE gene variants is related to a higher risk of developing progressive memory loss after infection, and to identify possible mechanisms by which the APOE gene may influence vulnerability to memory loss in patients with a history of COVID-19. The methodology in question is a bibliographic review, with a narrative and exploratory method, using the PubMed, Scopus, Web of Science and Google Scholar databases, using the health sciences descriptors “ApoE Gene and Covid-19”, “Covid-19 and Genetics”, “Covid-19 and Alzheimer’s Disease” and “Covid-19 and Memory Loss”, generating a total of 78 articles, 11 of which were selected for this study. In addition, guiding questions were outlined, as well as the use of inclusion and exclusion criteria for better performance. Studies have suggested that carriers of the APOE4 genetic variant have a higher risk of developing neurodegenerative diseases, such as Alzheimer’s disease. This variant may also be associated with an increased risk of brain damage in COVID-19 patients. The presence of the APOE4 gene may influence the inflammatory response and neuronal regeneration after infection, contributing to progressive memory loss. In addition, the severity of the COVID-19 infection and the presence of neurological complications during the disease may affect the risk of developing progressive memory loss in post-COVID-19 patients. Factors such as age, comorbidities and immune response may also play a role in this correlation. The correlation between the APOE gene and progressive memory loss in post-COVID-19 patients highlights the importance of genetic and clinical studies to identify individuals at greater risk of developing neurological sequelae after infection. Understanding the mechanisms underlying this correlation could lead to the development of more effective prevention and treatment strategies for these patients.Editora Acadêmica Periodicojs2024-03-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.periodicojs.com.br/index.php/hs/article/view/192810.51249/hs.v4i02.1928Health and Society; Vol. 4 No. 02 (2024); 12 - 22Health and Society; v. 4 n. 02 (2024); 12 - 222763-572410.51249/hs.v4i02reponame:Health and Societyinstname:Instituto de Ensino e Pesquisa Periodicojsinstacron:IEPPporhttps://www.periodicojs.com.br/index.php/hs/article/view/1928/1708Copyright (c) 2024 João Pedro do Valle Varela, Andrezza Ferraço Perim, Bruno de Figueiredo Moutinho, Giselle Chebabe de Azevedo, Jacquelline Machado Pinto Nader, Beatriz Merçon Leal Reis, Eduarda Ferro Firme Pina, Elisa Spinassé Del Caro, Breno Abreu Almeida, Fabio Luiz Teixeira Fullyhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPedro do Valle Varela, João Ferraço Perim, Andrezza de Figueiredo Moutinho, Bruno Chebabe de Azevedo, Giselle Machado Pinto Nader, Jacquelline Merçon Leal Reis, Beatriz Ferro Firme Pina, Eduarda Spinassé Del Caro, Elisa Abreu Almeida, Breno Luiz Teixeira Fully, Fabio 2024-03-05T19:51:46Zoai:ojs.pkp.sfu.ca:article/1928Revistahttps://www.periodicojs.com.br/index.php/hs/PRIhttps://www.periodicojs.com.br/index.php/hs/oaijournalofhealthandsociety@gmail.com || periodicojs@gmail.com2763-57242763-5724opendoar:2024-03-05T19:51:46Health and Society - Instituto de Ensino e Pesquisa Periodicojsfalse |
dc.title.none.fl_str_mv |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION |
title |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION |
spellingShingle |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION Pedro do Valle Varela, João COVID-19; Memory Loss; Mutation; Alzheimer’s Disease and Public Health. |
title_short |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION |
title_full |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION |
title_fullStr |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION |
title_full_unstemmed |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION |
title_sort |
THE CORRELATION OF THE APOE GENE IN PATIENTS WITH PROGRESSIVE MEMORY LOSS AFTER COVID-19 CONTAMINATION |
author |
Pedro do Valle Varela, João |
author_facet |
Pedro do Valle Varela, João Ferraço Perim, Andrezza de Figueiredo Moutinho, Bruno Chebabe de Azevedo, Giselle Machado Pinto Nader, Jacquelline Merçon Leal Reis, Beatriz Ferro Firme Pina, Eduarda Spinassé Del Caro, Elisa Abreu Almeida, Breno Luiz Teixeira Fully, Fabio |
author_role |
author |
author2 |
Ferraço Perim, Andrezza de Figueiredo Moutinho, Bruno Chebabe de Azevedo, Giselle Machado Pinto Nader, Jacquelline Merçon Leal Reis, Beatriz Ferro Firme Pina, Eduarda Spinassé Del Caro, Elisa Abreu Almeida, Breno Luiz Teixeira Fully, Fabio |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pedro do Valle Varela, João Ferraço Perim, Andrezza de Figueiredo Moutinho, Bruno Chebabe de Azevedo, Giselle Machado Pinto Nader, Jacquelline Merçon Leal Reis, Beatriz Ferro Firme Pina, Eduarda Spinassé Del Caro, Elisa Abreu Almeida, Breno Luiz Teixeira Fully, Fabio |
dc.subject.por.fl_str_mv |
COVID-19; Memory Loss; Mutation; Alzheimer’s Disease and Public Health. |
topic |
COVID-19; Memory Loss; Mutation; Alzheimer’s Disease and Public Health. |
description |
Progressive memory loss is one of the neurological sequelae reported in patients who have recovered from COVID-19. The APOE gene, which encodes apolipoprotein E, has been associated with neurodegenerative disorders and may play a role in the vulnerability of certain individuals to brain damage caused by coronavirus infection. Understanding this correlation can provide important insights for the treatment and follow-up of post-COVID-19 patients. The objectives of this study are to investigate the association between the APOE gene and progressive memory loss in post-COVID-19 patients, to assess whether the presence of certain APOE gene variants is related to a higher risk of developing progressive memory loss after infection, and to identify possible mechanisms by which the APOE gene may influence vulnerability to memory loss in patients with a history of COVID-19. The methodology in question is a bibliographic review, with a narrative and exploratory method, using the PubMed, Scopus, Web of Science and Google Scholar databases, using the health sciences descriptors “ApoE Gene and Covid-19”, “Covid-19 and Genetics”, “Covid-19 and Alzheimer’s Disease” and “Covid-19 and Memory Loss”, generating a total of 78 articles, 11 of which were selected for this study. In addition, guiding questions were outlined, as well as the use of inclusion and exclusion criteria for better performance. Studies have suggested that carriers of the APOE4 genetic variant have a higher risk of developing neurodegenerative diseases, such as Alzheimer’s disease. This variant may also be associated with an increased risk of brain damage in COVID-19 patients. The presence of the APOE4 gene may influence the inflammatory response and neuronal regeneration after infection, contributing to progressive memory loss. In addition, the severity of the COVID-19 infection and the presence of neurological complications during the disease may affect the risk of developing progressive memory loss in post-COVID-19 patients. Factors such as age, comorbidities and immune response may also play a role in this correlation. The correlation between the APOE gene and progressive memory loss in post-COVID-19 patients highlights the importance of genetic and clinical studies to identify individuals at greater risk of developing neurological sequelae after infection. Understanding the mechanisms underlying this correlation could lead to the development of more effective prevention and treatment strategies for these patients. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-03-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.periodicojs.com.br/index.php/hs/article/view/1928 10.51249/hs.v4i02.1928 |
url |
https://www.periodicojs.com.br/index.php/hs/article/view/1928 |
identifier_str_mv |
10.51249/hs.v4i02.1928 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.periodicojs.com.br/index.php/hs/article/view/1928/1708 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora Acadêmica Periodicojs |
publisher.none.fl_str_mv |
Editora Acadêmica Periodicojs |
dc.source.none.fl_str_mv |
Health and Society; Vol. 4 No. 02 (2024); 12 - 22 Health and Society; v. 4 n. 02 (2024); 12 - 22 2763-5724 10.51249/hs.v4i02 reponame:Health and Society instname:Instituto de Ensino e Pesquisa Periodicojs instacron:IEPP |
instname_str |
Instituto de Ensino e Pesquisa Periodicojs |
instacron_str |
IEPP |
institution |
IEPP |
reponame_str |
Health and Society |
collection |
Health and Society |
repository.name.fl_str_mv |
Health and Society - Instituto de Ensino e Pesquisa Periodicojs |
repository.mail.fl_str_mv |
journalofhealthandsociety@gmail.com || periodicojs@gmail.com |
_version_ |
1797047895574183936 |