Controversies over the indication of chloroquine and hydroxychloroquine for the treatment of covid-19

• Autor(a) principal: Gomes, Anders Teixeira
• Data de Publicação: 2023
• Outros Autores: Nunes, Núbia da Silva Cardoso, Oliveira, Maria Alice dos Santos Almeida de, Oliveira , Maria Alice dos Santos Almeida de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Vértices (Campos dos Goitacazes. Online)
• Texto Completo: https://editoraessentia.iff.edu.br/index.php/vertices/article/view/17147
• topic: coronavírus; covid-19; cloroquina; hidroxicloroquina; azitromicina; coronavírus; covid-19; cloroquina; hidroxicloroquina; azitromicina; coronavirus; covid-19; chloroquine; hydroxychloroquine; azithromycin

The global health crisis caused by the new coronavirus pandemic represents a moment of uncertainty. Due to the rapid spread of the virus and the absence of an appropriate contingency plan, some drugs began to be used preventively: chloroquine, hydroxychloroquine, and azithromycin, especially in the fight against opportunistic infections such as pneumonia. However, the indication of these drugs quickly became controversial. The objective of this research was to conduct a literature review on the controversies of the indication of chloroquine and hydroxychloroquine, associated or not, to azithromycin for the treatment of covid-19. The methodology used was the narrative review of the literature conducted from March 2020 to March 2021. The different authors were unanimous in stating that due to the difficulties imposed, there are great barriers to proving the use of chloroquine and hydroxychloroquine, both due to the uncertainty of the research published so far and the dubious or even questionable quality of the methodologies used. It is concluded that to date there is no specific treatment for covid-19 due to the absence of robust results. Therefore, the scientific community will oppose the use of these two drugs until data from well-designed clinical trials are published, with a greater number of participants, clearer methodologies, and more consistent results.