Phytochemical profile and biological activities of Bromelia antiacantha extracts

Detalhes bibliográficos
Autor(a) principal: Rodrigues,K. F.
Data de Publicação: 2024
Outros Autores: Bitencourt,T. C., Núñez,J. G., Garcia,H. O., Buhl,B., Padilha,G. L., Ethur,E. M., Hoehne,L., Bruno,A. N., Freitas,E. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100225
Resumo: Abstract Reports from popular medicine usually act as a basis for the development of new drugs from natural compounds with therapeutic actions for serious diseases and prevalence such as cancer. Bromelia antiacantha Bertol. is a species of the Bromeliaceae family, considered an unconventional food plant, found in the south and midwest regions of Brazil. Despite the high nutritional content and pharmacological potential of its fruits, few scientific studies report its biological actions. Thus, this study evaluates the phytochemical profile of aqueous and ethanol extracts obtained from B. antiacantha fruits, as well as their possible antioxidant, antitumor, and cytotoxic activities. The aqueous extract exhibited phenolic compounds and flavonoids, while ethanol extracts indicated the presence of flavonoids and coumarin in their composition, regardless of the region of collection. The ethanolic extract demonstrated a more promising antioxidant effect than the aqueous extract and also induced a significant inhibition in the viability of human cervical cancer cells of the SiHa strain. In addition, treatment with both extracts did not alter the viability of non-tumor cells of the immortalized human keratinocyte lineage (HaCaT). These results bring new data about extracts obtained from a native plant, edible and traditionally used in popular medicine, opening new perspectives for its possible therapeutic application.
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spelling Phytochemical profile and biological activities of Bromelia antiacantha extractsBromelia Antiacanthacervical câncer cellsphytochemical profileSiHa lineageHaCaT cellsAbstract Reports from popular medicine usually act as a basis for the development of new drugs from natural compounds with therapeutic actions for serious diseases and prevalence such as cancer. Bromelia antiacantha Bertol. is a species of the Bromeliaceae family, considered an unconventional food plant, found in the south and midwest regions of Brazil. Despite the high nutritional content and pharmacological potential of its fruits, few scientific studies report its biological actions. Thus, this study evaluates the phytochemical profile of aqueous and ethanol extracts obtained from B. antiacantha fruits, as well as their possible antioxidant, antitumor, and cytotoxic activities. The aqueous extract exhibited phenolic compounds and flavonoids, while ethanol extracts indicated the presence of flavonoids and coumarin in their composition, regardless of the region of collection. The ethanolic extract demonstrated a more promising antioxidant effect than the aqueous extract and also induced a significant inhibition in the viability of human cervical cancer cells of the SiHa strain. In addition, treatment with both extracts did not alter the viability of non-tumor cells of the immortalized human keratinocyte lineage (HaCaT). These results bring new data about extracts obtained from a native plant, edible and traditionally used in popular medicine, opening new perspectives for its possible therapeutic application.Instituto Internacional de Ecologia2024-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100225Brazilian Journal of Biology v.84 2024reponame:Brazilian Journal of Biologyinstname:Instituto Internacional de Ecologia (IIE)instacron:IIE10.1590/1519-6984.255529info:eu-repo/semantics/openAccessRodrigues,K. F.Bitencourt,T. C.Núñez,J. G.Garcia,H. O.Buhl,B.Padilha,G. L.Ethur,E. M.Hoehne,L.Bruno,A. N.Freitas,E. M.eng2022-03-04T00:00:00Zoai:scielo:S1519-69842024000100225Revistahttps://www.scielo.br/j/bjb/https://old.scielo.br/oai/scielo-oai.phpbjb@bjb.com.br||bjb@bjb.com.br1678-43751519-6984opendoar:2022-03-04T00:00Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)false
dc.title.none.fl_str_mv Phytochemical profile and biological activities of Bromelia antiacantha extracts
title Phytochemical profile and biological activities of Bromelia antiacantha extracts
spellingShingle Phytochemical profile and biological activities of Bromelia antiacantha extracts
Rodrigues,K. F.
Bromelia Antiacantha
cervical câncer cells
phytochemical profile
SiHa lineage
HaCaT cells
title_short Phytochemical profile and biological activities of Bromelia antiacantha extracts
title_full Phytochemical profile and biological activities of Bromelia antiacantha extracts
title_fullStr Phytochemical profile and biological activities of Bromelia antiacantha extracts
title_full_unstemmed Phytochemical profile and biological activities of Bromelia antiacantha extracts
title_sort Phytochemical profile and biological activities of Bromelia antiacantha extracts
author Rodrigues,K. F.
author_facet Rodrigues,K. F.
Bitencourt,T. C.
Núñez,J. G.
Garcia,H. O.
Buhl,B.
Padilha,G. L.
Ethur,E. M.
Hoehne,L.
Bruno,A. N.
Freitas,E. M.
author_role author
author2 Bitencourt,T. C.
Núñez,J. G.
Garcia,H. O.
Buhl,B.
Padilha,G. L.
Ethur,E. M.
Hoehne,L.
Bruno,A. N.
Freitas,E. M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues,K. F.
Bitencourt,T. C.
Núñez,J. G.
Garcia,H. O.
Buhl,B.
Padilha,G. L.
Ethur,E. M.
Hoehne,L.
Bruno,A. N.
Freitas,E. M.
dc.subject.por.fl_str_mv Bromelia Antiacantha
cervical câncer cells
phytochemical profile
SiHa lineage
HaCaT cells
topic Bromelia Antiacantha
cervical câncer cells
phytochemical profile
SiHa lineage
HaCaT cells
description Abstract Reports from popular medicine usually act as a basis for the development of new drugs from natural compounds with therapeutic actions for serious diseases and prevalence such as cancer. Bromelia antiacantha Bertol. is a species of the Bromeliaceae family, considered an unconventional food plant, found in the south and midwest regions of Brazil. Despite the high nutritional content and pharmacological potential of its fruits, few scientific studies report its biological actions. Thus, this study evaluates the phytochemical profile of aqueous and ethanol extracts obtained from B. antiacantha fruits, as well as their possible antioxidant, antitumor, and cytotoxic activities. The aqueous extract exhibited phenolic compounds and flavonoids, while ethanol extracts indicated the presence of flavonoids and coumarin in their composition, regardless of the region of collection. The ethanolic extract demonstrated a more promising antioxidant effect than the aqueous extract and also induced a significant inhibition in the viability of human cervical cancer cells of the SiHa strain. In addition, treatment with both extracts did not alter the viability of non-tumor cells of the immortalized human keratinocyte lineage (HaCaT). These results bring new data about extracts obtained from a native plant, edible and traditionally used in popular medicine, opening new perspectives for its possible therapeutic application.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100225
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100225
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1519-6984.255529
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Internacional de Ecologia
publisher.none.fl_str_mv Instituto Internacional de Ecologia
dc.source.none.fl_str_mv Brazilian Journal of Biology v.84 2024
reponame:Brazilian Journal of Biology
instname:Instituto Internacional de Ecologia (IIE)
instacron:IIE
instname_str Instituto Internacional de Ecologia (IIE)
instacron_str IIE
institution IIE
reponame_str Brazilian Journal of Biology
collection Brazilian Journal of Biology
repository.name.fl_str_mv Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)
repository.mail.fl_str_mv bjb@bjb.com.br||bjb@bjb.com.br
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