Phytochemical profile and biological activities of Bromelia antiacantha extracts
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100225 |
Resumo: | Abstract Reports from popular medicine usually act as a basis for the development of new drugs from natural compounds with therapeutic actions for serious diseases and prevalence such as cancer. Bromelia antiacantha Bertol. is a species of the Bromeliaceae family, considered an unconventional food plant, found in the south and midwest regions of Brazil. Despite the high nutritional content and pharmacological potential of its fruits, few scientific studies report its biological actions. Thus, this study evaluates the phytochemical profile of aqueous and ethanol extracts obtained from B. antiacantha fruits, as well as their possible antioxidant, antitumor, and cytotoxic activities. The aqueous extract exhibited phenolic compounds and flavonoids, while ethanol extracts indicated the presence of flavonoids and coumarin in their composition, regardless of the region of collection. The ethanolic extract demonstrated a more promising antioxidant effect than the aqueous extract and also induced a significant inhibition in the viability of human cervical cancer cells of the SiHa strain. In addition, treatment with both extracts did not alter the viability of non-tumor cells of the immortalized human keratinocyte lineage (HaCaT). These results bring new data about extracts obtained from a native plant, edible and traditionally used in popular medicine, opening new perspectives for its possible therapeutic application. |
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Phytochemical profile and biological activities of Bromelia antiacantha extractsBromelia Antiacanthacervical câncer cellsphytochemical profileSiHa lineageHaCaT cellsAbstract Reports from popular medicine usually act as a basis for the development of new drugs from natural compounds with therapeutic actions for serious diseases and prevalence such as cancer. Bromelia antiacantha Bertol. is a species of the Bromeliaceae family, considered an unconventional food plant, found in the south and midwest regions of Brazil. Despite the high nutritional content and pharmacological potential of its fruits, few scientific studies report its biological actions. Thus, this study evaluates the phytochemical profile of aqueous and ethanol extracts obtained from B. antiacantha fruits, as well as their possible antioxidant, antitumor, and cytotoxic activities. The aqueous extract exhibited phenolic compounds and flavonoids, while ethanol extracts indicated the presence of flavonoids and coumarin in their composition, regardless of the region of collection. The ethanolic extract demonstrated a more promising antioxidant effect than the aqueous extract and also induced a significant inhibition in the viability of human cervical cancer cells of the SiHa strain. In addition, treatment with both extracts did not alter the viability of non-tumor cells of the immortalized human keratinocyte lineage (HaCaT). These results bring new data about extracts obtained from a native plant, edible and traditionally used in popular medicine, opening new perspectives for its possible therapeutic application.Instituto Internacional de Ecologia2024-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100225Brazilian Journal of Biology v.84 2024reponame:Brazilian Journal of Biologyinstname:Instituto Internacional de Ecologia (IIE)instacron:IIE10.1590/1519-6984.255529info:eu-repo/semantics/openAccessRodrigues,K. F.Bitencourt,T. C.Núñez,J. G.Garcia,H. O.Buhl,B.Padilha,G. L.Ethur,E. M.Hoehne,L.Bruno,A. N.Freitas,E. M.eng2022-03-04T00:00:00Zoai:scielo:S1519-69842024000100225Revistahttps://www.scielo.br/j/bjb/https://old.scielo.br/oai/scielo-oai.phpbjb@bjb.com.br||bjb@bjb.com.br1678-43751519-6984opendoar:2022-03-04T00:00Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)false |
dc.title.none.fl_str_mv |
Phytochemical profile and biological activities of Bromelia antiacantha extracts |
title |
Phytochemical profile and biological activities of Bromelia antiacantha extracts |
spellingShingle |
Phytochemical profile and biological activities of Bromelia antiacantha extracts Rodrigues,K. F. Bromelia Antiacantha cervical câncer cells phytochemical profile SiHa lineage HaCaT cells |
title_short |
Phytochemical profile and biological activities of Bromelia antiacantha extracts |
title_full |
Phytochemical profile and biological activities of Bromelia antiacantha extracts |
title_fullStr |
Phytochemical profile and biological activities of Bromelia antiacantha extracts |
title_full_unstemmed |
Phytochemical profile and biological activities of Bromelia antiacantha extracts |
title_sort |
Phytochemical profile and biological activities of Bromelia antiacantha extracts |
author |
Rodrigues,K. F. |
author_facet |
Rodrigues,K. F. Bitencourt,T. C. Núñez,J. G. Garcia,H. O. Buhl,B. Padilha,G. L. Ethur,E. M. Hoehne,L. Bruno,A. N. Freitas,E. M. |
author_role |
author |
author2 |
Bitencourt,T. C. Núñez,J. G. Garcia,H. O. Buhl,B. Padilha,G. L. Ethur,E. M. Hoehne,L. Bruno,A. N. Freitas,E. M. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues,K. F. Bitencourt,T. C. Núñez,J. G. Garcia,H. O. Buhl,B. Padilha,G. L. Ethur,E. M. Hoehne,L. Bruno,A. N. Freitas,E. M. |
dc.subject.por.fl_str_mv |
Bromelia Antiacantha cervical câncer cells phytochemical profile SiHa lineage HaCaT cells |
topic |
Bromelia Antiacantha cervical câncer cells phytochemical profile SiHa lineage HaCaT cells |
description |
Abstract Reports from popular medicine usually act as a basis for the development of new drugs from natural compounds with therapeutic actions for serious diseases and prevalence such as cancer. Bromelia antiacantha Bertol. is a species of the Bromeliaceae family, considered an unconventional food plant, found in the south and midwest regions of Brazil. Despite the high nutritional content and pharmacological potential of its fruits, few scientific studies report its biological actions. Thus, this study evaluates the phytochemical profile of aqueous and ethanol extracts obtained from B. antiacantha fruits, as well as their possible antioxidant, antitumor, and cytotoxic activities. The aqueous extract exhibited phenolic compounds and flavonoids, while ethanol extracts indicated the presence of flavonoids and coumarin in their composition, regardless of the region of collection. The ethanolic extract demonstrated a more promising antioxidant effect than the aqueous extract and also induced a significant inhibition in the viability of human cervical cancer cells of the SiHa strain. In addition, treatment with both extracts did not alter the viability of non-tumor cells of the immortalized human keratinocyte lineage (HaCaT). These results bring new data about extracts obtained from a native plant, edible and traditionally used in popular medicine, opening new perspectives for its possible therapeutic application. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100225 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100225 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1519-6984.255529 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Internacional de Ecologia |
publisher.none.fl_str_mv |
Instituto Internacional de Ecologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Biology v.84 2024 reponame:Brazilian Journal of Biology instname:Instituto Internacional de Ecologia (IIE) instacron:IIE |
instname_str |
Instituto Internacional de Ecologia (IIE) |
instacron_str |
IIE |
institution |
IIE |
reponame_str |
Brazilian Journal of Biology |
collection |
Brazilian Journal of Biology |
repository.name.fl_str_mv |
Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE) |
repository.mail.fl_str_mv |
bjb@bjb.com.br||bjb@bjb.com.br |
_version_ |
1752129891157934080 |