Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC)
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842020000200266 |
Resumo: | Abstract The treatment of choice for chronic atrophic candidiasis (CAC), also known as denture stomatitis, is topical antifungal therapy. This study aimed to isolate, identify, and assess the antifungal susceptibility of Candida species from mucosal sites in denture wearers with a diagnosis of CAC and determine the prevalence of associated variables. The sample consisted of 44 patients wearing complete or partial dentures who had a clinical diagnosis of CAC. Using sterile cotton swabs, specimens were collected from the oral mucosa of all patients and grown at 30ºC for 48 h in CHROMagar Candida, as a means of isolating and screening the species. The complementary identification of the species was performed using the VITEK 2 automated system (BioMérieux), as well as the determination of their susceptibility to antifungal agents. Data were analyzed using the chi-square test. STATA 13.1 was used for statistical analysis (α = 5%). Of 44 patients with CAC, 33 (75%) had lesions classified as Newton type II. Yeasts were isolated in 38 cases. The most prevalent species was Candida albicans. None of the isolates were resistant to the antifungals tested. Our findings suggest that current indications for antifungal agents are appropriate. Also, antifungal susceptibility testing and proper fungal identification can help dentists to determine the optimal course of treatment for CAC. |
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Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC)Candidayeastsdenture stomatitisantifungalsusceptibilityAbstract The treatment of choice for chronic atrophic candidiasis (CAC), also known as denture stomatitis, is topical antifungal therapy. This study aimed to isolate, identify, and assess the antifungal susceptibility of Candida species from mucosal sites in denture wearers with a diagnosis of CAC and determine the prevalence of associated variables. The sample consisted of 44 patients wearing complete or partial dentures who had a clinical diagnosis of CAC. Using sterile cotton swabs, specimens were collected from the oral mucosa of all patients and grown at 30ºC for 48 h in CHROMagar Candida, as a means of isolating and screening the species. The complementary identification of the species was performed using the VITEK 2 automated system (BioMérieux), as well as the determination of their susceptibility to antifungal agents. Data were analyzed using the chi-square test. STATA 13.1 was used for statistical analysis (α = 5%). Of 44 patients with CAC, 33 (75%) had lesions classified as Newton type II. Yeasts were isolated in 38 cases. The most prevalent species was Candida albicans. None of the isolates were resistant to the antifungals tested. Our findings suggest that current indications for antifungal agents are appropriate. Also, antifungal susceptibility testing and proper fungal identification can help dentists to determine the optimal course of treatment for CAC.Instituto Internacional de Ecologia2020-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842020000200266Brazilian Journal of Biology v.80 n.2 2020reponame:Brazilian Journal of Biologyinstname:Instituto Internacional de Ecologia (IIE)instacron:IIE10.1590/1519-6984.190454info:eu-repo/semantics/openAccessReinhardt,L. C.Nascente,P. S.Ribeiro,J. S.Guimarães,V. B. S.Etges,A.Lund,R. G.eng2020-06-10T00:00:00Zoai:scielo:S1519-69842020000200266Revistahttps://www.scielo.br/j/bjb/https://old.scielo.br/oai/scielo-oai.phpbjb@bjb.com.br||bjb@bjb.com.br1678-43751519-6984opendoar:2020-06-10T00:00Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)false |
dc.title.none.fl_str_mv |
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC) |
title |
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC) |
spellingShingle |
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC) Reinhardt,L. C. Candida yeasts denture stomatitis antifungal susceptibility |
title_short |
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC) |
title_full |
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC) |
title_fullStr |
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC) |
title_full_unstemmed |
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC) |
title_sort |
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC) |
author |
Reinhardt,L. C. |
author_facet |
Reinhardt,L. C. Nascente,P. S. Ribeiro,J. S. Guimarães,V. B. S. Etges,A. Lund,R. G. |
author_role |
author |
author2 |
Nascente,P. S. Ribeiro,J. S. Guimarães,V. B. S. Etges,A. Lund,R. G. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Reinhardt,L. C. Nascente,P. S. Ribeiro,J. S. Guimarães,V. B. S. Etges,A. Lund,R. G. |
dc.subject.por.fl_str_mv |
Candida yeasts denture stomatitis antifungal susceptibility |
topic |
Candida yeasts denture stomatitis antifungal susceptibility |
description |
Abstract The treatment of choice for chronic atrophic candidiasis (CAC), also known as denture stomatitis, is topical antifungal therapy. This study aimed to isolate, identify, and assess the antifungal susceptibility of Candida species from mucosal sites in denture wearers with a diagnosis of CAC and determine the prevalence of associated variables. The sample consisted of 44 patients wearing complete or partial dentures who had a clinical diagnosis of CAC. Using sterile cotton swabs, specimens were collected from the oral mucosa of all patients and grown at 30ºC for 48 h in CHROMagar Candida, as a means of isolating and screening the species. The complementary identification of the species was performed using the VITEK 2 automated system (BioMérieux), as well as the determination of their susceptibility to antifungal agents. Data were analyzed using the chi-square test. STATA 13.1 was used for statistical analysis (α = 5%). Of 44 patients with CAC, 33 (75%) had lesions classified as Newton type II. Yeasts were isolated in 38 cases. The most prevalent species was Candida albicans. None of the isolates were resistant to the antifungals tested. Our findings suggest that current indications for antifungal agents are appropriate. Also, antifungal susceptibility testing and proper fungal identification can help dentists to determine the optimal course of treatment for CAC. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842020000200266 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842020000200266 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1519-6984.190454 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Internacional de Ecologia |
publisher.none.fl_str_mv |
Instituto Internacional de Ecologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Biology v.80 n.2 2020 reponame:Brazilian Journal of Biology instname:Instituto Internacional de Ecologia (IIE) instacron:IIE |
instname_str |
Instituto Internacional de Ecologia (IIE) |
instacron_str |
IIE |
institution |
IIE |
reponame_str |
Brazilian Journal of Biology |
collection |
Brazilian Journal of Biology |
repository.name.fl_str_mv |
Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE) |
repository.mail.fl_str_mv |
bjb@bjb.com.br||bjb@bjb.com.br |
_version_ |
1752129886666883072 |