Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review

Detalhes bibliográficos
Autor(a) principal: Santos,Carina de Sousa
Data de Publicação: 2019
Outros Autores: Nascimento,Fabrício Expedito Lopes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000300600
Resumo: ABSTRACT Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for muscle hypertrophy in humans is somewhat equivocal. This brief review describes physiological and biochemical mechanisms underpinning the effects of complete protein source and branched-chain amino acid intake on skeletal muscle growth in the postabsorptive and post-exercise state. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is also examined.
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spelling Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical reviewLeucineValineIsoleucineAmino acids, branched-chainHypertrophyMuscle, skeletalABSTRACT Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for muscle hypertrophy in humans is somewhat equivocal. This brief review describes physiological and biochemical mechanisms underpinning the effects of complete protein source and branched-chain amino acid intake on skeletal muscle growth in the postabsorptive and post-exercise state. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is also examined.Instituto Israelita de Ensino e Pesquisa Albert Einstein2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000300600einstein (São Paulo) v.17 n.3 2019reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2019rb4898info:eu-repo/semantics/openAccessSantos,Carina de SousaNascimento,Fabrício Expedito Lopeseng2019-09-02T00:00:00Zoai:scielo:S1679-45082019000300600Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2019-09-02T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
title Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
spellingShingle Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
Santos,Carina de Sousa
Leucine
Valine
Isoleucine
Amino acids, branched-chain
Hypertrophy
Muscle, skeletal
title_short Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
title_full Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
title_fullStr Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
title_full_unstemmed Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
title_sort Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
author Santos,Carina de Sousa
author_facet Santos,Carina de Sousa
Nascimento,Fabrício Expedito Lopes
author_role author
author2 Nascimento,Fabrício Expedito Lopes
author2_role author
dc.contributor.author.fl_str_mv Santos,Carina de Sousa
Nascimento,Fabrício Expedito Lopes
dc.subject.por.fl_str_mv Leucine
Valine
Isoleucine
Amino acids, branched-chain
Hypertrophy
Muscle, skeletal
topic Leucine
Valine
Isoleucine
Amino acids, branched-chain
Hypertrophy
Muscle, skeletal
description ABSTRACT Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for muscle hypertrophy in humans is somewhat equivocal. This brief review describes physiological and biochemical mechanisms underpinning the effects of complete protein source and branched-chain amino acid intake on skeletal muscle growth in the postabsorptive and post-exercise state. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is also examined.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000300600
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000300600
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.31744/einstein_journal/2019rb4898
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.17 n.3 2019
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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