Autologous stem-cell transplantation for multiple myeloma: a Brazilian institution experience in 15 years of follow-up

• Autor(a) principal: Todaro,Juliana
• Data de Publicação: 2011
• Outros Autores: Manhani,Ana Rita de Araújo Burgos, Kutner,José Mauro, Ribeiro,Andreza Alice Feitosa, Rodrigues,Morgani, Kerbauy,Fabio Rodrigues, Sobrinho,Jairo Nascimento, Ferreira,Eurípedes, Hamerschlak,Nelson
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Einstein (São Paulo)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200119
• topic: Multiple myeloma; Transplantation; autologous; Bone marrow transplantation; Survivorship (Publich Health)

Objective: To determine the 5-year post-transplant survival of patients with multiple myeloma. Methods: A retrospective study in patients diagnosed with multiple myeloma submitted to autologous bone marrow transplantation at a Brazilian institution, during the period of 1993 to 2007. Results: Seventy-three patients were evaluated with a median age of 55 years. Survival in 5 years was 75% (2.4 to 60 months). Statistical analysis demonstrated statistical significance for the applied grade of response prior to treatment with autologous bone marrow transplantation (p = 0.01). There was no statistical significance for clinical staging or time of diagnosis (before or after the year 2000). Conclusion: Experience in autologous bone marrow transplantation for multiple myeloma at a Brazilian institution demonstrated an evolution consistent with that of medical literature and highlighted the importance of a response to treatment prior to transplantation in the survival of these patients.