Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/19382 |
Resumo: | OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients. |
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Clinics |
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Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients MyelomaQuality of lifeSF-36QLQ-C30Transplantation OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1938210.1590/S1807-59322011001100002Clinics; Vol. 66 No. 11 (2011); 1855-1859 Clinics; v. 66 n. 11 (2011); 1855-1859 Clinics; Vol. 66 Núm. 11 (2011); 1855-1859 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19382/21445Etto, Leina YMorel, Vânia MarisSilva, Vanderleia CHungria, Vania T. MCiconelli, Rozana MAlmeida, Manuella S. SOliveira, José Salvador R. deBarros, José CarlosDurie, Brian GColleoni, Gisele W. Binfo:eu-repo/semantics/openAccess2012-05-23T16:37:20Zoai:revistas.usp.br:article/19382Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:37:20Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients |
title |
Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients |
spellingShingle |
Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients Etto, Leina Y Myeloma Quality of life SF-36 QLQ-C30 Transplantation |
title_short |
Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients |
title_full |
Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients |
title_fullStr |
Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients |
title_full_unstemmed |
Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients |
title_sort |
Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients |
author |
Etto, Leina Y |
author_facet |
Etto, Leina Y Morel, Vânia Maris Silva, Vanderleia C Hungria, Vania T. M Ciconelli, Rozana M Almeida, Manuella S. S Oliveira, José Salvador R. de Barros, José Carlos Durie, Brian G Colleoni, Gisele W. B |
author_role |
author |
author2 |
Morel, Vânia Maris Silva, Vanderleia C Hungria, Vania T. M Ciconelli, Rozana M Almeida, Manuella S. S Oliveira, José Salvador R. de Barros, José Carlos Durie, Brian G Colleoni, Gisele W. B |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Etto, Leina Y Morel, Vânia Maris Silva, Vanderleia C Hungria, Vania T. M Ciconelli, Rozana M Almeida, Manuella S. S Oliveira, José Salvador R. de Barros, José Carlos Durie, Brian G Colleoni, Gisele W. B |
dc.subject.por.fl_str_mv |
Myeloma Quality of life SF-36 QLQ-C30 Transplantation |
topic |
Myeloma Quality of life SF-36 QLQ-C30 Transplantation |
description |
OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19382 10.1590/S1807-59322011001100002 |
url |
https://www.revistas.usp.br/clinics/article/view/19382 |
identifier_str_mv |
10.1590/S1807-59322011001100002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19382/21445 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 66 No. 11 (2011); 1855-1859 Clinics; v. 66 n. 11 (2011); 1855-1859 Clinics; Vol. 66 Núm. 11 (2011); 1855-1859 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222756861640704 |