Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100263 |
Resumo: | ABSTRACT Objective To evaluate the therapeutic response to induction treatment in lupus nephritis patients. Methods A total of 29 patients diagnosed with systemic lupus erythematosus and biopsy-proven nephritis were divided into two groups, one with hypertensive individuals and another non-hypertensive patients. The hypertensive patients included were on drugs with antiproteinuric effect. The induction treatment comprised mycophenolate mofetil or cyclophosphamide, based on 24-hour proteinuria and serum creatinine parameters for therapeutic evaluation after 6 months of intervention. The retrospective evaluation of the follow-up was made based on information collected from the medical records. Results Patients with and without hypertension presented similar behaviors of proteinuria (p=0.127) and creatinine (p=0.514) over time. For proteinuria, only the time effect (p=0.007), but not hypertensive effect (p=0.232), was found. There was a reduction in proteinuria levels (reduction by 3.28g/24 hours, on average) from the beginning to the final measurement. As to creatinine, no hypertensive (p=0.757) or time (p=0.154) effects were found. Conclusion Similarity in behavior of proteinuria was observed, after induction treatment for nephritis, taking into account the hypertensive effect. The prior condition did not hinder these patients reaching the recommended proteinuria goal. |
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Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritisLupus nephritisProteinuriaRenal insufficiency, chronicHypertensionRenin-angiotensin systemABSTRACT Objective To evaluate the therapeutic response to induction treatment in lupus nephritis patients. Methods A total of 29 patients diagnosed with systemic lupus erythematosus and biopsy-proven nephritis were divided into two groups, one with hypertensive individuals and another non-hypertensive patients. The hypertensive patients included were on drugs with antiproteinuric effect. The induction treatment comprised mycophenolate mofetil or cyclophosphamide, based on 24-hour proteinuria and serum creatinine parameters for therapeutic evaluation after 6 months of intervention. The retrospective evaluation of the follow-up was made based on information collected from the medical records. Results Patients with and without hypertension presented similar behaviors of proteinuria (p=0.127) and creatinine (p=0.514) over time. For proteinuria, only the time effect (p=0.007), but not hypertensive effect (p=0.232), was found. There was a reduction in proteinuria levels (reduction by 3.28g/24 hours, on average) from the beginning to the final measurement. As to creatinine, no hypertensive (p=0.757) or time (p=0.154) effects were found. Conclusion Similarity in behavior of proteinuria was observed, after induction treatment for nephritis, taking into account the hypertensive effect. The prior condition did not hinder these patients reaching the recommended proteinuria goal.Instituto Israelita de Ensino e Pesquisa Albert Einstein2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100263einstein (São Paulo) v.18 2020reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2020ao5322info:eu-repo/semantics/openAccessMatta,Eduardo GreccoRubini,Danielle ArraesAraújo,Nafice Costaeng2020-10-05T00:00:00Zoai:scielo:S1679-45082020000100263Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2020-10-05T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis |
title |
Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis |
spellingShingle |
Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis Matta,Eduardo Grecco Lupus nephritis Proteinuria Renal insufficiency, chronic Hypertension Renin-angiotensin system |
title_short |
Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis |
title_full |
Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis |
title_fullStr |
Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis |
title_full_unstemmed |
Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis |
title_sort |
Effect of systemic arterial hypertension and use of antiproteinuric drug in induction therapy for lupus nephritis |
author |
Matta,Eduardo Grecco |
author_facet |
Matta,Eduardo Grecco Rubini,Danielle Arraes Araújo,Nafice Costa |
author_role |
author |
author2 |
Rubini,Danielle Arraes Araújo,Nafice Costa |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Matta,Eduardo Grecco Rubini,Danielle Arraes Araújo,Nafice Costa |
dc.subject.por.fl_str_mv |
Lupus nephritis Proteinuria Renal insufficiency, chronic Hypertension Renin-angiotensin system |
topic |
Lupus nephritis Proteinuria Renal insufficiency, chronic Hypertension Renin-angiotensin system |
description |
ABSTRACT Objective To evaluate the therapeutic response to induction treatment in lupus nephritis patients. Methods A total of 29 patients diagnosed with systemic lupus erythematosus and biopsy-proven nephritis were divided into two groups, one with hypertensive individuals and another non-hypertensive patients. The hypertensive patients included were on drugs with antiproteinuric effect. The induction treatment comprised mycophenolate mofetil or cyclophosphamide, based on 24-hour proteinuria and serum creatinine parameters for therapeutic evaluation after 6 months of intervention. The retrospective evaluation of the follow-up was made based on information collected from the medical records. Results Patients with and without hypertension presented similar behaviors of proteinuria (p=0.127) and creatinine (p=0.514) over time. For proteinuria, only the time effect (p=0.007), but not hypertensive effect (p=0.232), was found. There was a reduction in proteinuria levels (reduction by 3.28g/24 hours, on average) from the beginning to the final measurement. As to creatinine, no hypertensive (p=0.757) or time (p=0.154) effects were found. Conclusion Similarity in behavior of proteinuria was observed, after induction treatment for nephritis, taking into account the hypertensive effect. The prior condition did not hinder these patients reaching the recommended proteinuria goal. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100263 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100263 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.31744/einstein_journal/2020ao5322 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.18 2020 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
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Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129910131916800 |