Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100058 |
Resumo: | ABSTRACT Objective To investigate the frequency of anxiety and depression and their association with clinical features of amyotrophic lateral sclerosis. Methods This is a cross-sectional and descriptive study including a consecutive series of patients with sporadic amyotrophic lateral sclerosis according to Awaji’s criteria. Patients underwent clinical and psychiatric assessment (anxiety and depression symptoms). Results We included 76 patients. The men/women ratio was 1.6:1. Participants’ mean age at disease onset was 55 years (SD±12.1). Sixty-six patients (86.8%) were able to complete psychiatric evaluation. Clinically significant anxiety was found in 23 patients (34.8%) while clinically significant depression was found in 24 patients (36.4%). When we compared patients with and without depression a significant difference was seen only in the frequency of anxiety symptoms (p<0.001). We did further analysis comparing subgroups of patients classified according to the presence or not of anxiety and or depression, without any significant difference regarding sex, age at onset, initial form, disease duration or functional measures. A positive correlation between anxiety and depressive symptoms was found (p<0.001). Conclusion Anxiety and depressive symptoms were highly correlated and frequent in patients with amyotrophic lateral sclerosis. In addition, anxiety and depression were not associated with disease duration and presentation, sex, age at onset, and functional score. |
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Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical featuresAmyotrophic lateral sclerosis/diagnosisDepressionAnxietyABSTRACT Objective To investigate the frequency of anxiety and depression and their association with clinical features of amyotrophic lateral sclerosis. Methods This is a cross-sectional and descriptive study including a consecutive series of patients with sporadic amyotrophic lateral sclerosis according to Awaji’s criteria. Patients underwent clinical and psychiatric assessment (anxiety and depression symptoms). Results We included 76 patients. The men/women ratio was 1.6:1. Participants’ mean age at disease onset was 55 years (SD±12.1). Sixty-six patients (86.8%) were able to complete psychiatric evaluation. Clinically significant anxiety was found in 23 patients (34.8%) while clinically significant depression was found in 24 patients (36.4%). When we compared patients with and without depression a significant difference was seen only in the frequency of anxiety symptoms (p<0.001). We did further analysis comparing subgroups of patients classified according to the presence or not of anxiety and or depression, without any significant difference regarding sex, age at onset, initial form, disease duration or functional measures. A positive correlation between anxiety and depressive symptoms was found (p<0.001). Conclusion Anxiety and depressive symptoms were highly correlated and frequent in patients with amyotrophic lateral sclerosis. In addition, anxiety and depression were not associated with disease duration and presentation, sex, age at onset, and functional score.Instituto Israelita de Ensino e Pesquisa Albert Einstein2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100058einstein (São Paulo) v.15 n.1 2017reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082017ao3870info:eu-repo/semantics/openAccessPrado,Laura de Godoy RousseffBicalho,Isabella Carolina SantosVidigal-Lopes,MauroPrado,Vitor de Godoy RousseffGomez,Rodrigo SantiagoSouza,Leonardo Cruz deTeixeira,Antônio Lúcioeng2017-10-16T00:00:00Zoai:scielo:S1679-45082017000100058Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-10-16T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features |
title |
Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features |
spellingShingle |
Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features Prado,Laura de Godoy Rousseff Amyotrophic lateral sclerosis/diagnosis Depression Anxiety |
title_short |
Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features |
title_full |
Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features |
title_fullStr |
Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features |
title_full_unstemmed |
Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features |
title_sort |
Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features |
author |
Prado,Laura de Godoy Rousseff |
author_facet |
Prado,Laura de Godoy Rousseff Bicalho,Isabella Carolina Santos Vidigal-Lopes,Mauro Prado,Vitor de Godoy Rousseff Gomez,Rodrigo Santiago Souza,Leonardo Cruz de Teixeira,Antônio Lúcio |
author_role |
author |
author2 |
Bicalho,Isabella Carolina Santos Vidigal-Lopes,Mauro Prado,Vitor de Godoy Rousseff Gomez,Rodrigo Santiago Souza,Leonardo Cruz de Teixeira,Antônio Lúcio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Prado,Laura de Godoy Rousseff Bicalho,Isabella Carolina Santos Vidigal-Lopes,Mauro Prado,Vitor de Godoy Rousseff Gomez,Rodrigo Santiago Souza,Leonardo Cruz de Teixeira,Antônio Lúcio |
dc.subject.por.fl_str_mv |
Amyotrophic lateral sclerosis/diagnosis Depression Anxiety |
topic |
Amyotrophic lateral sclerosis/diagnosis Depression Anxiety |
description |
ABSTRACT Objective To investigate the frequency of anxiety and depression and their association with clinical features of amyotrophic lateral sclerosis. Methods This is a cross-sectional and descriptive study including a consecutive series of patients with sporadic amyotrophic lateral sclerosis according to Awaji’s criteria. Patients underwent clinical and psychiatric assessment (anxiety and depression symptoms). Results We included 76 patients. The men/women ratio was 1.6:1. Participants’ mean age at disease onset was 55 years (SD±12.1). Sixty-six patients (86.8%) were able to complete psychiatric evaluation. Clinically significant anxiety was found in 23 patients (34.8%) while clinically significant depression was found in 24 patients (36.4%). When we compared patients with and without depression a significant difference was seen only in the frequency of anxiety symptoms (p<0.001). We did further analysis comparing subgroups of patients classified according to the presence or not of anxiety and or depression, without any significant difference regarding sex, age at onset, initial form, disease duration or functional measures. A positive correlation between anxiety and depressive symptoms was found (p<0.001). Conclusion Anxiety and depressive symptoms were highly correlated and frequent in patients with amyotrophic lateral sclerosis. In addition, anxiety and depression were not associated with disease duration and presentation, sex, age at onset, and functional score. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100058 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100058 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1679-45082017ao3870 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.15 n.1 2017 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129908744650752 |