A review of alternative methods to the use of animals in safety evaluation of cosmetics
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100600 |
Resumo: | ABSTRACT Alternative methods to the use of animals in research have been a global trend, mainly after the publication of the 3R’s principle (Replacement, Reduction, and Refinement), proposed by Russel and Burch. In the cosmetic sector, safety and efficacy assessments using animals have generated controversial debates. For this reason, in vitro research techniques are widely used to assess acute toxicity; corrosivity and irritation; skin sensitization; dermal and percutaneous absorption; repeated dose toxicity; reproductive toxicity; mutagenicity and genotoxicity; carcinogenicity; toxicokinetic studies; photo-induced toxicity; and human data. Although there are many methodologies described, validated, and widely used in the cosmetic area, the evaluation of the safety of cosmetic ingredients and products is still an expanding field. It needs global collaboration among regulatory agencies, universities, and industry, to meet several unmet needs in the fields of sensitization, carcinogenicity, systemic action, among other issues involving safety of users of cosmetic products. This review article will cover the currently most relevant in vitro models regarding irritation, corrosion, sensitization, mutagenicity, genotoxicity, and phototoxicity, to help to choose the most appropriate test for evaluating the safety and toxicity of cosmetic ingredients and products. |
id |
IIEPAE-1_edec85b62b98940b71df6ed7b41350ed |
---|---|
oai_identifier_str |
oai:scielo:S1679-45082022000100600 |
network_acronym_str |
IIEPAE-1 |
network_name_str |
Einstein (São Paulo) |
repository_id_str |
|
spelling |
A review of alternative methods to the use of animals in safety evaluation of cosmeticsAlternative methodsToxicityIn vitro techniquesCosmeticsSafety assessmentAnimalsABSTRACT Alternative methods to the use of animals in research have been a global trend, mainly after the publication of the 3R’s principle (Replacement, Reduction, and Refinement), proposed by Russel and Burch. In the cosmetic sector, safety and efficacy assessments using animals have generated controversial debates. For this reason, in vitro research techniques are widely used to assess acute toxicity; corrosivity and irritation; skin sensitization; dermal and percutaneous absorption; repeated dose toxicity; reproductive toxicity; mutagenicity and genotoxicity; carcinogenicity; toxicokinetic studies; photo-induced toxicity; and human data. Although there are many methodologies described, validated, and widely used in the cosmetic area, the evaluation of the safety of cosmetic ingredients and products is still an expanding field. It needs global collaboration among regulatory agencies, universities, and industry, to meet several unmet needs in the fields of sensitization, carcinogenicity, systemic action, among other issues involving safety of users of cosmetic products. This review article will cover the currently most relevant in vitro models regarding irritation, corrosion, sensitization, mutagenicity, genotoxicity, and phototoxicity, to help to choose the most appropriate test for evaluating the safety and toxicity of cosmetic ingredients and products.Instituto Israelita de Ensino e Pesquisa Albert Einstein2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100600einstein (São Paulo) v.20 2022reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2022rb5578info:eu-repo/semantics/openAccessNabarretti,Barbarah HelenaRigon,Roberta BalansinBurga-Sánchez,JonnyLeonardi,Gislaine Riccieng2022-02-04T00:00:00Zoai:scielo:S1679-45082022000100600Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2022-02-04T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
A review of alternative methods to the use of animals in safety evaluation of cosmetics |
title |
A review of alternative methods to the use of animals in safety evaluation of cosmetics |
spellingShingle |
A review of alternative methods to the use of animals in safety evaluation of cosmetics Nabarretti,Barbarah Helena Alternative methods Toxicity In vitro techniques Cosmetics Safety assessment Animals |
title_short |
A review of alternative methods to the use of animals in safety evaluation of cosmetics |
title_full |
A review of alternative methods to the use of animals in safety evaluation of cosmetics |
title_fullStr |
A review of alternative methods to the use of animals in safety evaluation of cosmetics |
title_full_unstemmed |
A review of alternative methods to the use of animals in safety evaluation of cosmetics |
title_sort |
A review of alternative methods to the use of animals in safety evaluation of cosmetics |
author |
Nabarretti,Barbarah Helena |
author_facet |
Nabarretti,Barbarah Helena Rigon,Roberta Balansin Burga-Sánchez,Jonny Leonardi,Gislaine Ricci |
author_role |
author |
author2 |
Rigon,Roberta Balansin Burga-Sánchez,Jonny Leonardi,Gislaine Ricci |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Nabarretti,Barbarah Helena Rigon,Roberta Balansin Burga-Sánchez,Jonny Leonardi,Gislaine Ricci |
dc.subject.por.fl_str_mv |
Alternative methods Toxicity In vitro techniques Cosmetics Safety assessment Animals |
topic |
Alternative methods Toxicity In vitro techniques Cosmetics Safety assessment Animals |
description |
ABSTRACT Alternative methods to the use of animals in research have been a global trend, mainly after the publication of the 3R’s principle (Replacement, Reduction, and Refinement), proposed by Russel and Burch. In the cosmetic sector, safety and efficacy assessments using animals have generated controversial debates. For this reason, in vitro research techniques are widely used to assess acute toxicity; corrosivity and irritation; skin sensitization; dermal and percutaneous absorption; repeated dose toxicity; reproductive toxicity; mutagenicity and genotoxicity; carcinogenicity; toxicokinetic studies; photo-induced toxicity; and human data. Although there are many methodologies described, validated, and widely used in the cosmetic area, the evaluation of the safety of cosmetic ingredients and products is still an expanding field. It needs global collaboration among regulatory agencies, universities, and industry, to meet several unmet needs in the fields of sensitization, carcinogenicity, systemic action, among other issues involving safety of users of cosmetic products. This review article will cover the currently most relevant in vitro models regarding irritation, corrosion, sensitization, mutagenicity, genotoxicity, and phototoxicity, to help to choose the most appropriate test for evaluating the safety and toxicity of cosmetic ingredients and products. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100600 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100600 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.31744/einstein_journal/2022rb5578 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.20 2022 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
_version_ |
1752129911327293440 |