Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients

Detalhes bibliográficos
Autor(a) principal: Palomba,Henrique
Data de Publicação: 2015
Outros Autores: Corrêa,Thiago Domingos, Silva,Eliézer, Pardini,Andreia, Assuncao,Murillo Santucci Cesar de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000300357
Resumo: Objective To compare outcomes between elderly (≥65 years old) and non-elderly (<65 years old) resuscitated severe sepsis and septic shock patients and determine predictors of death among elderly patients.Methods Retrospective cohort study including 848 severe sepsis and septic shock patients admitted to the intensive care unit between January 2006 and March 2012.Results Elderly patients accounted for 62.6% (531/848) and non-elderly patients for 37.4% (317/848). Elderly patients had a higher APACHE II score [22 (18-28)versus 19 (15-24); p<0.001], compared to non-elderly patients, although the number of organ dysfunctions did not differ between the groups. No significant differences were found in 28-day and in-hospital mortality rates between elderly and non-elderly patients. The length of hospital stay was higher in elderly compared to non-elderly patients admitted with severe sepsis and septic shock [18 (10-41)versus 14 (8-29) days, respectively; p=0.0001]. Predictors of death among elderly patients included age, site of diagnosis, APACHE II score, need for mechanical ventilation and vasopressors.Conclusion In this study population early resuscitation of elderly patients was not associated with increased in-hospital mortality. Prospective studies addressing the long-term impact on functional status and quality of life are necessary.
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spelling Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patientsAgedSepsisShock, septicShockResuscitationMultiple organ failureFluid therapyVasoconstrictor agentsObjective To compare outcomes between elderly (≥65 years old) and non-elderly (<65 years old) resuscitated severe sepsis and septic shock patients and determine predictors of death among elderly patients.Methods Retrospective cohort study including 848 severe sepsis and septic shock patients admitted to the intensive care unit between January 2006 and March 2012.Results Elderly patients accounted for 62.6% (531/848) and non-elderly patients for 37.4% (317/848). Elderly patients had a higher APACHE II score [22 (18-28)versus 19 (15-24); p<0.001], compared to non-elderly patients, although the number of organ dysfunctions did not differ between the groups. No significant differences were found in 28-day and in-hospital mortality rates between elderly and non-elderly patients. The length of hospital stay was higher in elderly compared to non-elderly patients admitted with severe sepsis and septic shock [18 (10-41)versus 14 (8-29) days, respectively; p=0.0001]. Predictors of death among elderly patients included age, site of diagnosis, APACHE II score, need for mechanical ventilation and vasopressors.Conclusion In this study population early resuscitation of elderly patients was not associated with increased in-hospital mortality. Prospective studies addressing the long-term impact on functional status and quality of life are necessary.Instituto Israelita de Ensino e Pesquisa Albert Einstein2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000300357einstein (São Paulo) v.13 n.3 2015reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/S1679-45082015AO3313info:eu-repo/semantics/openAccessPalomba,HenriqueCorrêa,Thiago DomingosSilva,EliézerPardini,AndreiaAssuncao,Murillo Santucci Cesar deeng2015-10-13T00:00:00Zoai:scielo:S1679-45082015000300357Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2015-10-13T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
title Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
spellingShingle Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
Palomba,Henrique
Aged
Sepsis
Shock, septic
Shock
Resuscitation
Multiple organ failure
Fluid therapy
Vasoconstrictor agents
title_short Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
title_full Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
title_fullStr Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
title_full_unstemmed Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
title_sort Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
author Palomba,Henrique
author_facet Palomba,Henrique
Corrêa,Thiago Domingos
Silva,Eliézer
Pardini,Andreia
Assuncao,Murillo Santucci Cesar de
author_role author
author2 Corrêa,Thiago Domingos
Silva,Eliézer
Pardini,Andreia
Assuncao,Murillo Santucci Cesar de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Palomba,Henrique
Corrêa,Thiago Domingos
Silva,Eliézer
Pardini,Andreia
Assuncao,Murillo Santucci Cesar de
dc.subject.por.fl_str_mv Aged
Sepsis
Shock, septic
Shock
Resuscitation
Multiple organ failure
Fluid therapy
Vasoconstrictor agents
topic Aged
Sepsis
Shock, septic
Shock
Resuscitation
Multiple organ failure
Fluid therapy
Vasoconstrictor agents
description Objective To compare outcomes between elderly (≥65 years old) and non-elderly (<65 years old) resuscitated severe sepsis and septic shock patients and determine predictors of death among elderly patients.Methods Retrospective cohort study including 848 severe sepsis and septic shock patients admitted to the intensive care unit between January 2006 and March 2012.Results Elderly patients accounted for 62.6% (531/848) and non-elderly patients for 37.4% (317/848). Elderly patients had a higher APACHE II score [22 (18-28)versus 19 (15-24); p<0.001], compared to non-elderly patients, although the number of organ dysfunctions did not differ between the groups. No significant differences were found in 28-day and in-hospital mortality rates between elderly and non-elderly patients. The length of hospital stay was higher in elderly compared to non-elderly patients admitted with severe sepsis and septic shock [18 (10-41)versus 14 (8-29) days, respectively; p=0.0001]. Predictors of death among elderly patients included age, site of diagnosis, APACHE II score, need for mechanical ventilation and vasopressors.Conclusion In this study population early resuscitation of elderly patients was not associated with increased in-hospital mortality. Prospective studies addressing the long-term impact on functional status and quality of life are necessary.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000300357
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000300357
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1679-45082015AO3313
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.13 n.3 2015
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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