Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000300357 |
Resumo: | Objective To compare outcomes between elderly (≥65 years old) and non-elderly (<65 years old) resuscitated severe sepsis and septic shock patients and determine predictors of death among elderly patients.Methods Retrospective cohort study including 848 severe sepsis and septic shock patients admitted to the intensive care unit between January 2006 and March 2012.Results Elderly patients accounted for 62.6% (531/848) and non-elderly patients for 37.4% (317/848). Elderly patients had a higher APACHE II score [22 (18-28)versus 19 (15-24); p<0.001], compared to non-elderly patients, although the number of organ dysfunctions did not differ between the groups. No significant differences were found in 28-day and in-hospital mortality rates between elderly and non-elderly patients. The length of hospital stay was higher in elderly compared to non-elderly patients admitted with severe sepsis and septic shock [18 (10-41)versus 14 (8-29) days, respectively; p=0.0001]. Predictors of death among elderly patients included age, site of diagnosis, APACHE II score, need for mechanical ventilation and vasopressors.Conclusion In this study population early resuscitation of elderly patients was not associated with increased in-hospital mortality. Prospective studies addressing the long-term impact on functional status and quality of life are necessary. |
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Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patientsAgedSepsisShock, septicShockResuscitationMultiple organ failureFluid therapyVasoconstrictor agentsObjective To compare outcomes between elderly (≥65 years old) and non-elderly (<65 years old) resuscitated severe sepsis and septic shock patients and determine predictors of death among elderly patients.Methods Retrospective cohort study including 848 severe sepsis and septic shock patients admitted to the intensive care unit between January 2006 and March 2012.Results Elderly patients accounted for 62.6% (531/848) and non-elderly patients for 37.4% (317/848). Elderly patients had a higher APACHE II score [22 (18-28)versus 19 (15-24); p<0.001], compared to non-elderly patients, although the number of organ dysfunctions did not differ between the groups. No significant differences were found in 28-day and in-hospital mortality rates between elderly and non-elderly patients. The length of hospital stay was higher in elderly compared to non-elderly patients admitted with severe sepsis and septic shock [18 (10-41)versus 14 (8-29) days, respectively; p=0.0001]. Predictors of death among elderly patients included age, site of diagnosis, APACHE II score, need for mechanical ventilation and vasopressors.Conclusion In this study population early resuscitation of elderly patients was not associated with increased in-hospital mortality. Prospective studies addressing the long-term impact on functional status and quality of life are necessary.Instituto Israelita de Ensino e Pesquisa Albert Einstein2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000300357einstein (São Paulo) v.13 n.3 2015reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/S1679-45082015AO3313info:eu-repo/semantics/openAccessPalomba,HenriqueCorrêa,Thiago DomingosSilva,EliézerPardini,AndreiaAssuncao,Murillo Santucci Cesar deeng2015-10-13T00:00:00Zoai:scielo:S1679-45082015000300357Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2015-10-13T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients |
title |
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients |
spellingShingle |
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients Palomba,Henrique Aged Sepsis Shock, septic Shock Resuscitation Multiple organ failure Fluid therapy Vasoconstrictor agents |
title_short |
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients |
title_full |
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients |
title_fullStr |
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients |
title_full_unstemmed |
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients |
title_sort |
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients |
author |
Palomba,Henrique |
author_facet |
Palomba,Henrique Corrêa,Thiago Domingos Silva,Eliézer Pardini,Andreia Assuncao,Murillo Santucci Cesar de |
author_role |
author |
author2 |
Corrêa,Thiago Domingos Silva,Eliézer Pardini,Andreia Assuncao,Murillo Santucci Cesar de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Palomba,Henrique Corrêa,Thiago Domingos Silva,Eliézer Pardini,Andreia Assuncao,Murillo Santucci Cesar de |
dc.subject.por.fl_str_mv |
Aged Sepsis Shock, septic Shock Resuscitation Multiple organ failure Fluid therapy Vasoconstrictor agents |
topic |
Aged Sepsis Shock, septic Shock Resuscitation Multiple organ failure Fluid therapy Vasoconstrictor agents |
description |
Objective To compare outcomes between elderly (≥65 years old) and non-elderly (<65 years old) resuscitated severe sepsis and septic shock patients and determine predictors of death among elderly patients.Methods Retrospective cohort study including 848 severe sepsis and septic shock patients admitted to the intensive care unit between January 2006 and March 2012.Results Elderly patients accounted for 62.6% (531/848) and non-elderly patients for 37.4% (317/848). Elderly patients had a higher APACHE II score [22 (18-28)versus 19 (15-24); p<0.001], compared to non-elderly patients, although the number of organ dysfunctions did not differ between the groups. No significant differences were found in 28-day and in-hospital mortality rates between elderly and non-elderly patients. The length of hospital stay was higher in elderly compared to non-elderly patients admitted with severe sepsis and septic shock [18 (10-41)versus 14 (8-29) days, respectively; p=0.0001]. Predictors of death among elderly patients included age, site of diagnosis, APACHE II score, need for mechanical ventilation and vasopressors.Conclusion In this study population early resuscitation of elderly patients was not associated with increased in-hospital mortality. Prospective studies addressing the long-term impact on functional status and quality of life are necessary. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000300357 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000300357 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1679-45082015AO3313 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.13 n.3 2015 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
_version_ |
1752129908324171776 |