Inflammatory biomarkers in sera of patients with intervertebral disc degeneration

Detalhes bibliográficos
Autor(a) principal: Rodrigues,Luciano Miller Reis
Data de Publicação: 2019
Outros Autores: Oliveira,Lilian Zerbinatti de, Silva,Mariane de Barros Ribeiro da, Accardo,Camila de Melo, Giglio,Adriana Braz Del, Pinhal,Maria Aparecida da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000400208
Resumo: ABSTRACT Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers. Methods: We conducted immunohistochemistry studies of intervertebral discs to analyze interleukin 6 and cathepsin B levels of patients with degenerative disease and spine fracture (Control Group) and to measure hyaluronic acid, interleukin 6 and cathepsin B activity from sera of intervertebral disc degeneration patients, fracture patients, and healthy individuals. Results: Interleukin 6 and cathepsin B seem to be related with physiopathology of intervertebral disc degeneration, since the levels of both were higher in discs of patients with intervertebral disc degeneration. Interleukin 6 and cathepsin B do not represent good biomarkers of degenerative intervertebral disc disease, since the level of such compounds is increased in the plasma of patients with fractures. Conclusion: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.
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spelling Inflammatory biomarkers in sera of patients with intervertebral disc degenerationBiomarkersProteoglycansGlycosaminoglycansIntervertebral disc degenerationABSTRACT Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers. Methods: We conducted immunohistochemistry studies of intervertebral discs to analyze interleukin 6 and cathepsin B levels of patients with degenerative disease and spine fracture (Control Group) and to measure hyaluronic acid, interleukin 6 and cathepsin B activity from sera of intervertebral disc degeneration patients, fracture patients, and healthy individuals. Results: Interleukin 6 and cathepsin B seem to be related with physiopathology of intervertebral disc degeneration, since the levels of both were higher in discs of patients with intervertebral disc degeneration. Interleukin 6 and cathepsin B do not represent good biomarkers of degenerative intervertebral disc disease, since the level of such compounds is increased in the plasma of patients with fractures. Conclusion: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.Instituto Israelita de Ensino e Pesquisa Albert Einstein2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000400208einstein (São Paulo) v.17 n.4 2019reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2019ao4637info:eu-repo/semantics/openAccessRodrigues,Luciano Miller ReisOliveira,Lilian Zerbinatti deSilva,Mariane de Barros Ribeiro daAccardo,Camila de MeloGiglio,Adriana Braz DelPinhal,Maria Aparecida da Silvaeng2019-08-27T00:00:00Zoai:scielo:S1679-45082019000400208Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2019-08-27T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Inflammatory biomarkers in sera of patients with intervertebral disc degeneration
title Inflammatory biomarkers in sera of patients with intervertebral disc degeneration
spellingShingle Inflammatory biomarkers in sera of patients with intervertebral disc degeneration
Rodrigues,Luciano Miller Reis
Biomarkers
Proteoglycans
Glycosaminoglycans
Intervertebral disc degeneration
title_short Inflammatory biomarkers in sera of patients with intervertebral disc degeneration
title_full Inflammatory biomarkers in sera of patients with intervertebral disc degeneration
title_fullStr Inflammatory biomarkers in sera of patients with intervertebral disc degeneration
title_full_unstemmed Inflammatory biomarkers in sera of patients with intervertebral disc degeneration
title_sort Inflammatory biomarkers in sera of patients with intervertebral disc degeneration
author Rodrigues,Luciano Miller Reis
author_facet Rodrigues,Luciano Miller Reis
Oliveira,Lilian Zerbinatti de
Silva,Mariane de Barros Ribeiro da
Accardo,Camila de Melo
Giglio,Adriana Braz Del
Pinhal,Maria Aparecida da Silva
author_role author
author2 Oliveira,Lilian Zerbinatti de
Silva,Mariane de Barros Ribeiro da
Accardo,Camila de Melo
Giglio,Adriana Braz Del
Pinhal,Maria Aparecida da Silva
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues,Luciano Miller Reis
Oliveira,Lilian Zerbinatti de
Silva,Mariane de Barros Ribeiro da
Accardo,Camila de Melo
Giglio,Adriana Braz Del
Pinhal,Maria Aparecida da Silva
dc.subject.por.fl_str_mv Biomarkers
Proteoglycans
Glycosaminoglycans
Intervertebral disc degeneration
topic Biomarkers
Proteoglycans
Glycosaminoglycans
Intervertebral disc degeneration
description ABSTRACT Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers. Methods: We conducted immunohistochemistry studies of intervertebral discs to analyze interleukin 6 and cathepsin B levels of patients with degenerative disease and spine fracture (Control Group) and to measure hyaluronic acid, interleukin 6 and cathepsin B activity from sera of intervertebral disc degeneration patients, fracture patients, and healthy individuals. Results: Interleukin 6 and cathepsin B seem to be related with physiopathology of intervertebral disc degeneration, since the levels of both were higher in discs of patients with intervertebral disc degeneration. Interleukin 6 and cathepsin B do not represent good biomarkers of degenerative intervertebral disc disease, since the level of such compounds is increased in the plasma of patients with fractures. Conclusion: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000400208
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000400208
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.31744/einstein_journal/2019ao4637
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.17 n.4 2019
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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