Study of nuclear volume of testicular cells in rats after the use of ofloxacin

Detalhes bibliográficos
Autor(a) principal: Paschoal, Vânia Del' Arco
Data de Publicação: 2005
Outros Autores: Rossit, Andréa Batista, Bizutti, Luiz O., Azoubel, Reinaldo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Hansenologia Internationalis (Online)
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35487
Resumo: Ofloxacin presents an ample spectrum of antimicrobial actión, including combating Mycobacterium leprae, and is currently employed as a substituta when the use of rifampicin is impossible. The objective of the present work was to study alterations in the nuclei of testicular cells in pubescent rats submitted to oral application of ofloxacin, and respective control groups. The method utilized was morphometry by the cariometric technique. The principie structures observed in histological preparations of the testicles were Leydig cells, spermatogonias, and Sertoli cells. 09 Wistar rats were utilized, five treated and four contrais, who received 12 mg of ofloxacin per Kg of body weight, from the ST* to 48th day after birth. On the 49th daythe rats were killed. The cariometric study of the Leydig cells, spermatogonias and Sertoli cells revealed that there were no significant changes in the forms of their nuclei (p > 0.05), permitting the conclusion that, at the doses used, the testicular cells suffered no alterations.
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spelling Study of nuclear volume of testicular cells in rats after the use of ofloxacinVolume dos núcleos das células do testículo de ratos sob efeitos da ofloxacinahanseníaseestículosratosofloxacinavolume nuclearcariometrialeprosytesticular cellscariometricnuclear volumeofloxacinOfloxacin presents an ample spectrum of antimicrobial actión, including combating Mycobacterium leprae, and is currently employed as a substituta when the use of rifampicin is impossible. The objective of the present work was to study alterations in the nuclei of testicular cells in pubescent rats submitted to oral application of ofloxacin, and respective control groups. The method utilized was morphometry by the cariometric technique. The principie structures observed in histological preparations of the testicles were Leydig cells, spermatogonias, and Sertoli cells. 09 Wistar rats were utilized, five treated and four contrais, who received 12 mg of ofloxacin per Kg of body weight, from the ST* to 48th day after birth. On the 49th daythe rats were killed. The cariometric study of the Leydig cells, spermatogonias and Sertoli cells revealed that there were no significant changes in the forms of their nuclei (p > 0.05), permitting the conclusion that, at the doses used, the testicular cells suffered no alterations.A ofloxacina possui amplo espectro de ação antimicrobiana, inclusive no combate ao Mycobacterium leprae, sendo atualmente empregada em substituição, quando da impossibilidade do uso da rifampicina. O objetivo deste foi estudar alterações nos núcleos das células do testículo de ratos púberes e respectivos grupos controle, submetidos à aplicação oral de ofloxacina. 0 método utilizado foi a morfometria, pela técnica cariométrica. As principais estruturas observadas nas preparações histológicas dos testículos foram: as células de Leydig, as espermatogônias e as células de Sertoli. Foram utilizados 09 ratos (Wistar), cinco tratados e quatro controles, aos quais foram administrados diariamente 12 mg/Kg/peso de ofloxacina, do 34Q ao 48Q dia após o nascimento. No 49a dia de vida, os ratos foram sacrificados. O estudo cariométrico das células de Leydig, das espermatogônias e das células de Sertoli de testículos dos animais tratados não evidenciou mudanças significativas na forma de seus núcleos (p > 0,05), quando comparados aos controles. Conclui-se que a oflocaxina na dose e período empregados não promoveu alterações nos constituintes celulares de testículos de ratos púberes.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2005-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3548710.47878/hi.2005.v30.35487Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 30 No. 1 (2005): 10º Congresso Brasileiro de Hansenologia - Sociedade Brasileira de Hansenologia - 19 a 22 de novembro de 2005 - Recife - Pernambuco -Brasil; 3-8Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 30 n. 1 (2005): 10º Congresso Brasileiro de Hansenologia - Sociedade Brasileira de Hansenologia - 19 a 22 de novembro de 2005 - Recife - Pernambuco -Brasil; 3-81982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35487/33906Paschoal, Vânia Del' ArcoRossit, Andréa BatistaBizutti, Luiz O.Azoubel, Reinaldoinfo:eu-repo/semantics/openAccess2022-02-17T21:01:37Zoai:ojs.periodicos.saude.sp.gov.br:article/35487Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2022-02-17T21:01:37Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Study of nuclear volume of testicular cells in rats after the use of ofloxacin
Volume dos núcleos das células do testículo de ratos sob efeitos da ofloxacina
title Study of nuclear volume of testicular cells in rats after the use of ofloxacin
spellingShingle Study of nuclear volume of testicular cells in rats after the use of ofloxacin
Paschoal, Vânia Del' Arco
hanseníase
estículos
ratos
ofloxacina
volume nuclear
cariometria
leprosy
testicular cells
cariometric
nuclear volume
ofloxacin
title_short Study of nuclear volume of testicular cells in rats after the use of ofloxacin
title_full Study of nuclear volume of testicular cells in rats after the use of ofloxacin
title_fullStr Study of nuclear volume of testicular cells in rats after the use of ofloxacin
title_full_unstemmed Study of nuclear volume of testicular cells in rats after the use of ofloxacin
title_sort Study of nuclear volume of testicular cells in rats after the use of ofloxacin
author Paschoal, Vânia Del' Arco
author_facet Paschoal, Vânia Del' Arco
Rossit, Andréa Batista
Bizutti, Luiz O.
Azoubel, Reinaldo
author_role author
author2 Rossit, Andréa Batista
Bizutti, Luiz O.
Azoubel, Reinaldo
author2_role author
author
author
dc.contributor.author.fl_str_mv Paschoal, Vânia Del' Arco
Rossit, Andréa Batista
Bizutti, Luiz O.
Azoubel, Reinaldo
dc.subject.por.fl_str_mv hanseníase
estículos
ratos
ofloxacina
volume nuclear
cariometria
leprosy
testicular cells
cariometric
nuclear volume
ofloxacin
topic hanseníase
estículos
ratos
ofloxacina
volume nuclear
cariometria
leprosy
testicular cells
cariometric
nuclear volume
ofloxacin
description Ofloxacin presents an ample spectrum of antimicrobial actión, including combating Mycobacterium leprae, and is currently employed as a substituta when the use of rifampicin is impossible. The objective of the present work was to study alterations in the nuclei of testicular cells in pubescent rats submitted to oral application of ofloxacin, and respective control groups. The method utilized was morphometry by the cariometric technique. The principie structures observed in histological preparations of the testicles were Leydig cells, spermatogonias, and Sertoli cells. 09 Wistar rats were utilized, five treated and four contrais, who received 12 mg of ofloxacin per Kg of body weight, from the ST* to 48th day after birth. On the 49th daythe rats were killed. The cariometric study of the Leydig cells, spermatogonias and Sertoli cells revealed that there were no significant changes in the forms of their nuclei (p > 0.05), permitting the conclusion that, at the doses used, the testicular cells suffered no alterations.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35487
10.47878/hi.2005.v30.35487
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/35487
identifier_str_mv 10.47878/hi.2005.v30.35487
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35487/33906
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 30 No. 1 (2005): 10º Congresso Brasileiro de Hansenologia - Sociedade Brasileira de Hansenologia - 19 a 22 de novembro de 2005 - Recife - Pernambuco -Brasil; 3-8
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 30 n. 1 (2005): 10º Congresso Brasileiro de Hansenologia - Sociedade Brasileira de Hansenologia - 19 a 22 de novembro de 2005 - Recife - Pernambuco -Brasil; 3-8
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
_version_ 1796797579690770432

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