Human genetic in leprosy susceptibility

Detalhes bibliográficos
Autor(a) principal: Souza, Vânia Nieto Brito de
Data de Publicação: 2007
Outros Autores: Pereira, Ana Carla
Tipo de documento: Artigo
Idioma: por
Título da fonte: Hansenologia Internationalis (Online)
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199
Resumo: Data from familiar investigations, studies involving twins and from Mycobacterium leprae genomic, as well epidemiological observations of leprosy have shown the importance of the human genetic as determinant of the disease’s course, from the resistance, to the immunological dichotomy which defines tuberculoid and lepromatous poles. Thus, studies using genome-wide scan and association methods have shown some genomic regions whose alterations are candidates to risk factors for leprosy. However, these associations are weak and are not repeated in all different studies, which put in evidence the divergence in risk factors for different populations as well in design studies as causatives of this controversial data. In this manner, this review has as purpose the data collection which have already been described about human genomic regions that must participate in the genetic control of leprosy
id ILSL-1_8ca6902911ba8481297637a5fca998a9
oai_identifier_str oai:ojs.periodicos.saude.sp.gov.br:article/35199
network_acronym_str ILSL-1
network_name_str Hansenologia Internationalis (Online)
repository_id_str
spelling Human genetic in leprosy susceptibilityGenética humana na susceptibilidade à hanseníasehanseníasepolimorfismo de um único nucleotídeosusceptibilidade genéticaleprosysingle nucleotide polymorphismgenetic susceptibilityData from familiar investigations, studies involving twins and from Mycobacterium leprae genomic, as well epidemiological observations of leprosy have shown the importance of the human genetic as determinant of the disease’s course, from the resistance, to the immunological dichotomy which defines tuberculoid and lepromatous poles. Thus, studies using genome-wide scan and association methods have shown some genomic regions whose alterations are candidates to risk factors for leprosy. However, these associations are weak and are not repeated in all different studies, which put in evidence the divergence in risk factors for different populations as well in design studies as causatives of this controversial data. In this manner, this review has as purpose the data collection which have already been described about human genomic regions that must participate in the genetic control of leprosyDados de investigações familiares, de estudos com gêmeos e da genômica do Mycobacterium leprae, bem como observações sobre a epidemiologia da hanseníase, têm apontado a importância da genética humana como determinante do curso da doença desde a resistência à dicotomia imunológica que definem os pólos tuberculóide e virchowiano. Nesse contexto, estudos de varredura genômica e de associação têm apontado algumas regiões genômicas cujas variações são candidatas a fatores de risco para a doença. Entretanto, as associações já descritas são discretas e não se replicam em todos os estudos, o que evidencia a distinção entre os fatores de risco para diferentes populações, além de divergências nos desenhos destes estudos, como causadores destas controvérsias. Assim, esta revisão tem o propósito de compilação dos dados já descritos para as diversas regiões genômicas humanas que devem participar do controle genético da hanseníase.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2007-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3519910.47878/hi.2007.v32.35199Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 32 No. 1 (2007); 81-93Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 32 n. 1 (2007); 81-931982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35199/33665Souza, Vânia Nieto Brito dePereira, Ana Carlainfo:eu-repo/semantics/openAccess2022-02-17T19:03:20Zoai:ojs.periodicos.saude.sp.gov.br:article/35199Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2022-02-17T19:03:20Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Human genetic in leprosy susceptibility
Genética humana na susceptibilidade à hanseníase
title Human genetic in leprosy susceptibility
spellingShingle Human genetic in leprosy susceptibility
Souza, Vânia Nieto Brito de
hanseníase
polimorfismo de um único nucleotídeo
susceptibilidade genética
leprosy
single nucleotide polymorphism
genetic susceptibility
title_short Human genetic in leprosy susceptibility
title_full Human genetic in leprosy susceptibility
title_fullStr Human genetic in leprosy susceptibility
title_full_unstemmed Human genetic in leprosy susceptibility
title_sort Human genetic in leprosy susceptibility
author Souza, Vânia Nieto Brito de
author_facet Souza, Vânia Nieto Brito de
Pereira, Ana Carla
author_role author
author2 Pereira, Ana Carla
author2_role author
dc.contributor.author.fl_str_mv Souza, Vânia Nieto Brito de
Pereira, Ana Carla
dc.subject.por.fl_str_mv hanseníase
polimorfismo de um único nucleotídeo
susceptibilidade genética
leprosy
single nucleotide polymorphism
genetic susceptibility
topic hanseníase
polimorfismo de um único nucleotídeo
susceptibilidade genética
leprosy
single nucleotide polymorphism
genetic susceptibility
description Data from familiar investigations, studies involving twins and from Mycobacterium leprae genomic, as well epidemiological observations of leprosy have shown the importance of the human genetic as determinant of the disease’s course, from the resistance, to the immunological dichotomy which defines tuberculoid and lepromatous poles. Thus, studies using genome-wide scan and association methods have shown some genomic regions whose alterations are candidates to risk factors for leprosy. However, these associations are weak and are not repeated in all different studies, which put in evidence the divergence in risk factors for different populations as well in design studies as causatives of this controversial data. In this manner, this review has as purpose the data collection which have already been described about human genomic regions that must participate in the genetic control of leprosy
publishDate 2007
dc.date.none.fl_str_mv 2007-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199
10.47878/hi.2007.v32.35199
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199
identifier_str_mv 10.47878/hi.2007.v32.35199
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199/33665
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 32 No. 1 (2007); 81-93
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 32 n. 1 (2007); 81-93
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
_version_ 1796797578887561216

Registros relacionados