Human genetic in leprosy susceptibility
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Hansenologia Internationalis (Online) |
Texto Completo: | https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199 |
Resumo: | Data from familiar investigations, studies involving twins and from Mycobacterium leprae genomic, as well epidemiological observations of leprosy have shown the importance of the human genetic as determinant of the disease’s course, from the resistance, to the immunological dichotomy which defines tuberculoid and lepromatous poles. Thus, studies using genome-wide scan and association methods have shown some genomic regions whose alterations are candidates to risk factors for leprosy. However, these associations are weak and are not repeated in all different studies, which put in evidence the divergence in risk factors for different populations as well in design studies as causatives of this controversial data. In this manner, this review has as purpose the data collection which have already been described about human genomic regions that must participate in the genetic control of leprosy |
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Human genetic in leprosy susceptibilityGenética humana na susceptibilidade à hanseníasehanseníasepolimorfismo de um único nucleotídeosusceptibilidade genéticaleprosysingle nucleotide polymorphismgenetic susceptibilityData from familiar investigations, studies involving twins and from Mycobacterium leprae genomic, as well epidemiological observations of leprosy have shown the importance of the human genetic as determinant of the disease’s course, from the resistance, to the immunological dichotomy which defines tuberculoid and lepromatous poles. Thus, studies using genome-wide scan and association methods have shown some genomic regions whose alterations are candidates to risk factors for leprosy. However, these associations are weak and are not repeated in all different studies, which put in evidence the divergence in risk factors for different populations as well in design studies as causatives of this controversial data. In this manner, this review has as purpose the data collection which have already been described about human genomic regions that must participate in the genetic control of leprosyDados de investigações familiares, de estudos com gêmeos e da genômica do Mycobacterium leprae, bem como observações sobre a epidemiologia da hanseníase, têm apontado a importância da genética humana como determinante do curso da doença desde a resistência à dicotomia imunológica que definem os pólos tuberculóide e virchowiano. Nesse contexto, estudos de varredura genômica e de associação têm apontado algumas regiões genômicas cujas variações são candidatas a fatores de risco para a doença. Entretanto, as associações já descritas são discretas e não se replicam em todos os estudos, o que evidencia a distinção entre os fatores de risco para diferentes populações, além de divergências nos desenhos destes estudos, como causadores destas controvérsias. Assim, esta revisão tem o propósito de compilação dos dados já descritos para as diversas regiões genômicas humanas que devem participar do controle genético da hanseníase.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2007-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3519910.47878/hi.2007.v32.35199Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 32 No. 1 (2007); 81-93Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 32 n. 1 (2007); 81-931982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35199/33665Souza, Vânia Nieto Brito dePereira, Ana Carlainfo:eu-repo/semantics/openAccess2022-02-17T19:03:20Zoai:ojs.periodicos.saude.sp.gov.br:article/35199Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2022-02-17T19:03:20Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false |
dc.title.none.fl_str_mv |
Human genetic in leprosy susceptibility Genética humana na susceptibilidade à hanseníase |
title |
Human genetic in leprosy susceptibility |
spellingShingle |
Human genetic in leprosy susceptibility Souza, Vânia Nieto Brito de hanseníase polimorfismo de um único nucleotídeo susceptibilidade genética leprosy single nucleotide polymorphism genetic susceptibility |
title_short |
Human genetic in leprosy susceptibility |
title_full |
Human genetic in leprosy susceptibility |
title_fullStr |
Human genetic in leprosy susceptibility |
title_full_unstemmed |
Human genetic in leprosy susceptibility |
title_sort |
Human genetic in leprosy susceptibility |
author |
Souza, Vânia Nieto Brito de |
author_facet |
Souza, Vânia Nieto Brito de Pereira, Ana Carla |
author_role |
author |
author2 |
Pereira, Ana Carla |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Souza, Vânia Nieto Brito de Pereira, Ana Carla |
dc.subject.por.fl_str_mv |
hanseníase polimorfismo de um único nucleotídeo susceptibilidade genética leprosy single nucleotide polymorphism genetic susceptibility |
topic |
hanseníase polimorfismo de um único nucleotídeo susceptibilidade genética leprosy single nucleotide polymorphism genetic susceptibility |
description |
Data from familiar investigations, studies involving twins and from Mycobacterium leprae genomic, as well epidemiological observations of leprosy have shown the importance of the human genetic as determinant of the disease’s course, from the resistance, to the immunological dichotomy which defines tuberculoid and lepromatous poles. Thus, studies using genome-wide scan and association methods have shown some genomic regions whose alterations are candidates to risk factors for leprosy. However, these associations are weak and are not repeated in all different studies, which put in evidence the divergence in risk factors for different populations as well in design studies as causatives of this controversial data. In this manner, this review has as purpose the data collection which have already been described about human genomic regions that must participate in the genetic control of leprosy |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-06-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199 10.47878/hi.2007.v32.35199 |
url |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199 |
identifier_str_mv |
10.47878/hi.2007.v32.35199 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199/33665 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
dc.source.none.fl_str_mv |
Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 32 No. 1 (2007); 81-93 Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 32 n. 1 (2007); 81-93 1982-5161 reponame:Hansenologia Internationalis (Online) instname:Instituto Lauro de Souza Lima (ILSL) instacron:ILSL |
instname_str |
Instituto Lauro de Souza Lima (ILSL) |
instacron_str |
ILSL |
institution |
ILSL |
reponame_str |
Hansenologia Internationalis (Online) |
collection |
Hansenologia Internationalis (Online) |
repository.name.fl_str_mv |
Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL) |
repository.mail.fl_str_mv |
hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br |
_version_ |
1796797578887561216 |