Mast cell and Mycobacterium leprae in experimental leprosy

Detalhes bibliográficos
Autor(a) principal: KUMAR, R.
Data de Publicação: 1982
Outros Autores: VAIDYA , M. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Hansenologia Internationalis (Online)
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35595
Resumo: The association of mast cells and lepra bacilli was studied in the foot pad skin of immunosuppressed mice inoculated with 105 lepra bacilli. The mice were killed at intervals varying from 2½ — 14 months postinoculation. M. leprae are found in large numbers in nerves, blood vessels, muscle fibres, hair follicles, sweat and sebaceous glands. Mastocytosis and extensive degranulation are seen at similar sites. Since these are the structures most affected in leprosy where the lepra bacilli and degranulating mast cells accumulate, there appears a close relationship between the two. This could be due to the composite role of mast cells in host tissue response and mastocytosis and degra-nulation may be related to this.
id ILSL-1_edf6620f0e4dfe0d8f9882194cfc8185
oai_identifier_str oai:ojs.periodicos.saude.sp.gov.br:article/35595
network_acronym_str ILSL-1
network_name_str Hansenologia Internationalis (Online)
repository_id_str
spelling Mast cell and Mycobacterium leprae in experimental leprosyHanseníase experimentalMycobacterium lepraeMastócitosExperimental leprosyMycobacterium lepraeMast cellsThe association of mast cells and lepra bacilli was studied in the foot pad skin of immunosuppressed mice inoculated with 105 lepra bacilli. The mice were killed at intervals varying from 2½ — 14 months postinoculation. M. leprae are found in large numbers in nerves, blood vessels, muscle fibres, hair follicles, sweat and sebaceous glands. Mastocytosis and extensive degranulation are seen at similar sites. Since these are the structures most affected in leprosy where the lepra bacilli and degranulating mast cells accumulate, there appears a close relationship between the two. This could be due to the composite role of mast cells in host tissue response and mastocytosis and degra-nulation may be related to this.A associação de mastócitos e bacilos de Hansen foi estudada na pele do coxim plantar de camundongos timectomizados e submetidos a 900r de radiação total inoculados com 105 M. leprae. Os camundongos foram mortos em intervalos que variaram de 2 e meio a 14 meses após a inoculação. Bacilos foram encontrados em grande quantidade nos nervos, vasos sangüíneos, fibras musculares, folículos pilosos, glândulas sudoríparas e sebáceas. Mastocitose e granulação extensa foram observadas nesses sítios. Já que estas estruturas são as mais afetadas na hanseníase, nas quais os bacilos e os mastócitos granulosos se acumulam, parece haver uma estreita correlação entre os dois. Isto pode ser devido ao desempenho múltiplo dos mastócitos na resposta dos tecidos hospedeiros; a mastocitose e a granulação podem estar relacionadas com esses fatos. Tradução do Editor.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo1982-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3559510.47878/hi.1982.v7.35595Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 7 No. 1 (1982); 1-7Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 7 n. 1 (1982); 1-71982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLenghttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35595/33998KUMAR, R.VAIDYA , M. C.info:eu-repo/semantics/openAccess2021-06-06T04:36:50Zoai:ojs.periodicos.saude.sp.gov.br:article/35595Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2021-06-06T04:36:50Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Mast cell and Mycobacterium leprae in experimental leprosy
title Mast cell and Mycobacterium leprae in experimental leprosy
spellingShingle Mast cell and Mycobacterium leprae in experimental leprosy
KUMAR, R.
Hanseníase experimental
Mycobacterium leprae
Mastócitos
Experimental leprosy
Mycobacterium leprae
Mast cells
title_short Mast cell and Mycobacterium leprae in experimental leprosy
title_full Mast cell and Mycobacterium leprae in experimental leprosy
title_fullStr Mast cell and Mycobacterium leprae in experimental leprosy
title_full_unstemmed Mast cell and Mycobacterium leprae in experimental leprosy
title_sort Mast cell and Mycobacterium leprae in experimental leprosy
author KUMAR, R.
author_facet KUMAR, R.
VAIDYA , M. C.
author_role author
author2 VAIDYA , M. C.
author2_role author
dc.contributor.author.fl_str_mv KUMAR, R.
VAIDYA , M. C.
dc.subject.por.fl_str_mv Hanseníase experimental
Mycobacterium leprae
Mastócitos
Experimental leprosy
Mycobacterium leprae
Mast cells
topic Hanseníase experimental
Mycobacterium leprae
Mastócitos
Experimental leprosy
Mycobacterium leprae
Mast cells
description The association of mast cells and lepra bacilli was studied in the foot pad skin of immunosuppressed mice inoculated with 105 lepra bacilli. The mice were killed at intervals varying from 2½ — 14 months postinoculation. M. leprae are found in large numbers in nerves, blood vessels, muscle fibres, hair follicles, sweat and sebaceous glands. Mastocytosis and extensive degranulation are seen at similar sites. Since these are the structures most affected in leprosy where the lepra bacilli and degranulating mast cells accumulate, there appears a close relationship between the two. This could be due to the composite role of mast cells in host tissue response and mastocytosis and degra-nulation may be related to this.
publishDate 1982
dc.date.none.fl_str_mv 1982-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35595
10.47878/hi.1982.v7.35595
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/35595
identifier_str_mv 10.47878/hi.1982.v7.35595
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35595/33998
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 7 No. 1 (1982); 1-7
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 7 n. 1 (1982); 1-7
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
_version_ 1796797579788288000

Registros relacionados