Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Saúde Materno Infantil (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000601075 |
Resumo: | Abstract Objectives: to evaluate the performance of a trigger tool in identifying adverse drug events (ADE) in hospitalized children. Methods: a retrospective cohort study review on 133 medical records at a federal maternal and child reference hospital in Rio de Janeiro in 2016. A list of 14 triggers was developed to detect ADE in the pediatric population. Three steps were performed: (1) search for triggers; (2) selection of suspected cases of ADE and (3) final determination of ADE by experts’ consensus. Results: 360 triggers were identified in 100 hospitalizations (75.2%), with an average of 2.7 triggers/ hospitalization. The most frequent triggers were “abrupt medication stop” (79.7%); “antiemetics use” (8.9%) and “laxatives use” (7.2%); while the “diphenhydramine use”, “phytomenadione use” and “excessive sedation/lethargy/fall/hypotension” obtained the highest performance indicating ADE every time they occurred. Thirty-one ADE were identified in 12.8% of the hospitalizations; 11 (35.5%) ADE were detected without the aid of the triggers thus, pruritus and diarrhea were the most frequent. Conclusion: the trigger tool proved to be useful in identifying ADE in hospitalized children, especially if high performance and high frequency triggers are used in identifying the events. The inclusion of the triggers “diarrhea” and “pruritus”, may favor the identification of ADE in patients at pediatric wards. |
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Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggersDrug-related side effects and adverse reactionsDrug monitoringPediatric HospitalsHospitalizationPharmacoepidemiologyPatient’s safetyAbstract Objectives: to evaluate the performance of a trigger tool in identifying adverse drug events (ADE) in hospitalized children. Methods: a retrospective cohort study review on 133 medical records at a federal maternal and child reference hospital in Rio de Janeiro in 2016. A list of 14 triggers was developed to detect ADE in the pediatric population. Three steps were performed: (1) search for triggers; (2) selection of suspected cases of ADE and (3) final determination of ADE by experts’ consensus. Results: 360 triggers were identified in 100 hospitalizations (75.2%), with an average of 2.7 triggers/ hospitalization. The most frequent triggers were “abrupt medication stop” (79.7%); “antiemetics use” (8.9%) and “laxatives use” (7.2%); while the “diphenhydramine use”, “phytomenadione use” and “excessive sedation/lethargy/fall/hypotension” obtained the highest performance indicating ADE every time they occurred. Thirty-one ADE were identified in 12.8% of the hospitalizations; 11 (35.5%) ADE were detected without the aid of the triggers thus, pruritus and diarrhea were the most frequent. Conclusion: the trigger tool proved to be useful in identifying ADE in hospitalized children, especially if high performance and high frequency triggers are used in identifying the events. The inclusion of the triggers “diarrhea” and “pruritus”, may favor the identification of ADE in patients at pediatric wards.Instituto de Medicina Integral Prof. Fernando Figueira2021-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000601075Revista Brasileira de Saúde Materno Infantil v.21 n.4 2021reponame:Revista Brasileira de Saúde Materno Infantil (Online)instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)instacron:IMIPFF10.1590/1806-93042021000400007info:eu-repo/semantics/openAccessCaetano,Simone Cristina Rodrigues de CarvalhoSilva,Luiz Fernando Emidio daGuaraldo,LusieleGiordani,Fabíolaeng2022-02-17T00:00:00Zoai:scielo:S1519-38292021000601075Revistahttp://www.scielo.br/rbsmihttps://old.scielo.br/oai/scielo-oai.php||revista@imip.org.br1806-93041519-3829opendoar:2022-02-17T00:00Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)false |
dc.title.none.fl_str_mv |
Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers |
title |
Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers |
spellingShingle |
Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers Caetano,Simone Cristina Rodrigues de Carvalho Drug-related side effects and adverse reactions Drug monitoring Pediatric Hospitals Hospitalization Pharmacoepidemiology Patient’s safety |
title_short |
Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers |
title_full |
Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers |
title_fullStr |
Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers |
title_full_unstemmed |
Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers |
title_sort |
Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers |
author |
Caetano,Simone Cristina Rodrigues de Carvalho |
author_facet |
Caetano,Simone Cristina Rodrigues de Carvalho Silva,Luiz Fernando Emidio da Guaraldo,Lusiele Giordani,Fabíola |
author_role |
author |
author2 |
Silva,Luiz Fernando Emidio da Guaraldo,Lusiele Giordani,Fabíola |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Caetano,Simone Cristina Rodrigues de Carvalho Silva,Luiz Fernando Emidio da Guaraldo,Lusiele Giordani,Fabíola |
dc.subject.por.fl_str_mv |
Drug-related side effects and adverse reactions Drug monitoring Pediatric Hospitals Hospitalization Pharmacoepidemiology Patient’s safety |
topic |
Drug-related side effects and adverse reactions Drug monitoring Pediatric Hospitals Hospitalization Pharmacoepidemiology Patient’s safety |
description |
Abstract Objectives: to evaluate the performance of a trigger tool in identifying adverse drug events (ADE) in hospitalized children. Methods: a retrospective cohort study review on 133 medical records at a federal maternal and child reference hospital in Rio de Janeiro in 2016. A list of 14 triggers was developed to detect ADE in the pediatric population. Three steps were performed: (1) search for triggers; (2) selection of suspected cases of ADE and (3) final determination of ADE by experts’ consensus. Results: 360 triggers were identified in 100 hospitalizations (75.2%), with an average of 2.7 triggers/ hospitalization. The most frequent triggers were “abrupt medication stop” (79.7%); “antiemetics use” (8.9%) and “laxatives use” (7.2%); while the “diphenhydramine use”, “phytomenadione use” and “excessive sedation/lethargy/fall/hypotension” obtained the highest performance indicating ADE every time they occurred. Thirty-one ADE were identified in 12.8% of the hospitalizations; 11 (35.5%) ADE were detected without the aid of the triggers thus, pruritus and diarrhea were the most frequent. Conclusion: the trigger tool proved to be useful in identifying ADE in hospitalized children, especially if high performance and high frequency triggers are used in identifying the events. The inclusion of the triggers “diarrhea” and “pruritus”, may favor the identification of ADE in patients at pediatric wards. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000601075 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000601075 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-93042021000400007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Medicina Integral Prof. Fernando Figueira |
publisher.none.fl_str_mv |
Instituto de Medicina Integral Prof. Fernando Figueira |
dc.source.none.fl_str_mv |
Revista Brasileira de Saúde Materno Infantil v.21 n.4 2021 reponame:Revista Brasileira de Saúde Materno Infantil (Online) instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) instacron:IMIPFF |
instname_str |
Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) |
instacron_str |
IMIPFF |
institution |
IMIPFF |
reponame_str |
Revista Brasileira de Saúde Materno Infantil (Online) |
collection |
Revista Brasileira de Saúde Materno Infantil (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) |
repository.mail.fl_str_mv |
||revista@imip.org.br |
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1752129930818224128 |