Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers

Detalhes bibliográficos
Autor(a) principal: Caetano,Simone Cristina Rodrigues de Carvalho
Data de Publicação: 2021
Outros Autores: Silva,Luiz Fernando Emidio da, Guaraldo,Lusiele, Giordani,Fabíola
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Saúde Materno Infantil (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000601075
Resumo: Abstract Objectives: to evaluate the performance of a trigger tool in identifying adverse drug events (ADE) in hospitalized children. Methods: a retrospective cohort study review on 133 medical records at a federal maternal and child reference hospital in Rio de Janeiro in 2016. A list of 14 triggers was developed to detect ADE in the pediatric population. Three steps were performed: (1) search for triggers; (2) selection of suspected cases of ADE and (3) final determination of ADE by experts’ consensus. Results: 360 triggers were identified in 100 hospitalizations (75.2%), with an average of 2.7 triggers/ hospitalization. The most frequent triggers were “abrupt medication stop” (79.7%); “antiemetics use” (8.9%) and “laxatives use” (7.2%); while the “diphenhydramine use”, “phytomenadione use” and “excessive sedation/lethargy/fall/hypotension” obtained the highest performance indicating ADE every time they occurred. Thirty-one ADE were identified in 12.8% of the hospitalizations; 11 (35.5%) ADE were detected without the aid of the triggers thus, pruritus and diarrhea were the most frequent. Conclusion: the trigger tool proved to be useful in identifying ADE in hospitalized children, especially if high performance and high frequency triggers are used in identifying the events. The inclusion of the triggers “diarrhea” and “pruritus”, may favor the identification of ADE in patients at pediatric wards.
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spelling Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggersDrug-related side effects and adverse reactionsDrug monitoringPediatric HospitalsHospitalizationPharmacoepidemiologyPatient’s safetyAbstract Objectives: to evaluate the performance of a trigger tool in identifying adverse drug events (ADE) in hospitalized children. Methods: a retrospective cohort study review on 133 medical records at a federal maternal and child reference hospital in Rio de Janeiro in 2016. A list of 14 triggers was developed to detect ADE in the pediatric population. Three steps were performed: (1) search for triggers; (2) selection of suspected cases of ADE and (3) final determination of ADE by experts’ consensus. Results: 360 triggers were identified in 100 hospitalizations (75.2%), with an average of 2.7 triggers/ hospitalization. The most frequent triggers were “abrupt medication stop” (79.7%); “antiemetics use” (8.9%) and “laxatives use” (7.2%); while the “diphenhydramine use”, “phytomenadione use” and “excessive sedation/lethargy/fall/hypotension” obtained the highest performance indicating ADE every time they occurred. Thirty-one ADE were identified in 12.8% of the hospitalizations; 11 (35.5%) ADE were detected without the aid of the triggers thus, pruritus and diarrhea were the most frequent. Conclusion: the trigger tool proved to be useful in identifying ADE in hospitalized children, especially if high performance and high frequency triggers are used in identifying the events. The inclusion of the triggers “diarrhea” and “pruritus”, may favor the identification of ADE in patients at pediatric wards.Instituto de Medicina Integral Prof. Fernando Figueira2021-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000601075Revista Brasileira de Saúde Materno Infantil v.21 n.4 2021reponame:Revista Brasileira de Saúde Materno Infantil (Online)instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)instacron:IMIPFF10.1590/1806-93042021000400007info:eu-repo/semantics/openAccessCaetano,Simone Cristina Rodrigues de CarvalhoSilva,Luiz Fernando Emidio daGuaraldo,LusieleGiordani,Fabíolaeng2022-02-17T00:00:00Zoai:scielo:S1519-38292021000601075Revistahttp://www.scielo.br/rbsmihttps://old.scielo.br/oai/scielo-oai.php||revista@imip.org.br1806-93041519-3829opendoar:2022-02-17T00:00Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)false
dc.title.none.fl_str_mv Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
title Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
spellingShingle Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
Caetano,Simone Cristina Rodrigues de Carvalho
Drug-related side effects and adverse reactions
Drug monitoring
Pediatric Hospitals
Hospitalization
Pharmacoepidemiology
Patient’s safety
title_short Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
title_full Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
title_fullStr Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
title_full_unstemmed Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
title_sort Identifying adverse drug events in patients at a pediatric ward in a Brazilian hospital: application and performance of the triggers
author Caetano,Simone Cristina Rodrigues de Carvalho
author_facet Caetano,Simone Cristina Rodrigues de Carvalho
Silva,Luiz Fernando Emidio da
Guaraldo,Lusiele
Giordani,Fabíola
author_role author
author2 Silva,Luiz Fernando Emidio da
Guaraldo,Lusiele
Giordani,Fabíola
author2_role author
author
author
dc.contributor.author.fl_str_mv Caetano,Simone Cristina Rodrigues de Carvalho
Silva,Luiz Fernando Emidio da
Guaraldo,Lusiele
Giordani,Fabíola
dc.subject.por.fl_str_mv Drug-related side effects and adverse reactions
Drug monitoring
Pediatric Hospitals
Hospitalization
Pharmacoepidemiology
Patient’s safety
topic Drug-related side effects and adverse reactions
Drug monitoring
Pediatric Hospitals
Hospitalization
Pharmacoepidemiology
Patient’s safety
description Abstract Objectives: to evaluate the performance of a trigger tool in identifying adverse drug events (ADE) in hospitalized children. Methods: a retrospective cohort study review on 133 medical records at a federal maternal and child reference hospital in Rio de Janeiro in 2016. A list of 14 triggers was developed to detect ADE in the pediatric population. Three steps were performed: (1) search for triggers; (2) selection of suspected cases of ADE and (3) final determination of ADE by experts’ consensus. Results: 360 triggers were identified in 100 hospitalizations (75.2%), with an average of 2.7 triggers/ hospitalization. The most frequent triggers were “abrupt medication stop” (79.7%); “antiemetics use” (8.9%) and “laxatives use” (7.2%); while the “diphenhydramine use”, “phytomenadione use” and “excessive sedation/lethargy/fall/hypotension” obtained the highest performance indicating ADE every time they occurred. Thirty-one ADE were identified in 12.8% of the hospitalizations; 11 (35.5%) ADE were detected without the aid of the triggers thus, pruritus and diarrhea were the most frequent. Conclusion: the trigger tool proved to be useful in identifying ADE in hospitalized children, especially if high performance and high frequency triggers are used in identifying the events. The inclusion of the triggers “diarrhea” and “pruritus”, may favor the identification of ADE in patients at pediatric wards.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000601075
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000601075
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-93042021000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Medicina Integral Prof. Fernando Figueira
publisher.none.fl_str_mv Instituto de Medicina Integral Prof. Fernando Figueira
dc.source.none.fl_str_mv Revista Brasileira de Saúde Materno Infantil v.21 n.4 2021
reponame:Revista Brasileira de Saúde Materno Infantil (Online)
instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
instacron:IMIPFF
instname_str Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
instacron_str IMIPFF
institution IMIPFF
reponame_str Revista Brasileira de Saúde Materno Infantil (Online)
collection Revista Brasileira de Saúde Materno Infantil (Online)
repository.name.fl_str_mv Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
repository.mail.fl_str_mv ||revista@imip.org.br
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