Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data

Detalhes bibliográficos
Autor(a) principal: Silva, Lunara Teles
Data de Publicação: 2022
Outros Autores: Modesto, Ana Carolina Figueiredo, Oliveira, Rodrigo Alves de, Amaral, Rita Goreti, Lopes, Flavio Marques
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/203522
Resumo: OBJECTIVE To describe the frequency and characteristics of hospitalizations for/with adverse drug events in the Brazilian unified health system routine data. METHODS Nationwide retrospective study using data obtained from a period of ten years from the Brazil Hospital Information System (SIH-SUS), an administrative database that registers hospitalizations in the unified health system. We selected hospitalizations with primary and/or secondary diagnosis related to adverse drug events according to a list of validated International Classification Disease 10th edition (ICD-10) codes. These events were described according to year, age group, sex, length of hospital stay, mortality, hospital costs, Brazilian geographical region, and category of ICD-10 codes. Crude hospitalization rates of adverse drug events per 100,000 inhabitants were obtained and Joinpoint Regression was used to analyze temporal changes in these rates along the years. The most frequent ICD-10 codes were also identified. RESULTS Over ten years, 603,663 hospitalizations in Brazil were found in the database, out of which 2.5% of the patients died. Though 2009 had the highest prevalence of hospitalization per 100,000 inhabitants (32.57), no significant annual change in rates was found for the entire period. All age groups and sexes presented a jointpoint in temporal series; however, only women had a significative increase trend. The most frequent codes were from the chapter of mental and behavioral disorders (F19.2, F19.0, and F19.5 codes). CONCLUSIONS The database methodology can be useful to estimate frequencies of adverse drug events and perform characterization nationwide and to help monitor morbidity along the years.
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spelling Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine dataDrug-related side effects and adverse reactionsPharmacoepidemiologyHospitalizationDatabases, factualOBJECTIVE To describe the frequency and characteristics of hospitalizations for/with adverse drug events in the Brazilian unified health system routine data. METHODS Nationwide retrospective study using data obtained from a period of ten years from the Brazil Hospital Information System (SIH-SUS), an administrative database that registers hospitalizations in the unified health system. We selected hospitalizations with primary and/or secondary diagnosis related to adverse drug events according to a list of validated International Classification Disease 10th edition (ICD-10) codes. These events were described according to year, age group, sex, length of hospital stay, mortality, hospital costs, Brazilian geographical region, and category of ICD-10 codes. Crude hospitalization rates of adverse drug events per 100,000 inhabitants were obtained and Joinpoint Regression was used to analyze temporal changes in these rates along the years. The most frequent ICD-10 codes were also identified. RESULTS Over ten years, 603,663 hospitalizations in Brazil were found in the database, out of which 2.5% of the patients died. Though 2009 had the highest prevalence of hospitalization per 100,000 inhabitants (32.57), no significant annual change in rates was found for the entire period. All age groups and sexes presented a jointpoint in temporal series; however, only women had a significative increase trend. The most frequent codes were from the chapter of mental and behavioral disorders (F19.2, F19.0, and F19.5 codes). CONCLUSIONS The database methodology can be useful to estimate frequencies of adverse drug events and perform characterization nationwide and to help monitor morbidity along the years.Universidade de São Paulo. Faculdade de Saúde Pública2022-10-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/xmlhttps://www.revistas.usp.br/rsp/article/view/20352210.11606/s1518-8787.2022056003913Revista de Saúde Pública; Vol. 56 (2022); 86Revista de Saúde Pública; Vol. 56 (2022); 86Revista de Saúde Pública; v. 56 (2022); 861518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/203522/187472https://www.revistas.usp.br/rsp/article/view/203522/187471Copyright (c) 2022 Lunara Teles Silva, Ana Carolina Figueiredo Modesto, Rodrigo Alves de Oliveira, Rita Goreti Amaral, Flavio Marques Lopeshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Lunara TelesModesto, Ana Carolina Figueiredo Oliveira, Rodrigo Alves de Amaral, Rita Goreti Lopes, Flavio Marques 2022-10-14T15:02:14Zoai:revistas.usp.br:article/203522Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2022-10-14T15:02:14Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
title Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
spellingShingle Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
Silva, Lunara Teles
Drug-related side effects and adverse reactions
Pharmacoepidemiology
Hospitalization
Databases, factual
title_short Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
title_full Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
title_fullStr Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
title_full_unstemmed Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
title_sort Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
author Silva, Lunara Teles
author_facet Silva, Lunara Teles
Modesto, Ana Carolina Figueiredo
Oliveira, Rodrigo Alves de
Amaral, Rita Goreti
Lopes, Flavio Marques
author_role author
author2 Modesto, Ana Carolina Figueiredo
Oliveira, Rodrigo Alves de
Amaral, Rita Goreti
Lopes, Flavio Marques
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Lunara Teles
Modesto, Ana Carolina Figueiredo
Oliveira, Rodrigo Alves de
Amaral, Rita Goreti
Lopes, Flavio Marques
dc.subject.por.fl_str_mv Drug-related side effects and adverse reactions
Pharmacoepidemiology
Hospitalization
Databases, factual
topic Drug-related side effects and adverse reactions
Pharmacoepidemiology
Hospitalization
Databases, factual
description OBJECTIVE To describe the frequency and characteristics of hospitalizations for/with adverse drug events in the Brazilian unified health system routine data. METHODS Nationwide retrospective study using data obtained from a period of ten years from the Brazil Hospital Information System (SIH-SUS), an administrative database that registers hospitalizations in the unified health system. We selected hospitalizations with primary and/or secondary diagnosis related to adverse drug events according to a list of validated International Classification Disease 10th edition (ICD-10) codes. These events were described according to year, age group, sex, length of hospital stay, mortality, hospital costs, Brazilian geographical region, and category of ICD-10 codes. Crude hospitalization rates of adverse drug events per 100,000 inhabitants were obtained and Joinpoint Regression was used to analyze temporal changes in these rates along the years. The most frequent ICD-10 codes were also identified. RESULTS Over ten years, 603,663 hospitalizations in Brazil were found in the database, out of which 2.5% of the patients died. Though 2009 had the highest prevalence of hospitalization per 100,000 inhabitants (32.57), no significant annual change in rates was found for the entire period. All age groups and sexes presented a jointpoint in temporal series; however, only women had a significative increase trend. The most frequent codes were from the chapter of mental and behavioral disorders (F19.2, F19.0, and F19.5 codes). CONCLUSIONS The database methodology can be useful to estimate frequencies of adverse drug events and perform characterization nationwide and to help monitor morbidity along the years.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-10
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dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/203522
10.11606/s1518-8787.2022056003913
url https://www.revistas.usp.br/rsp/article/view/203522
identifier_str_mv 10.11606/s1518-8787.2022056003913
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/203522/187472
https://www.revistas.usp.br/rsp/article/view/203522/187471
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
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dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 56 (2022); 86
Revista de Saúde Pública; Vol. 56 (2022); 86
Revista de Saúde Pública; v. 56 (2022); 86
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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