Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Saúde Materno Infantil (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000300219 |
Resumo: | Abstract Objectives: to review studies that used case-control design to verify the association of polymorphisms in VEGF and KDR genes in the development of endometriosis. Methods: the systematic review selected articles published until September 1, 2015 from PubMed, MEDLINE, BVS, SciELO databases, considering the following key words: endometriosis and ("polymorphism" or "SNP" or "genetic polymorphism") and ("VEGF" OR "Vascular endothelial growth factor" or "VEGFR-2" or "Vascular endothelial growth factor-2" or "KDR" or "Kinase Insert Domain Receptor"). Results: 106 articles were identified, only 11 were eligible. Discrepant results were observed regarding polymorphisms in VEGF gene in the development of endometriosis, which can be explained by methodological differences, sample size, eligible control type, using the unadjusted risk estimates and the heterogeneity of the studied population. Only one study investigated polymorphisms in KDR gene in the development of endometriosis, however it was ineligible for this review. Conclusions: to avoid discrepancy in the results, we suggest that the ideal control group should be formed by fertile women and free of gynecological diseases. Multicentric studies with adequate design, involving different population besides the combined analysis on polymorphisms in VEGF and KDR genes are still necessary to contribute in the understanding of this disease, which are social, clinical and economical problems. |
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Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic reviewEndometriosisVEGFKDRPolymorphismInfertilitAbstract Objectives: to review studies that used case-control design to verify the association of polymorphisms in VEGF and KDR genes in the development of endometriosis. Methods: the systematic review selected articles published until September 1, 2015 from PubMed, MEDLINE, BVS, SciELO databases, considering the following key words: endometriosis and ("polymorphism" or "SNP" or "genetic polymorphism") and ("VEGF" OR "Vascular endothelial growth factor" or "VEGFR-2" or "Vascular endothelial growth factor-2" or "KDR" or "Kinase Insert Domain Receptor"). Results: 106 articles were identified, only 11 were eligible. Discrepant results were observed regarding polymorphisms in VEGF gene in the development of endometriosis, which can be explained by methodological differences, sample size, eligible control type, using the unadjusted risk estimates and the heterogeneity of the studied population. Only one study investigated polymorphisms in KDR gene in the development of endometriosis, however it was ineligible for this review. Conclusions: to avoid discrepancy in the results, we suggest that the ideal control group should be formed by fertile women and free of gynecological diseases. Multicentric studies with adequate design, involving different population besides the combined analysis on polymorphisms in VEGF and KDR genes are still necessary to contribute in the understanding of this disease, which are social, clinical and economical problems.Instituto de Medicina Integral Prof. Fernando Figueira2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000300219Revista Brasileira de Saúde Materno Infantil v.16 n.3 2016reponame:Revista Brasileira de Saúde Materno Infantil (Online)instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)instacron:IMIPFF10.1590/1806-93042016000300002info:eu-repo/semantics/openAccessCardoso,Jessica VilarinhoMachado,Daniel EscorsimFerrari,RenatoSilva,Mayara Calixto daBerardo,Plínio TostesPerini,Jamila Alessandraeng2016-10-20T00:00:00Zoai:scielo:S1519-38292016000300219Revistahttp://www.scielo.br/rbsmihttps://old.scielo.br/oai/scielo-oai.php||revista@imip.org.br1806-93041519-3829opendoar:2016-10-20T00:00Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)false |
dc.title.none.fl_str_mv |
Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review |
title |
Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review |
spellingShingle |
Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review Cardoso,Jessica Vilarinho Endometriosis VEGF KDR Polymorphism Infertilit |
title_short |
Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review |
title_full |
Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review |
title_fullStr |
Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review |
title_full_unstemmed |
Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review |
title_sort |
Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review |
author |
Cardoso,Jessica Vilarinho |
author_facet |
Cardoso,Jessica Vilarinho Machado,Daniel Escorsim Ferrari,Renato Silva,Mayara Calixto da Berardo,Plínio Tostes Perini,Jamila Alessandra |
author_role |
author |
author2 |
Machado,Daniel Escorsim Ferrari,Renato Silva,Mayara Calixto da Berardo,Plínio Tostes Perini,Jamila Alessandra |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cardoso,Jessica Vilarinho Machado,Daniel Escorsim Ferrari,Renato Silva,Mayara Calixto da Berardo,Plínio Tostes Perini,Jamila Alessandra |
dc.subject.por.fl_str_mv |
Endometriosis VEGF KDR Polymorphism Infertilit |
topic |
Endometriosis VEGF KDR Polymorphism Infertilit |
description |
Abstract Objectives: to review studies that used case-control design to verify the association of polymorphisms in VEGF and KDR genes in the development of endometriosis. Methods: the systematic review selected articles published until September 1, 2015 from PubMed, MEDLINE, BVS, SciELO databases, considering the following key words: endometriosis and ("polymorphism" or "SNP" or "genetic polymorphism") and ("VEGF" OR "Vascular endothelial growth factor" or "VEGFR-2" or "Vascular endothelial growth factor-2" or "KDR" or "Kinase Insert Domain Receptor"). Results: 106 articles were identified, only 11 were eligible. Discrepant results were observed regarding polymorphisms in VEGF gene in the development of endometriosis, which can be explained by methodological differences, sample size, eligible control type, using the unadjusted risk estimates and the heterogeneity of the studied population. Only one study investigated polymorphisms in KDR gene in the development of endometriosis, however it was ineligible for this review. Conclusions: to avoid discrepancy in the results, we suggest that the ideal control group should be formed by fertile women and free of gynecological diseases. Multicentric studies with adequate design, involving different population besides the combined analysis on polymorphisms in VEGF and KDR genes are still necessary to contribute in the understanding of this disease, which are social, clinical and economical problems. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000300219 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000300219 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-93042016000300002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Medicina Integral Prof. Fernando Figueira |
publisher.none.fl_str_mv |
Instituto de Medicina Integral Prof. Fernando Figueira |
dc.source.none.fl_str_mv |
Revista Brasileira de Saúde Materno Infantil v.16 n.3 2016 reponame:Revista Brasileira de Saúde Materno Infantil (Online) instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) instacron:IMIPFF |
instname_str |
Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) |
instacron_str |
IMIPFF |
institution |
IMIPFF |
reponame_str |
Revista Brasileira de Saúde Materno Infantil (Online) |
collection |
Revista Brasileira de Saúde Materno Infantil (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) |
repository.mail.fl_str_mv |
||revista@imip.org.br |
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1752129929497018368 |