Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review

Detalhes bibliográficos
Autor(a) principal: Cardoso,Jessica Vilarinho
Data de Publicação: 2016
Outros Autores: Machado,Daniel Escorsim, Ferrari,Renato, Silva,Mayara Calixto da, Berardo,Plínio Tostes, Perini,Jamila Alessandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Saúde Materno Infantil (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000300219
Resumo: Abstract Objectives: to review studies that used case-control design to verify the association of polymorphisms in VEGF and KDR genes in the development of endometriosis. Methods: the systematic review selected articles published until September 1, 2015 from PubMed, MEDLINE, BVS, SciELO databases, considering the following key words: endometriosis and ("polymorphism" or "SNP" or "genetic polymorphism") and ("VEGF" OR "Vascular endothelial growth factor" or "VEGFR-2" or "Vascular endothelial growth factor-2" or "KDR" or "Kinase Insert Domain Receptor"). Results: 106 articles were identified, only 11 were eligible. Discrepant results were observed regarding polymorphisms in VEGF gene in the development of endometriosis, which can be explained by methodological differences, sample size, eligible control type, using the unadjusted risk estimates and the heterogeneity of the studied population. Only one study investigated polymorphisms in KDR gene in the development of endometriosis, however it was ineligible for this review. Conclusions: to avoid discrepancy in the results, we suggest that the ideal control group should be formed by fertile women and free of gynecological diseases. Multicentric studies with adequate design, involving different population besides the combined analysis on polymorphisms in VEGF and KDR genes are still necessary to contribute in the understanding of this disease, which are social, clinical and economical problems.
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spelling Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic reviewEndometriosisVEGFKDRPolymorphismInfertilitAbstract Objectives: to review studies that used case-control design to verify the association of polymorphisms in VEGF and KDR genes in the development of endometriosis. Methods: the systematic review selected articles published until September 1, 2015 from PubMed, MEDLINE, BVS, SciELO databases, considering the following key words: endometriosis and ("polymorphism" or "SNP" or "genetic polymorphism") and ("VEGF" OR "Vascular endothelial growth factor" or "VEGFR-2" or "Vascular endothelial growth factor-2" or "KDR" or "Kinase Insert Domain Receptor"). Results: 106 articles were identified, only 11 were eligible. Discrepant results were observed regarding polymorphisms in VEGF gene in the development of endometriosis, which can be explained by methodological differences, sample size, eligible control type, using the unadjusted risk estimates and the heterogeneity of the studied population. Only one study investigated polymorphisms in KDR gene in the development of endometriosis, however it was ineligible for this review. Conclusions: to avoid discrepancy in the results, we suggest that the ideal control group should be formed by fertile women and free of gynecological diseases. Multicentric studies with adequate design, involving different population besides the combined analysis on polymorphisms in VEGF and KDR genes are still necessary to contribute in the understanding of this disease, which are social, clinical and economical problems.Instituto de Medicina Integral Prof. Fernando Figueira2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000300219Revista Brasileira de Saúde Materno Infantil v.16 n.3 2016reponame:Revista Brasileira de Saúde Materno Infantil (Online)instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)instacron:IMIPFF10.1590/1806-93042016000300002info:eu-repo/semantics/openAccessCardoso,Jessica VilarinhoMachado,Daniel EscorsimFerrari,RenatoSilva,Mayara Calixto daBerardo,Plínio TostesPerini,Jamila Alessandraeng2016-10-20T00:00:00Zoai:scielo:S1519-38292016000300219Revistahttp://www.scielo.br/rbsmihttps://old.scielo.br/oai/scielo-oai.php||revista@imip.org.br1806-93041519-3829opendoar:2016-10-20T00:00Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)false
dc.title.none.fl_str_mv Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
title Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
spellingShingle Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
Cardoso,Jessica Vilarinho
Endometriosis
VEGF
KDR
Polymorphism
Infertilit
title_short Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
title_full Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
title_fullStr Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
title_full_unstemmed Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
title_sort Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review
author Cardoso,Jessica Vilarinho
author_facet Cardoso,Jessica Vilarinho
Machado,Daniel Escorsim
Ferrari,Renato
Silva,Mayara Calixto da
Berardo,Plínio Tostes
Perini,Jamila Alessandra
author_role author
author2 Machado,Daniel Escorsim
Ferrari,Renato
Silva,Mayara Calixto da
Berardo,Plínio Tostes
Perini,Jamila Alessandra
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso,Jessica Vilarinho
Machado,Daniel Escorsim
Ferrari,Renato
Silva,Mayara Calixto da
Berardo,Plínio Tostes
Perini,Jamila Alessandra
dc.subject.por.fl_str_mv Endometriosis
VEGF
KDR
Polymorphism
Infertilit
topic Endometriosis
VEGF
KDR
Polymorphism
Infertilit
description Abstract Objectives: to review studies that used case-control design to verify the association of polymorphisms in VEGF and KDR genes in the development of endometriosis. Methods: the systematic review selected articles published until September 1, 2015 from PubMed, MEDLINE, BVS, SciELO databases, considering the following key words: endometriosis and ("polymorphism" or "SNP" or "genetic polymorphism") and ("VEGF" OR "Vascular endothelial growth factor" or "VEGFR-2" or "Vascular endothelial growth factor-2" or "KDR" or "Kinase Insert Domain Receptor"). Results: 106 articles were identified, only 11 were eligible. Discrepant results were observed regarding polymorphisms in VEGF gene in the development of endometriosis, which can be explained by methodological differences, sample size, eligible control type, using the unadjusted risk estimates and the heterogeneity of the studied population. Only one study investigated polymorphisms in KDR gene in the development of endometriosis, however it was ineligible for this review. Conclusions: to avoid discrepancy in the results, we suggest that the ideal control group should be formed by fertile women and free of gynecological diseases. Multicentric studies with adequate design, involving different population besides the combined analysis on polymorphisms in VEGF and KDR genes are still necessary to contribute in the understanding of this disease, which are social, clinical and economical problems.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000300219
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292016000300219
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-93042016000300002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Medicina Integral Prof. Fernando Figueira
publisher.none.fl_str_mv Instituto de Medicina Integral Prof. Fernando Figueira
dc.source.none.fl_str_mv Revista Brasileira de Saúde Materno Infantil v.16 n.3 2016
reponame:Revista Brasileira de Saúde Materno Infantil (Online)
instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
instacron:IMIPFF
instname_str Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
instacron_str IMIPFF
institution IMIPFF
reponame_str Revista Brasileira de Saúde Materno Infantil (Online)
collection Revista Brasileira de Saúde Materno Infantil (Online)
repository.name.fl_str_mv Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)
repository.mail.fl_str_mv ||revista@imip.org.br
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