Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Saúde Materno Infantil (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292018000100179 |
Resumo: | Abstract Objectives: to verify the contribution of polymorphisms rs1800469 and rs1800468 of the TGF-β1 gene and the risk factors for the pre-eclampsia development. Methods: this is a case-control study with 257 women from the Uberaba region of Minas Gerais were selected, 88 of them were in the pre-eclampsia group and 169 in the control group. Genotyping was performed by allelic discrimination using the real-time PCR technique. The odds ratio and the 95% confidence interval were used to evaluate the probability of the polymorphisms studied contributing for the pre-eclampsia development. The logistic regression analysis was performed to evaluate the relation among family recurrence, smoking, primiparity and the presence of polymorphic alleles and susceptibility of preeclampsia. Results: no association was found between polymorphisms rs1800469 and rs1800468 of the TGF-β1 gene and pre-eclampsia. The logistic regression analysis was statistically significant for family recurrence, showing that women with a family history of pre-eclampsia and primiparity are at an increased risk of developing the disease. Conclusions: no association was found between polymorphisms rs1800469 and rs1800468 of the TGF-β1 and pre-eclampsia gene. Factors such as family history and primiparity were associated to the risk of developing pre-eclampsia. |
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Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsiaPre-eclampsiaTransforming Growth FactorsGenetic polymorphismAbstract Objectives: to verify the contribution of polymorphisms rs1800469 and rs1800468 of the TGF-β1 gene and the risk factors for the pre-eclampsia development. Methods: this is a case-control study with 257 women from the Uberaba region of Minas Gerais were selected, 88 of them were in the pre-eclampsia group and 169 in the control group. Genotyping was performed by allelic discrimination using the real-time PCR technique. The odds ratio and the 95% confidence interval were used to evaluate the probability of the polymorphisms studied contributing for the pre-eclampsia development. The logistic regression analysis was performed to evaluate the relation among family recurrence, smoking, primiparity and the presence of polymorphic alleles and susceptibility of preeclampsia. Results: no association was found between polymorphisms rs1800469 and rs1800468 of the TGF-β1 gene and pre-eclampsia. The logistic regression analysis was statistically significant for family recurrence, showing that women with a family history of pre-eclampsia and primiparity are at an increased risk of developing the disease. Conclusions: no association was found between polymorphisms rs1800469 and rs1800468 of the TGF-β1 and pre-eclampsia gene. Factors such as family history and primiparity were associated to the risk of developing pre-eclampsia.Instituto de Medicina Integral Prof. Fernando Figueira2018-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292018000100179Revista Brasileira de Saúde Materno Infantil v.18 n.1 2018reponame:Revista Brasileira de Saúde Materno Infantil (Online)instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)instacron:IMIPFF10.1590/1806-93042018000100009info:eu-repo/semantics/openAccessHortolani,Andrezza Cristina CancianTanaka,Sarah Cristina Sato VazPaschoini,Marina CarvalhoBalarin,Marly Aparecida Spadottoeng2018-10-16T00:00:00Zoai:scielo:S1519-38292018000100179Revistahttp://www.scielo.br/rbsmihttps://old.scielo.br/oai/scielo-oai.php||revista@imip.org.br1806-93041519-3829opendoar:2018-10-16T00:00Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF)false |
dc.title.none.fl_str_mv |
Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia |
title |
Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia |
spellingShingle |
Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia Hortolani,Andrezza Cristina Cancian Pre-eclampsia Transforming Growth Factors Genetic polymorphism |
title_short |
Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia |
title_full |
Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia |
title_fullStr |
Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia |
title_full_unstemmed |
Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia |
title_sort |
Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia |
author |
Hortolani,Andrezza Cristina Cancian |
author_facet |
Hortolani,Andrezza Cristina Cancian Tanaka,Sarah Cristina Sato Vaz Paschoini,Marina Carvalho Balarin,Marly Aparecida Spadotto |
author_role |
author |
author2 |
Tanaka,Sarah Cristina Sato Vaz Paschoini,Marina Carvalho Balarin,Marly Aparecida Spadotto |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Hortolani,Andrezza Cristina Cancian Tanaka,Sarah Cristina Sato Vaz Paschoini,Marina Carvalho Balarin,Marly Aparecida Spadotto |
dc.subject.por.fl_str_mv |
Pre-eclampsia Transforming Growth Factors Genetic polymorphism |
topic |
Pre-eclampsia Transforming Growth Factors Genetic polymorphism |
description |
Abstract Objectives: to verify the contribution of polymorphisms rs1800469 and rs1800468 of the TGF-β1 gene and the risk factors for the pre-eclampsia development. Methods: this is a case-control study with 257 women from the Uberaba region of Minas Gerais were selected, 88 of them were in the pre-eclampsia group and 169 in the control group. Genotyping was performed by allelic discrimination using the real-time PCR technique. The odds ratio and the 95% confidence interval were used to evaluate the probability of the polymorphisms studied contributing for the pre-eclampsia development. The logistic regression analysis was performed to evaluate the relation among family recurrence, smoking, primiparity and the presence of polymorphic alleles and susceptibility of preeclampsia. Results: no association was found between polymorphisms rs1800469 and rs1800468 of the TGF-β1 gene and pre-eclampsia. The logistic regression analysis was statistically significant for family recurrence, showing that women with a family history of pre-eclampsia and primiparity are at an increased risk of developing the disease. Conclusions: no association was found between polymorphisms rs1800469 and rs1800468 of the TGF-β1 and pre-eclampsia gene. Factors such as family history and primiparity were associated to the risk of developing pre-eclampsia. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292018000100179 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292018000100179 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-93042018000100009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Medicina Integral Prof. Fernando Figueira |
publisher.none.fl_str_mv |
Instituto de Medicina Integral Prof. Fernando Figueira |
dc.source.none.fl_str_mv |
Revista Brasileira de Saúde Materno Infantil v.18 n.1 2018 reponame:Revista Brasileira de Saúde Materno Infantil (Online) instname:Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) instacron:IMIPFF |
instname_str |
Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) |
instacron_str |
IMIPFF |
institution |
IMIPFF |
reponame_str |
Revista Brasileira de Saúde Materno Infantil (Online) |
collection |
Revista Brasileira de Saúde Materno Infantil (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Saúde Materno Infantil (Online) - Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) |
repository.mail.fl_str_mv |
||revista@imip.org.br |
_version_ |
1752129929896525824 |