THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans

Detalhes bibliográficos
Autor(a) principal: Mauch, Renan Marrichi
Data de Publicação: 2013
Outros Autores: Cunha, Vinícius de Oliveira, Dias, Amanda Latercia Tranches
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/53551
Resumo: Melanin is a pigment produced by laccase, a phenoloxydase enzyme, and is related to the virulence of Cryptococcus neoformans as it is also considered an adaption mechanism to environmental conditions and protection against UV radiation, phagocytic system attack and antifungal drugs. Laccase synthesis is stimulated by several factors, including copper metabolism. The current study shows C. neoformans strains with higher melanization intensity when grown in L-dopa medium supplemented with different concentrations of copper sulfate. This increase shows that melanization rates may be enhanced in the presence of copper ions and may also enhance the virulence of C. neoformans in infected patients that present increasing copper concentrations in serum, such as those with HIV. The virulence of these strains may also be increased in the environment, where this metal is available as CuSO4 in algicidal and fungicidal compounds.
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spelling THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformansA interferência de cobre na melanogênese de Cryptococcus neoformansCryptococcus neoformansMelaninCopperVirulenceMelanin is a pigment produced by laccase, a phenoloxydase enzyme, and is related to the virulence of Cryptococcus neoformans as it is also considered an adaption mechanism to environmental conditions and protection against UV radiation, phagocytic system attack and antifungal drugs. Laccase synthesis is stimulated by several factors, including copper metabolism. The current study shows C. neoformans strains with higher melanization intensity when grown in L-dopa medium supplemented with different concentrations of copper sulfate. This increase shows that melanization rates may be enhanced in the presence of copper ions and may also enhance the virulence of C. neoformans in infected patients that present increasing copper concentrations in serum, such as those with HIV. The virulence of these strains may also be increased in the environment, where this metal is available as CuSO4 in algicidal and fungicidal compounds.A melanina é um pigmento produzido pela enzima lacase, uma fenoloxidase, e está associada à virulência de Cryptococcus neoformans sendo considerada mecanismo de adaptação às condições ambientais e proteção contra a radiação UV, ataque do sistema fagocítico e antifúngicos. A lacase tem sua síntese estimulada por diversos fatores, incluindo o metabolismo de cobre. Este estudo mostra linhagens de C. neoformans com maior intensidade de melanização quando cultivadas em meio L-dopa suplementado com diferentes concentrações de sulfato de cobre. Este aumento demonstra que as taxas de melanização podem ser aumentadas na presença de íons cobre e também aumentar a virulência de C. neoformans em pacientes infectados que apresentam aumento nas concentrações séricas de íons cobre tais como pacientes com HIV. A virulência destas linhagens também pode ser incrementada no meio ambiente, onde este metal está disponível como CuSO4 em compostos algicidas e fungicidas.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/53551Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 No. 2 (2013); 117-120Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 Núm. 2 (2013); 117-120Revista do Instituto de Medicina Tropical de São Paulo; v. 55 n. 2 (2013); 117-1201678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/53551/77134Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMauch, Renan MarrichiCunha, Vinícius de OliveiraDias, Amanda Latercia Tranches2014-01-30T12:25:40Zoai:revistas.usp.br:article/53551Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:12.482031Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
A interferência de cobre na melanogênese de Cryptococcus neoformans
title THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
spellingShingle THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
Mauch, Renan Marrichi
Cryptococcus neoformans
Melanin
Copper
Virulence
title_short THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
title_full THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
title_fullStr THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
title_full_unstemmed THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
title_sort THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
author Mauch, Renan Marrichi
author_facet Mauch, Renan Marrichi
Cunha, Vinícius de Oliveira
Dias, Amanda Latercia Tranches
author_role author
author2 Cunha, Vinícius de Oliveira
Dias, Amanda Latercia Tranches
author2_role author
author
dc.contributor.author.fl_str_mv Mauch, Renan Marrichi
Cunha, Vinícius de Oliveira
Dias, Amanda Latercia Tranches
dc.subject.por.fl_str_mv Cryptococcus neoformans
Melanin
Copper
Virulence
topic Cryptococcus neoformans
Melanin
Copper
Virulence
description Melanin is a pigment produced by laccase, a phenoloxydase enzyme, and is related to the virulence of Cryptococcus neoformans as it is also considered an adaption mechanism to environmental conditions and protection against UV radiation, phagocytic system attack and antifungal drugs. Laccase synthesis is stimulated by several factors, including copper metabolism. The current study shows C. neoformans strains with higher melanization intensity when grown in L-dopa medium supplemented with different concentrations of copper sulfate. This increase shows that melanization rates may be enhanced in the presence of copper ions and may also enhance the virulence of C. neoformans in infected patients that present increasing copper concentrations in serum, such as those with HIV. The virulence of these strains may also be increased in the environment, where this metal is available as CuSO4 in algicidal and fungicidal compounds.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/53551
url https://www.revistas.usp.br/rimtsp/article/view/53551
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/53551/77134
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 No. 2 (2013); 117-120
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 Núm. 2 (2013); 117-120
Revista do Instituto de Medicina Tropical de São Paulo; v. 55 n. 2 (2013); 117-120
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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