THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/53551 |
Resumo: | Melanin is a pigment produced by laccase, a phenoloxydase enzyme, and is related to the virulence of Cryptococcus neoformans as it is also considered an adaption mechanism to environmental conditions and protection against UV radiation, phagocytic system attack and antifungal drugs. Laccase synthesis is stimulated by several factors, including copper metabolism. The current study shows C. neoformans strains with higher melanization intensity when grown in L-dopa medium supplemented with different concentrations of copper sulfate. This increase shows that melanization rates may be enhanced in the presence of copper ions and may also enhance the virulence of C. neoformans in infected patients that present increasing copper concentrations in serum, such as those with HIV. The virulence of these strains may also be increased in the environment, where this metal is available as CuSO4 in algicidal and fungicidal compounds. |
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THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformansA interferência de cobre na melanogênese de Cryptococcus neoformansCryptococcus neoformansMelaninCopperVirulenceMelanin is a pigment produced by laccase, a phenoloxydase enzyme, and is related to the virulence of Cryptococcus neoformans as it is also considered an adaption mechanism to environmental conditions and protection against UV radiation, phagocytic system attack and antifungal drugs. Laccase synthesis is stimulated by several factors, including copper metabolism. The current study shows C. neoformans strains with higher melanization intensity when grown in L-dopa medium supplemented with different concentrations of copper sulfate. This increase shows that melanization rates may be enhanced in the presence of copper ions and may also enhance the virulence of C. neoformans in infected patients that present increasing copper concentrations in serum, such as those with HIV. The virulence of these strains may also be increased in the environment, where this metal is available as CuSO4 in algicidal and fungicidal compounds.A melanina é um pigmento produzido pela enzima lacase, uma fenoloxidase, e está associada à virulência de Cryptococcus neoformans sendo considerada mecanismo de adaptação às condições ambientais e proteção contra a radiação UV, ataque do sistema fagocítico e antifúngicos. A lacase tem sua síntese estimulada por diversos fatores, incluindo o metabolismo de cobre. Este estudo mostra linhagens de C. neoformans com maior intensidade de melanização quando cultivadas em meio L-dopa suplementado com diferentes concentrações de sulfato de cobre. Este aumento demonstra que as taxas de melanização podem ser aumentadas na presença de íons cobre e também aumentar a virulência de C. neoformans em pacientes infectados que apresentam aumento nas concentrações séricas de íons cobre tais como pacientes com HIV. A virulência destas linhagens também pode ser incrementada no meio ambiente, onde este metal está disponível como CuSO4 em compostos algicidas e fungicidas.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/53551Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 No. 2 (2013); 117-120Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 Núm. 2 (2013); 117-120Revista do Instituto de Medicina Tropical de São Paulo; v. 55 n. 2 (2013); 117-1201678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/53551/77134Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMauch, Renan MarrichiCunha, Vinícius de OliveiraDias, Amanda Latercia Tranches2014-01-30T12:25:40Zoai:revistas.usp.br:article/53551Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:12.482031Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans A interferência de cobre na melanogênese de Cryptococcus neoformans |
title |
THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans |
spellingShingle |
THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans Mauch, Renan Marrichi Cryptococcus neoformans Melanin Copper Virulence |
title_short |
THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans |
title_full |
THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans |
title_fullStr |
THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans |
title_full_unstemmed |
THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans |
title_sort |
THE COPPER INTERFERENCE WITH THE MELANOGENESIS OF Cryptococcus neoformans |
author |
Mauch, Renan Marrichi |
author_facet |
Mauch, Renan Marrichi Cunha, Vinícius de Oliveira Dias, Amanda Latercia Tranches |
author_role |
author |
author2 |
Cunha, Vinícius de Oliveira Dias, Amanda Latercia Tranches |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Mauch, Renan Marrichi Cunha, Vinícius de Oliveira Dias, Amanda Latercia Tranches |
dc.subject.por.fl_str_mv |
Cryptococcus neoformans Melanin Copper Virulence |
topic |
Cryptococcus neoformans Melanin Copper Virulence |
description |
Melanin is a pigment produced by laccase, a phenoloxydase enzyme, and is related to the virulence of Cryptococcus neoformans as it is also considered an adaption mechanism to environmental conditions and protection against UV radiation, phagocytic system attack and antifungal drugs. Laccase synthesis is stimulated by several factors, including copper metabolism. The current study shows C. neoformans strains with higher melanization intensity when grown in L-dopa medium supplemented with different concentrations of copper sulfate. This increase shows that melanization rates may be enhanced in the presence of copper ions and may also enhance the virulence of C. neoformans in infected patients that present increasing copper concentrations in serum, such as those with HIV. The virulence of these strains may also be increased in the environment, where this metal is available as CuSO4 in algicidal and fungicidal compounds. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/53551 |
url |
https://www.revistas.usp.br/rimtsp/article/view/53551 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/53551/77134 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 No. 2 (2013); 117-120 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 Núm. 2 (2013); 117-120 Revista do Instituto de Medicina Tropical de São Paulo; v. 55 n. 2 (2013); 117-120 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951648590036992 |