High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/210963 |
Resumo: | Children have an increased likelihood of becoming carriers of the chronic hepatitis B virus. A total of 1,381 children and adolescents were assessed in five municipalities of Maranhao State, Brazil, for detection of anti-HBc, HBsAg and anti-HBs serologic markers and sociodemographic and behavioral features. Among those who were HBsAg negative and anti-HBc negative, the proportion of anti-HBs positives was calculated after the individuals had completed the vaccination schedule. The robust variance of the Poisson’s regression model was used in order to have adjusted tables and calculate the prevalence ratio. Multivariate analysis was performed to identify the factors associated with the prevalence of anti-HBc with or without HBsAg and the vaccine response. It was observed that 163 children were anti-HBc positive and nine individuals were HBsAg positive. The factors associated with the infection were: municipality of residence (residing in Morros municipality or Humberto de Campos municipality), residence in a rural area, aged between 13 and 15 years old, and illicit drug use. The percentage of individuals who were anti-HBc negative and received all three doses of the vaccine was 48.5%. Among these, only 276 (38.9%) had antibodies at protective concentrations. In an adjusted analysis, Morros municipality presented an increased positivity of vaccine response (p < 0.001), and the age ranging between 6 and 10 years old presented a reduced frequency of response. This study reveals a high prevalence of current and past HBV infection within the targeted age group which, in addition to the low vaccination coverage and serological responses, raises concerns about the management of prevention measures, especially the quality of vaccination in these locations. |
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High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern BrazilPrevalenceHepatitis BVaccine responseChildrenChildren have an increased likelihood of becoming carriers of the chronic hepatitis B virus. A total of 1,381 children and adolescents were assessed in five municipalities of Maranhao State, Brazil, for detection of anti-HBc, HBsAg and anti-HBs serologic markers and sociodemographic and behavioral features. Among those who were HBsAg negative and anti-HBc negative, the proportion of anti-HBs positives was calculated after the individuals had completed the vaccination schedule. The robust variance of the Poisson’s regression model was used in order to have adjusted tables and calculate the prevalence ratio. Multivariate analysis was performed to identify the factors associated with the prevalence of anti-HBc with or without HBsAg and the vaccine response. It was observed that 163 children were anti-HBc positive and nine individuals were HBsAg positive. The factors associated with the infection were: municipality of residence (residing in Morros municipality or Humberto de Campos municipality), residence in a rural area, aged between 13 and 15 years old, and illicit drug use. The percentage of individuals who were anti-HBc negative and received all three doses of the vaccine was 48.5%. Among these, only 276 (38.9%) had antibodies at protective concentrations. In an adjusted analysis, Morros municipality presented an increased positivity of vaccine response (p < 0.001), and the age ranging between 6 and 10 years old presented a reduced frequency of response. This study reveals a high prevalence of current and past HBV infection within the targeted age group which, in addition to the low vaccination coverage and serological responses, raises concerns about the management of prevention measures, especially the quality of vaccination in these locations.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2023-04-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/21096310.1590/S1678-9946202365033Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e33Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e33Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e331678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/210963/193332Copyright (c) 2023 Rogério Soares Castro, Bárbara Silva Cordeiro, Marco Aurélio Ferreira Rolim, Alessandra Porto de Macedo Costa, Max Diego Cruz Santos, Marcos Antonio Custódio Neto da Silva, Ingrid de Campos Albuquerque, Lena Maria Barros Fonseca, João Renato Rebello Pinho, Michelle Soares Gomes Gouvêa, Antônio Augusto Moura da Silva, Adalgisa de Souza Paiva Ferreirahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCastro, Rogério Soares Cordeiro, Bárbara Silva Rolim, Marco Aurélio Ferreira Costa, Alessandra Porto de Macedo Santos, Max Diego Cruz Silva, Marcos Antonio Custódio Neto da Albuquerque, Ingrid de Campos Fonseca, Lena Maria BarrosPinho, João Renato Rebello Gouvêa, Michelle Soares Gomes Silva, Antônio Augusto Moura da Ferreira, Adalgisa de Souza Paiva 2023-12-22T12:47:01Zoai:revistas.usp.br:article/210963Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2023-12-22T12:47:01Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false |
dc.title.none.fl_str_mv |
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil |
title |
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil |
spellingShingle |
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil Castro, Rogério Soares Prevalence Hepatitis B Vaccine response Children |
title_short |
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil |
title_full |
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil |
title_fullStr |
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil |
title_full_unstemmed |
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil |
title_sort |
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil |
author |
Castro, Rogério Soares |
author_facet |
Castro, Rogério Soares Cordeiro, Bárbara Silva Rolim, Marco Aurélio Ferreira Costa, Alessandra Porto de Macedo Santos, Max Diego Cruz Silva, Marcos Antonio Custódio Neto da Albuquerque, Ingrid de Campos Fonseca, Lena Maria Barros Pinho, João Renato Rebello Gouvêa, Michelle Soares Gomes Silva, Antônio Augusto Moura da Ferreira, Adalgisa de Souza Paiva |
author_role |
author |
author2 |
Cordeiro, Bárbara Silva Rolim, Marco Aurélio Ferreira Costa, Alessandra Porto de Macedo Santos, Max Diego Cruz Silva, Marcos Antonio Custódio Neto da Albuquerque, Ingrid de Campos Fonseca, Lena Maria Barros Pinho, João Renato Rebello Gouvêa, Michelle Soares Gomes Silva, Antônio Augusto Moura da Ferreira, Adalgisa de Souza Paiva |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Castro, Rogério Soares Cordeiro, Bárbara Silva Rolim, Marco Aurélio Ferreira Costa, Alessandra Porto de Macedo Santos, Max Diego Cruz Silva, Marcos Antonio Custódio Neto da Albuquerque, Ingrid de Campos Fonseca, Lena Maria Barros Pinho, João Renato Rebello Gouvêa, Michelle Soares Gomes Silva, Antônio Augusto Moura da Ferreira, Adalgisa de Souza Paiva |
dc.subject.por.fl_str_mv |
Prevalence Hepatitis B Vaccine response Children |
topic |
Prevalence Hepatitis B Vaccine response Children |
description |
Children have an increased likelihood of becoming carriers of the chronic hepatitis B virus. A total of 1,381 children and adolescents were assessed in five municipalities of Maranhao State, Brazil, for detection of anti-HBc, HBsAg and anti-HBs serologic markers and sociodemographic and behavioral features. Among those who were HBsAg negative and anti-HBc negative, the proportion of anti-HBs positives was calculated after the individuals had completed the vaccination schedule. The robust variance of the Poisson’s regression model was used in order to have adjusted tables and calculate the prevalence ratio. Multivariate analysis was performed to identify the factors associated with the prevalence of anti-HBc with or without HBsAg and the vaccine response. It was observed that 163 children were anti-HBc positive and nine individuals were HBsAg positive. The factors associated with the infection were: municipality of residence (residing in Morros municipality or Humberto de Campos municipality), residence in a rural area, aged between 13 and 15 years old, and illicit drug use. The percentage of individuals who were anti-HBc negative and received all three doses of the vaccine was 48.5%. Among these, only 276 (38.9%) had antibodies at protective concentrations. In an adjusted analysis, Morros municipality presented an increased positivity of vaccine response (p < 0.001), and the age ranging between 6 and 10 years old presented a reduced frequency of response. This study reveals a high prevalence of current and past HBV infection within the targeted age group which, in addition to the low vaccination coverage and serological responses, raises concerns about the management of prevention measures, especially the quality of vaccination in these locations. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/210963 10.1590/S1678-9946202365033 |
url |
https://www.revistas.usp.br/rimtsp/article/view/210963 |
identifier_str_mv |
10.1590/S1678-9946202365033 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/210963/193332 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e33 Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e33 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e33 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
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||revimtsp@usp.br |
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1798951636582793216 |