High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Castro, Rogério Soares
Data de Publicação: 2023
Outros Autores: Cordeiro, Bárbara Silva, Rolim, Marco Aurélio Ferreira, Costa, Alessandra Porto de Macedo, Santos, Max Diego Cruz, Silva, Marcos Antonio Custódio Neto da, Albuquerque, Ingrid de Campos, Fonseca, Lena Maria Barros, Pinho, João Renato Rebello, Gouvêa, Michelle Soares Gomes, Silva, Antônio Augusto Moura da, Ferreira, Adalgisa de Souza Paiva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/210963
Resumo: Children have an increased likelihood of becoming carriers of the chronic hepatitis B virus. A total of 1,381 children and adolescents were assessed in five municipalities of Maranhao State, Brazil, for detection of anti-HBc, HBsAg and anti-HBs serologic markers and sociodemographic and behavioral features. Among those who were HBsAg negative and anti-HBc negative, the proportion of anti-HBs positives was calculated after the individuals had completed the vaccination schedule. The robust variance of the Poisson’s regression model was used in order to have adjusted tables and calculate the prevalence ratio. Multivariate analysis was performed to identify the factors associated with the prevalence of anti-HBc with or without HBsAg and the vaccine response. It was observed that 163 children were anti-HBc positive and nine individuals were HBsAg positive. The factors associated with the infection were: municipality of residence (residing in Morros municipality or Humberto de Campos municipality), residence in a rural area, aged between 13 and 15 years old, and illicit drug use. The percentage of individuals who were anti-HBc negative and received all three doses of the vaccine was 48.5%. Among these, only 276 (38.9%) had antibodies at protective concentrations. In an adjusted analysis, Morros municipality presented an increased positivity of vaccine response (p < 0.001), and the age ranging between 6 and 10 years old presented a reduced frequency of response. This study reveals a high prevalence of current and past HBV infection within the targeted age group which, in addition to the low vaccination coverage and serological responses, raises concerns about the management of prevention measures, especially the quality of vaccination in these locations.
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spelling High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern BrazilPrevalenceHepatitis BVaccine responseChildrenChildren have an increased likelihood of becoming carriers of the chronic hepatitis B virus. A total of 1,381 children and adolescents were assessed in five municipalities of Maranhao State, Brazil, for detection of anti-HBc, HBsAg and anti-HBs serologic markers and sociodemographic and behavioral features. Among those who were HBsAg negative and anti-HBc negative, the proportion of anti-HBs positives was calculated after the individuals had completed the vaccination schedule. The robust variance of the Poisson’s regression model was used in order to have adjusted tables and calculate the prevalence ratio. Multivariate analysis was performed to identify the factors associated with the prevalence of anti-HBc with or without HBsAg and the vaccine response. It was observed that 163 children were anti-HBc positive and nine individuals were HBsAg positive. The factors associated with the infection were: municipality of residence (residing in Morros municipality or Humberto de Campos municipality), residence in a rural area, aged between 13 and 15 years old, and illicit drug use. The percentage of individuals who were anti-HBc negative and received all three doses of the vaccine was 48.5%. Among these, only 276 (38.9%) had antibodies at protective concentrations. In an adjusted analysis, Morros municipality presented an increased positivity of vaccine response (p < 0.001), and the age ranging between 6 and 10 years old presented a reduced frequency of response. This study reveals a high prevalence of current and past HBV infection within the targeted age group which, in addition to the low vaccination coverage and serological responses, raises concerns about the management of prevention measures, especially the quality of vaccination in these locations.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2023-04-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/21096310.1590/S1678-9946202365033Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e33Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e33Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e331678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/210963/193332Copyright (c) 2023 Rogério Soares Castro, Bárbara Silva Cordeiro, Marco Aurélio Ferreira Rolim, Alessandra Porto de Macedo Costa, Max Diego Cruz Santos, Marcos Antonio Custódio Neto da Silva, Ingrid de Campos Albuquerque, Lena Maria Barros Fonseca, João Renato Rebello Pinho, Michelle Soares Gomes Gouvêa, Antônio Augusto Moura da Silva, Adalgisa de Souza Paiva Ferreirahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCastro, Rogério Soares Cordeiro, Bárbara Silva Rolim, Marco Aurélio Ferreira Costa, Alessandra Porto de Macedo Santos, Max Diego Cruz Silva, Marcos Antonio Custódio Neto da Albuquerque, Ingrid de Campos Fonseca, Lena Maria BarrosPinho, João Renato Rebello Gouvêa, Michelle Soares Gomes Silva, Antônio Augusto Moura da Ferreira, Adalgisa de Souza Paiva 2023-12-22T12:47:01Zoai:revistas.usp.br:article/210963Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2023-12-22T12:47:01Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false
dc.title.none.fl_str_mv High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
title High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
spellingShingle High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
Castro, Rogério Soares
Prevalence
Hepatitis B
Vaccine response
Children
title_short High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
title_full High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
title_fullStr High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
title_full_unstemmed High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
title_sort High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
author Castro, Rogério Soares
author_facet Castro, Rogério Soares
Cordeiro, Bárbara Silva
Rolim, Marco Aurélio Ferreira
Costa, Alessandra Porto de Macedo
Santos, Max Diego Cruz
Silva, Marcos Antonio Custódio Neto da
Albuquerque, Ingrid de Campos
Fonseca, Lena Maria Barros
Pinho, João Renato Rebello
Gouvêa, Michelle Soares Gomes
Silva, Antônio Augusto Moura da
Ferreira, Adalgisa de Souza Paiva
author_role author
author2 Cordeiro, Bárbara Silva
Rolim, Marco Aurélio Ferreira
Costa, Alessandra Porto de Macedo
Santos, Max Diego Cruz
Silva, Marcos Antonio Custódio Neto da
Albuquerque, Ingrid de Campos
Fonseca, Lena Maria Barros
Pinho, João Renato Rebello
Gouvêa, Michelle Soares Gomes
Silva, Antônio Augusto Moura da
Ferreira, Adalgisa de Souza Paiva
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Rogério Soares
Cordeiro, Bárbara Silva
Rolim, Marco Aurélio Ferreira
Costa, Alessandra Porto de Macedo
Santos, Max Diego Cruz
Silva, Marcos Antonio Custódio Neto da
Albuquerque, Ingrid de Campos
Fonseca, Lena Maria Barros
Pinho, João Renato Rebello
Gouvêa, Michelle Soares Gomes
Silva, Antônio Augusto Moura da
Ferreira, Adalgisa de Souza Paiva
dc.subject.por.fl_str_mv Prevalence
Hepatitis B
Vaccine response
Children
topic Prevalence
Hepatitis B
Vaccine response
Children
description Children have an increased likelihood of becoming carriers of the chronic hepatitis B virus. A total of 1,381 children and adolescents were assessed in five municipalities of Maranhao State, Brazil, for detection of anti-HBc, HBsAg and anti-HBs serologic markers and sociodemographic and behavioral features. Among those who were HBsAg negative and anti-HBc negative, the proportion of anti-HBs positives was calculated after the individuals had completed the vaccination schedule. The robust variance of the Poisson’s regression model was used in order to have adjusted tables and calculate the prevalence ratio. Multivariate analysis was performed to identify the factors associated with the prevalence of anti-HBc with or without HBsAg and the vaccine response. It was observed that 163 children were anti-HBc positive and nine individuals were HBsAg positive. The factors associated with the infection were: municipality of residence (residing in Morros municipality or Humberto de Campos municipality), residence in a rural area, aged between 13 and 15 years old, and illicit drug use. The percentage of individuals who were anti-HBc negative and received all three doses of the vaccine was 48.5%. Among these, only 276 (38.9%) had antibodies at protective concentrations. In an adjusted analysis, Morros municipality presented an increased positivity of vaccine response (p < 0.001), and the age ranging between 6 and 10 years old presented a reduced frequency of response. This study reveals a high prevalence of current and past HBV infection within the targeted age group which, in addition to the low vaccination coverage and serological responses, raises concerns about the management of prevention measures, especially the quality of vaccination in these locations.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-24
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/210963
10.1590/S1678-9946202365033
url https://www.revistas.usp.br/rimtsp/article/view/210963
identifier_str_mv 10.1590/S1678-9946202365033
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/210963/193332
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e33
Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e33
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e33
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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