Brazilian hepatitis B vaccine: a six-year follow-up in adolescents

Detalhes bibliográficos
Autor(a) principal: Alexandre,Kamilla Vêncio Frauzino
Data de Publicação: 2012
Outros Autores: Martins,Regina Maria Bringel, Souza,Márcia Maria de, Rodrigues,Isolina Maria Xavier, Teles,Sheila Araujo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000800016
Resumo: The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (&gt; 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.
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spelling Brazilian hepatitis B vaccine: a six-year follow-up in adolescentshepatitis B vaccineadolescentsfollow-upThe protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (&gt; 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.Instituto Oswaldo Cruz, Ministério da Saúde2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000800016Memórias do Instituto Oswaldo Cruz v.107 n.8 2012reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762012000800016info:eu-repo/semantics/openAccessAlexandre,Kamilla Vêncio FrauzinoMartins,Regina Maria BringelSouza,Márcia Maria deRodrigues,Isolina Maria XavierTeles,Sheila Araujoeng2020-04-25T17:51:18Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:39.801Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
title Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
spellingShingle Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
Alexandre,Kamilla Vêncio Frauzino
hepatitis B vaccine
adolescents
follow-up
title_short Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
title_full Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
title_fullStr Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
title_full_unstemmed Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
title_sort Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
author Alexandre,Kamilla Vêncio Frauzino
author_facet Alexandre,Kamilla Vêncio Frauzino
Martins,Regina Maria Bringel
Souza,Márcia Maria de
Rodrigues,Isolina Maria Xavier
Teles,Sheila Araujo
author_role author
author2 Martins,Regina Maria Bringel
Souza,Márcia Maria de
Rodrigues,Isolina Maria Xavier
Teles,Sheila Araujo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Alexandre,Kamilla Vêncio Frauzino
Martins,Regina Maria Bringel
Souza,Márcia Maria de
Rodrigues,Isolina Maria Xavier
Teles,Sheila Araujo
dc.subject.por.fl_str_mv hepatitis B vaccine
adolescents
follow-up
topic hepatitis B vaccine
adolescents
follow-up
dc.description.none.fl_txt_mv The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (&gt; 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.
description The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (&gt; 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000800016
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000800016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762012000800016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.107 n.8 2012
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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