Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study

Detalhes bibliográficos
Autor(a) principal: Machado, Clarisse Martins
Data de Publicação: 1991
Outros Autores: Fink, Maria Cristina D. S., Vilas Boas, Lucy S., Sumita, Laura Massami, Weinberg, Adriana, Shiguematsu, Kenji, Souza, Ibiracy C., Casanova, Lucy D., Pannuti, Cláudio Sérgio
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28809
Resumo: In order to demonstrate the occurrence of CMV perinatal infection in a middle socioeconomic class population, the authors conducted a 8-month prospective study in 37 children, not infected congenitally, born in a public hospital of São Paulo city, Prevalence of CMV-IgG antibodies in mothers, detected by immunoenzimatic assay (ELISA), was 92.7%. Survival analysis showed that the risk of acquiring CMV perinatal infection diagnosed by virus isolation in human fibroblasts was 30.9%. When the diagnostic method was detection of IgM class antibodies by indirect immunofluorescence the risk was 8.1% (p < 0.05). Milk samples inoculated in human fibroblasts failed to demonstrate the presence of virus. The infected children did not present any signal of disease in a 4-month follow-up.
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spelling Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study Infecção perinatal pelo citomegalovírus em hospital público de São Paulo: estudo prospectivo CMVInfecção perinatal In order to demonstrate the occurrence of CMV perinatal infection in a middle socioeconomic class population, the authors conducted a 8-month prospective study in 37 children, not infected congenitally, born in a public hospital of São Paulo city, Prevalence of CMV-IgG antibodies in mothers, detected by immunoenzimatic assay (ELISA), was 92.7%. Survival analysis showed that the risk of acquiring CMV perinatal infection diagnosed by virus isolation in human fibroblasts was 30.9%. When the diagnostic method was detection of IgM class antibodies by indirect immunofluorescence the risk was 8.1% (p < 0.05). Milk samples inoculated in human fibroblasts failed to demonstrate the presence of virus. The infected children did not present any signal of disease in a 4-month follow-up. Com o objetivo de se avaliar a magnitude da infecção perinatal pelo citomegalovírus em hospital público do município de São Paulo, os autores acompanharam prospectivamente 98 recém-nascidos até o quarto mês de vida. Amostras de urina foram coletadas ao nascimento e posteriormente a cada mês, para inoculação em tubos contendo fibroblastos humanos. Amostras de sangue foram coletadas ao nascimento, no segundo e quarto mês de vida para pesquisa de anticorpos IgM específicos para o CMV, pelo método de imunofluorescência indireta. Dos 37 recém-nascidos que foram acompanhados até o quarto mês de vida, 9 se infectaram neste período, com diagnóstico feito pelo isolamento do CMV. O risco de aquisição da infecção pelo citomegalovírus no período perinatal estimado pela tábua de sobrevivência foi de 30,9%. A pesquisa de anticorpos IgM por imunofluorescência indireta só permitiu tal diagnóstico em 2 casos (8,1%). A diferença observada entre os dois métodos foi estatisticamente significante (p = 0,015). O estudo da prevalência de anticorpos IgG pelo ensaio imunoenzimático nas mães das crianças mostrou taxas de 92,7%. Não se isolou CMV nas amostras de leite materno, coletadas mensalmente até o terceiro mês de lactação. O acompanhamento clínico evidenciou que as crianças infectadas apresentaram-se de forma assintomática e com desenvolvimento neurop-sicomotor normal até o quarto mês. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1991-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28809Revista do Instituto de Medicina Tropical de São Paulo; Vol. 33 No. 2 (1991); 159-166 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 33 Núm. 2 (1991); 159-166 Revista do Instituto de Medicina Tropical de São Paulo; v. 33 n. 2 (1991); 159-166 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28809/30662Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMachado, Clarisse MartinsFink, Maria Cristina D. S.Vilas Boas, Lucy S.Sumita, Laura MassamiWeinberg, AdrianaShiguematsu, KenjiSouza, Ibiracy C.Casanova, Lucy D.Pannuti, Cláudio Sérgio2012-07-02T01:30:15Zoai:revistas.usp.br:article/28809Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:34.309182Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study
Infecção perinatal pelo citomegalovírus em hospital público de São Paulo: estudo prospectivo
title Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study
spellingShingle Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study
Machado, Clarisse Martins
CMV
Infecção perinatal
title_short Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study
title_full Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study
title_fullStr Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study
title_full_unstemmed Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study
title_sort Cytomegalovirus perinatal infection in a public hospital of São Paulo city: a prospective study
author Machado, Clarisse Martins
author_facet Machado, Clarisse Martins
Fink, Maria Cristina D. S.
Vilas Boas, Lucy S.
Sumita, Laura Massami
Weinberg, Adriana
Shiguematsu, Kenji
Souza, Ibiracy C.
Casanova, Lucy D.
Pannuti, Cláudio Sérgio
author_role author
author2 Fink, Maria Cristina D. S.
Vilas Boas, Lucy S.
Sumita, Laura Massami
Weinberg, Adriana
Shiguematsu, Kenji
Souza, Ibiracy C.
Casanova, Lucy D.
Pannuti, Cláudio Sérgio
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Clarisse Martins
Fink, Maria Cristina D. S.
Vilas Boas, Lucy S.
Sumita, Laura Massami
Weinberg, Adriana
Shiguematsu, Kenji
Souza, Ibiracy C.
Casanova, Lucy D.
Pannuti, Cláudio Sérgio
dc.subject.por.fl_str_mv CMV
Infecção perinatal
topic CMV
Infecção perinatal
description In order to demonstrate the occurrence of CMV perinatal infection in a middle socioeconomic class population, the authors conducted a 8-month prospective study in 37 children, not infected congenitally, born in a public hospital of São Paulo city, Prevalence of CMV-IgG antibodies in mothers, detected by immunoenzimatic assay (ELISA), was 92.7%. Survival analysis showed that the risk of acquiring CMV perinatal infection diagnosed by virus isolation in human fibroblasts was 30.9%. When the diagnostic method was detection of IgM class antibodies by indirect immunofluorescence the risk was 8.1% (p < 0.05). Milk samples inoculated in human fibroblasts failed to demonstrate the presence of virus. The infected children did not present any signal of disease in a 4-month follow-up.
publishDate 1991
dc.date.none.fl_str_mv 1991-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28809
url https://www.revistas.usp.br/rimtsp/article/view/28809
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28809/30662
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 33 No. 2 (1991); 159-166
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 33 Núm. 2 (1991); 159-166
Revista do Instituto de Medicina Tropical de São Paulo; v. 33 n. 2 (1991); 159-166
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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