Variation in response of Schistosoma mansoni strains to schistosomicides

Detalhes bibliográficos
Autor(a) principal: Dias, Luiz Cândido de Souza
Data de Publicação: 1988
Outros Autores: Bruce, John I., Coles, Gerald C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28566
Resumo: The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated.
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spelling Variation in response of Schistosoma mansoni strains to schistosomicides Schistosoma mansoniExperimental chemotherapyresistance to drugs The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1988-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28566Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 2 (1988); 81-85 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 2 (1988); 81-85 Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 2 (1988); 81-85 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28566/30419Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessDias, Luiz Cândido de SouzaBruce, John I.Coles, Gerald C.2012-07-02T01:04:36Zoai:revistas.usp.br:article/28566Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:18.124871Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Variation in response of Schistosoma mansoni strains to schistosomicides
title Variation in response of Schistosoma mansoni strains to schistosomicides
spellingShingle Variation in response of Schistosoma mansoni strains to schistosomicides
Dias, Luiz Cândido de Souza
Schistosoma mansoni
Experimental chemotherapy
resistance to drugs
title_short Variation in response of Schistosoma mansoni strains to schistosomicides
title_full Variation in response of Schistosoma mansoni strains to schistosomicides
title_fullStr Variation in response of Schistosoma mansoni strains to schistosomicides
title_full_unstemmed Variation in response of Schistosoma mansoni strains to schistosomicides
title_sort Variation in response of Schistosoma mansoni strains to schistosomicides
author Dias, Luiz Cândido de Souza
author_facet Dias, Luiz Cândido de Souza
Bruce, John I.
Coles, Gerald C.
author_role author
author2 Bruce, John I.
Coles, Gerald C.
author2_role author
author
dc.contributor.author.fl_str_mv Dias, Luiz Cândido de Souza
Bruce, John I.
Coles, Gerald C.
dc.subject.por.fl_str_mv Schistosoma mansoni
Experimental chemotherapy
resistance to drugs
topic Schistosoma mansoni
Experimental chemotherapy
resistance to drugs
description The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated.
publishDate 1988
dc.date.none.fl_str_mv 1988-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28566
url https://www.revistas.usp.br/rimtsp/article/view/28566
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28566/30419
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 2 (1988); 81-85
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 2 (1988); 81-85
Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 2 (1988); 81-85
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
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reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
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