Variation in response of Schistosoma mansoni strains to schistosomicides
Autor(a) principal: | |
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Data de Publicação: | 1988 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28566 |
Resumo: | The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated. |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Variation in response of Schistosoma mansoni strains to schistosomicides Schistosoma mansoniExperimental chemotherapyresistance to drugs The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1988-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28566Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 2 (1988); 81-85 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 2 (1988); 81-85 Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 2 (1988); 81-85 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28566/30419Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessDias, Luiz Cândido de SouzaBruce, John I.Coles, Gerald C.2012-07-02T01:04:36Zoai:revistas.usp.br:article/28566Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:18.124871Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Variation in response of Schistosoma mansoni strains to schistosomicides |
title |
Variation in response of Schistosoma mansoni strains to schistosomicides |
spellingShingle |
Variation in response of Schistosoma mansoni strains to schistosomicides Dias, Luiz Cândido de Souza Schistosoma mansoni Experimental chemotherapy resistance to drugs |
title_short |
Variation in response of Schistosoma mansoni strains to schistosomicides |
title_full |
Variation in response of Schistosoma mansoni strains to schistosomicides |
title_fullStr |
Variation in response of Schistosoma mansoni strains to schistosomicides |
title_full_unstemmed |
Variation in response of Schistosoma mansoni strains to schistosomicides |
title_sort |
Variation in response of Schistosoma mansoni strains to schistosomicides |
author |
Dias, Luiz Cândido de Souza |
author_facet |
Dias, Luiz Cândido de Souza Bruce, John I. Coles, Gerald C. |
author_role |
author |
author2 |
Bruce, John I. Coles, Gerald C. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Dias, Luiz Cândido de Souza Bruce, John I. Coles, Gerald C. |
dc.subject.por.fl_str_mv |
Schistosoma mansoni Experimental chemotherapy resistance to drugs |
topic |
Schistosoma mansoni Experimental chemotherapy resistance to drugs |
description |
The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated. |
publishDate |
1988 |
dc.date.none.fl_str_mv |
1988-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28566 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28566 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28566/30419 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 2 (1988); 81-85 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 2 (1988); 81-85 Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 2 (1988); 81-85 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951637741469696 |