Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/184856 |
Resumo: | Congenital cytomegalovirus infection causes lethal diseases with neurological, visual, auditory and systemic injuries, including the hemophagocytic syndrome. Hemophagocytic lymphohistiocytosis (HLH) can be caused by primary hereditary immunological defects, as well as several infectious triggering factors, such as viruses, bacteria and fungus, among them the cytomegalovirus (CMV). Here we present the case report of a male newborn male, delivered by cesarean at term (gestation age of 39 weeks), weighing 3,250 g, with suffusion skin lesions spread throughout the body, anemia, generalized edema, hepatosplenomegaly, thrombocytopenia associated with grunts and difficulty breathing, treated with ganciclovir after receiving the diagnosis of congenital CMV infection. After a few days of hospitalization, the patient presented with high fever, persistent hepatosplenomegaly and pancytopenia, in addition to elevated ferritin and triglycerides, receiving the diagnosis of HLH treated with immunosuppressive therapy, corticosteroids and intravenous human immunoglobulin. The present case report highlights the importance for health professionals to carry out the investigation of congenital diseases, especially in developing countries, as well as their complications, such as HLH. |
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Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infectionCytomegalovirusHaemophagocytic lymphohistiocytosisImmunoglobulinCongenital cytomegalovirus infection causes lethal diseases with neurological, visual, auditory and systemic injuries, including the hemophagocytic syndrome. Hemophagocytic lymphohistiocytosis (HLH) can be caused by primary hereditary immunological defects, as well as several infectious triggering factors, such as viruses, bacteria and fungus, among them the cytomegalovirus (CMV). Here we present the case report of a male newborn male, delivered by cesarean at term (gestation age of 39 weeks), weighing 3,250 g, with suffusion skin lesions spread throughout the body, anemia, generalized edema, hepatosplenomegaly, thrombocytopenia associated with grunts and difficulty breathing, treated with ganciclovir after receiving the diagnosis of congenital CMV infection. After a few days of hospitalization, the patient presented with high fever, persistent hepatosplenomegaly and pancytopenia, in addition to elevated ferritin and triglycerides, receiving the diagnosis of HLH treated with immunosuppressive therapy, corticosteroids and intravenous human immunoglobulin. The present case report highlights the importance for health professionals to carry out the investigation of congenital diseases, especially in developing countries, as well as their complications, such as HLH.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2021-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/18485610.1590/s1678-9946202163015 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e15Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e15Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e151678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/184856/170964Copyright (c) 2021 Fabrício Silva Pessoa, Valdênia Costa Gonçalves, Eliza Maria da Costa Brito Lacerdahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessPessoa, Fabrício Silva Gonçalves, Valdênia Costa Lacerda, Eliza Maria da Costa Brito 2022-05-16T13:44:35Zoai:revistas.usp.br:article/184856Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:56.895974Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection |
title |
Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection |
spellingShingle |
Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection Pessoa, Fabrício Silva Cytomegalovirus Haemophagocytic lymphohistiocytosis Immunoglobulin |
title_short |
Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection |
title_full |
Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection |
title_fullStr |
Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection |
title_full_unstemmed |
Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection |
title_sort |
Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection |
author |
Pessoa, Fabrício Silva |
author_facet |
Pessoa, Fabrício Silva Gonçalves, Valdênia Costa Lacerda, Eliza Maria da Costa Brito |
author_role |
author |
author2 |
Gonçalves, Valdênia Costa Lacerda, Eliza Maria da Costa Brito |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Pessoa, Fabrício Silva Gonçalves, Valdênia Costa Lacerda, Eliza Maria da Costa Brito |
dc.subject.por.fl_str_mv |
Cytomegalovirus Haemophagocytic lymphohistiocytosis Immunoglobulin |
topic |
Cytomegalovirus Haemophagocytic lymphohistiocytosis Immunoglobulin |
description |
Congenital cytomegalovirus infection causes lethal diseases with neurological, visual, auditory and systemic injuries, including the hemophagocytic syndrome. Hemophagocytic lymphohistiocytosis (HLH) can be caused by primary hereditary immunological defects, as well as several infectious triggering factors, such as viruses, bacteria and fungus, among them the cytomegalovirus (CMV). Here we present the case report of a male newborn male, delivered by cesarean at term (gestation age of 39 weeks), weighing 3,250 g, with suffusion skin lesions spread throughout the body, anemia, generalized edema, hepatosplenomegaly, thrombocytopenia associated with grunts and difficulty breathing, treated with ganciclovir after receiving the diagnosis of congenital CMV infection. After a few days of hospitalization, the patient presented with high fever, persistent hepatosplenomegaly and pancytopenia, in addition to elevated ferritin and triglycerides, receiving the diagnosis of HLH treated with immunosuppressive therapy, corticosteroids and intravenous human immunoglobulin. The present case report highlights the importance for health professionals to carry out the investigation of congenital diseases, especially in developing countries, as well as their complications, such as HLH. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/184856 10.1590/s1678-9946202163015 |
url |
https://www.revistas.usp.br/rimtsp/article/view/184856 |
identifier_str_mv |
10.1590/s1678-9946202163015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/184856/170964 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e15 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e15 Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e15 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951653142953984 |