"In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986

Detalhes bibliográficos
Autor(a) principal: Santos, M. A. V.
Data de Publicação: 1987
Outros Autores: Couto, A. A., Oliveira, S. G., Rosário, V. E.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28542
Resumo: Drug resistance tests were performed with 171 strains of P. falciparum obtained from the Amazon Region, using chloroquine, mefloquine, amodiaquine and quinine. Tests lasted about 24 hours and the drug solutions were prepared just before use. Results show high percentage of resistance to chloroquine (83%) whereas nearly all strains were shown to be sensitive to mefloquine (97.7%). For both amodiaquine and quinine sensitivities were of 51.0% and 56.5% respectively. The present study demonstrates that resistance to mefloquine may be starting in Tucuruí, Pará.
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spelling "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986 Estudos "in vitro" dos níveis de resistência do Plasmodium falciparum a drogas, de 1983 a 1986 MaláriaP. falciparumResistênciaMefloquina Drug resistance tests were performed with 171 strains of P. falciparum obtained from the Amazon Region, using chloroquine, mefloquine, amodiaquine and quinine. Tests lasted about 24 hours and the drug solutions were prepared just before use. Results show high percentage of resistance to chloroquine (83%) whereas nearly all strains were shown to be sensitive to mefloquine (97.7%). For both amodiaquine and quinine sensitivities were of 51.0% and 56.5% respectively. The present study demonstrates that resistance to mefloquine may be starting in Tucuruí, Pará. Foram realizados 171 testes de sensibilidade (microtécnica) com cepas de Plasmodium falciparum da Região Amazônica brasileira para cloroquina, mefloquina, amodiaquina e quinino. Os testes tiveram duração de 24 horas com as drogas preparadas na hora da realização de cada teste. Os resultados mostraram elevada resistência a cloroquina (83%) e sensibilidade em quase a totalidade das amostras testadas para mefloquina (97,7%). Para amodiaquina e quinino observou-se sensibilidade em 51,0% e 56,5% das cepas, respectivamente. Este estudo demonstra a emergência de um possível foco de resistência do Plasmodium falciparum a mefloquina, em Tucuruí. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1987-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28542Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 6 (1987); 346-353 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 6 (1987); 346-353 Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 6 (1987); 346-353 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28542/30395Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessSantos, M. A. V.Couto, A. A.Oliveira, S. G.Rosário, V. E.2012-07-02T00:59:19Zoai:revistas.usp.br:article/28542Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:16.539379Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986
Estudos "in vitro" dos níveis de resistência do Plasmodium falciparum a drogas, de 1983 a 1986
title "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986
spellingShingle "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986
Santos, M. A. V.
Malária
P. falciparum
Resistência
Mefloquina
title_short "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986
title_full "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986
title_fullStr "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986
title_full_unstemmed "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986
title_sort "In vitro" studies on the levels of Plasmodium falciparum drug resistance from 1983 to 1986
author Santos, M. A. V.
author_facet Santos, M. A. V.
Couto, A. A.
Oliveira, S. G.
Rosário, V. E.
author_role author
author2 Couto, A. A.
Oliveira, S. G.
Rosário, V. E.
author2_role author
author
author
dc.contributor.author.fl_str_mv Santos, M. A. V.
Couto, A. A.
Oliveira, S. G.
Rosário, V. E.
dc.subject.por.fl_str_mv Malária
P. falciparum
Resistência
Mefloquina
topic Malária
P. falciparum
Resistência
Mefloquina
description Drug resistance tests were performed with 171 strains of P. falciparum obtained from the Amazon Region, using chloroquine, mefloquine, amodiaquine and quinine. Tests lasted about 24 hours and the drug solutions were prepared just before use. Results show high percentage of resistance to chloroquine (83%) whereas nearly all strains were shown to be sensitive to mefloquine (97.7%). For both amodiaquine and quinine sensitivities were of 51.0% and 56.5% respectively. The present study demonstrates that resistance to mefloquine may be starting in Tucuruí, Pará.
publishDate 1987
dc.date.none.fl_str_mv 1987-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28542
url https://www.revistas.usp.br/rimtsp/article/view/28542
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28542/30395
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 6 (1987); 346-353
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 6 (1987); 346-353
Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 6 (1987); 346-353
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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