Chronic disseminated histoplasmosis with lesions restricted to the mouth: case report

• Autor(a) principal: Valle, Antonio Carlos F. do
• Data de Publicação: 2006
• Outros Autores: Moreira, Luiz Carlos, Almeida-Paes, Rodrigo, Moreira, João S., Pizzini, Cláudia V., Muniz, Mauro de Medeiros, Zancopé-Oliveira, Rosely M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
• Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/30984
• topic: Histoplasmosis; Oral lesions; Fungal disease

We report a rare case of chronic disseminated histoplasmosis with several ulcerated lesions in the oral cavity in an alcoholic patient without human immunodeficiency virus infection, with no detectable signs and symptoms of systemic disease or extraoral manifestations. Histopathological analysis revealed chronic inflammatory process with granulomas containing Histoplasma-like organisms. The isolation of Histoplasma capsulatum provided the definitive diagnosis. Treatment with itraconazole resulted in complete remission of oral lesions. As far we aware, this is the second case report of oral histoplasmosis in an HIV negative patient described in Brazil.