"In vitro" susceptibility of Cryptococcus strains to 5 antifungal drugs

• Autor(a) principal: Bava, A. J.
• Data de Publicação: 1989
• Outros Autores: Negroni, R.
• Tipo de documento: Artigo
• Idioma: spa
• Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
• Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28687
• topic: Cryptococcus; Drogas antifúngicas; Susceptibilidad "in vitro"

A comparative study of the "in vitro" susceptibility of 24 Cryptococcus strains to 5 antifungal drugs (amphotericin B, 5 fluorocytosine, miconazole, itraconazole and ketoconazole), was carried out. These strains were grouped according to species, varieties and isolation's origins. The minimum inhibitory concentration (M.I.C.) was determinated by the agar dilution technique in yeast nitrogen base agar with dextrose. The mean geometrical of the M.I.C. values of each group was compared with the others. The results obtained were homogeneous with the only exception of the "non neoformans" strains, in which, higher M.I.C. to 5 fluorocytosine values were detected.