SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study

• Autor(a) principal: Mobile, Rafael Zancan
• Data de Publicação: 2022
• Outros Autores: Warnawin, Stephanie von Stein Cubas, Kojo, Teresinha Keiko, Rodrigues, Jéssica Alline Pereira, Cavilha, Adriana Mendes de Quadros, Zerbinati, Rodrigo Melim, Adamoski, Douglas, Oliveira, Jaqueline Carvalho de, Conzentino, Marcelo Santos, Huergo, Luciano Fernandes, Gradia, Daniela Fiori, Braz-Silva, Paulo Henrique, Schussel, Juliana Lucena
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
• Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/198672
• topic: COVID-19; SARS-CoV-2; Hematopoietic stem cell transplantation; Healthcare workers

This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.