SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/198672 |
Resumo: | This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario. |
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SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort studyCOVID-19SARS-CoV-2Hematopoietic stem cell transplantationHealthcare workersThis prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2022-06-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/19867210.1590/S1678-9946202264039 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e39Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e39Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e391678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/198672/182773Copyright (c) 2022 Rafael Zancan Mobile, Stephanie von Stein Cubas Warnawin, Teresinha Keiko Kojo, Jéssica Alline Pereira Rodrigues, Adriana Mendes de Quadros Cavilha, Rodrigo Melim Zerbinati, Douglas Adamoski, Jaqueline Carvalho de Oliveira, Marcelo Santos Conzentino, Luciano Fernandes Huergo, Daniela Fiori Gradia, Paulo Henrique Braz-Silva, Juliana Lucena Schusselhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessMobile, Rafael Zancan Warnawin, Stephanie von Stein CubasKojo, Teresinha Keiko Rodrigues, Jéssica Alline Pereira Cavilha, Adriana Mendes de Quadros Zerbinati, Rodrigo Melim Adamoski, Douglas Oliveira, Jaqueline Carvalho de Conzentino, Marcelo Santos Huergo, Luciano Fernandes Gradia, Daniela Fiori Braz-Silva, Paulo Henrique Schussel, Juliana Lucena 2022-10-10T13:01:46Zoai:revistas.usp.br:article/198672Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:53:26.780496Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study |
title |
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study |
spellingShingle |
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study Mobile, Rafael Zancan COVID-19 SARS-CoV-2 Hematopoietic stem cell transplantation Healthcare workers |
title_short |
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study |
title_full |
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study |
title_fullStr |
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study |
title_full_unstemmed |
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study |
title_sort |
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study |
author |
Mobile, Rafael Zancan |
author_facet |
Mobile, Rafael Zancan Warnawin, Stephanie von Stein Cubas Kojo, Teresinha Keiko Rodrigues, Jéssica Alline Pereira Cavilha, Adriana Mendes de Quadros Zerbinati, Rodrigo Melim Adamoski, Douglas Oliveira, Jaqueline Carvalho de Conzentino, Marcelo Santos Huergo, Luciano Fernandes Gradia, Daniela Fiori Braz-Silva, Paulo Henrique Schussel, Juliana Lucena |
author_role |
author |
author2 |
Warnawin, Stephanie von Stein Cubas Kojo, Teresinha Keiko Rodrigues, Jéssica Alline Pereira Cavilha, Adriana Mendes de Quadros Zerbinati, Rodrigo Melim Adamoski, Douglas Oliveira, Jaqueline Carvalho de Conzentino, Marcelo Santos Huergo, Luciano Fernandes Gradia, Daniela Fiori Braz-Silva, Paulo Henrique Schussel, Juliana Lucena |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mobile, Rafael Zancan Warnawin, Stephanie von Stein Cubas Kojo, Teresinha Keiko Rodrigues, Jéssica Alline Pereira Cavilha, Adriana Mendes de Quadros Zerbinati, Rodrigo Melim Adamoski, Douglas Oliveira, Jaqueline Carvalho de Conzentino, Marcelo Santos Huergo, Luciano Fernandes Gradia, Daniela Fiori Braz-Silva, Paulo Henrique Schussel, Juliana Lucena |
dc.subject.por.fl_str_mv |
COVID-19 SARS-CoV-2 Hematopoietic stem cell transplantation Healthcare workers |
topic |
COVID-19 SARS-CoV-2 Hematopoietic stem cell transplantation Healthcare workers |
description |
This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-07 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/198672 10.1590/S1678-9946202264039 |
url |
https://www.revistas.usp.br/rimtsp/article/view/198672 |
identifier_str_mv |
10.1590/S1678-9946202264039 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/198672/182773 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e39 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e39 Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e39 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951655759151104 |