SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study

Detalhes bibliográficos
Autor(a) principal: Mobile, Rafael Zancan
Data de Publicação: 2022
Outros Autores: Warnawin, Stephanie von Stein Cubas, Kojo, Teresinha Keiko, Rodrigues, Jéssica Alline Pereira, Cavilha, Adriana Mendes de Quadros, Zerbinati, Rodrigo Melim, Adamoski, Douglas, Oliveira, Jaqueline Carvalho de, Conzentino, Marcelo Santos, Huergo, Luciano Fernandes, Gradia, Daniela Fiori, Braz-Silva, Paulo Henrique, Schussel, Juliana Lucena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/198672
Resumo: This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.
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spelling SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort studyCOVID-19SARS-CoV-2Hematopoietic stem cell transplantationHealthcare workersThis prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2022-06-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/19867210.1590/S1678-9946202264039 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e39Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e39Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e391678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/198672/182773Copyright (c) 2022 Rafael Zancan Mobile, Stephanie von Stein Cubas Warnawin, Teresinha Keiko Kojo, Jéssica Alline Pereira Rodrigues, Adriana Mendes de Quadros Cavilha, Rodrigo Melim Zerbinati, Douglas Adamoski, Jaqueline Carvalho de Oliveira, Marcelo Santos Conzentino, Luciano Fernandes Huergo, Daniela Fiori Gradia, Paulo Henrique Braz-Silva, Juliana Lucena Schusselhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessMobile, Rafael Zancan Warnawin, Stephanie von Stein CubasKojo, Teresinha Keiko Rodrigues, Jéssica Alline Pereira Cavilha, Adriana Mendes de Quadros Zerbinati, Rodrigo Melim Adamoski, Douglas Oliveira, Jaqueline Carvalho de Conzentino, Marcelo Santos Huergo, Luciano Fernandes Gradia, Daniela Fiori Braz-Silva, Paulo Henrique Schussel, Juliana Lucena 2022-10-10T13:01:46Zoai:revistas.usp.br:article/198672Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:53:26.780496Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
title SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
spellingShingle SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
Mobile, Rafael Zancan
COVID-19
SARS-CoV-2
Hematopoietic stem cell transplantation
Healthcare workers
title_short SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
title_full SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
title_fullStr SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
title_full_unstemmed SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
title_sort SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
author Mobile, Rafael Zancan
author_facet Mobile, Rafael Zancan
Warnawin, Stephanie von Stein Cubas
Kojo, Teresinha Keiko
Rodrigues, Jéssica Alline Pereira
Cavilha, Adriana Mendes de Quadros
Zerbinati, Rodrigo Melim
Adamoski, Douglas
Oliveira, Jaqueline Carvalho de
Conzentino, Marcelo Santos
Huergo, Luciano Fernandes
Gradia, Daniela Fiori
Braz-Silva, Paulo Henrique
Schussel, Juliana Lucena
author_role author
author2 Warnawin, Stephanie von Stein Cubas
Kojo, Teresinha Keiko
Rodrigues, Jéssica Alline Pereira
Cavilha, Adriana Mendes de Quadros
Zerbinati, Rodrigo Melim
Adamoski, Douglas
Oliveira, Jaqueline Carvalho de
Conzentino, Marcelo Santos
Huergo, Luciano Fernandes
Gradia, Daniela Fiori
Braz-Silva, Paulo Henrique
Schussel, Juliana Lucena
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mobile, Rafael Zancan
Warnawin, Stephanie von Stein Cubas
Kojo, Teresinha Keiko
Rodrigues, Jéssica Alline Pereira
Cavilha, Adriana Mendes de Quadros
Zerbinati, Rodrigo Melim
Adamoski, Douglas
Oliveira, Jaqueline Carvalho de
Conzentino, Marcelo Santos
Huergo, Luciano Fernandes
Gradia, Daniela Fiori
Braz-Silva, Paulo Henrique
Schussel, Juliana Lucena
dc.subject.por.fl_str_mv COVID-19
SARS-CoV-2
Hematopoietic stem cell transplantation
Healthcare workers
topic COVID-19
SARS-CoV-2
Hematopoietic stem cell transplantation
Healthcare workers
description This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/198672
10.1590/S1678-9946202264039
url https://www.revistas.usp.br/rimtsp/article/view/198672
identifier_str_mv 10.1590/S1678-9946202264039
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/198672/182773
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e39
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e39
Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e39
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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