Factors associated with the development of leprosy in Brazilian contacts: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/203534 |
Resumo: | People who interact with leprosy patients in their environment, neighborhood, family, or social relationships are at risk to develop the disease. This systematic review investigated the risk and protective factors associated with the development of leprosy in Brazilian contacts. The studies were found in Cochrane Library, PubMed (MEDLINE), Embase, Virtual Health Library, grey literature and hand search until July 2021. The study selection, data extraction and quality assessment were independently performed by two investigators. The quality assessment was performed using the Newcastle-Ottawa Scale (NOS). This review was registered in PROSPERO (CRD42020160680). Seventeen articles fulfilled the inclusion criteria (n=544). The immunological and molecular factors, such as Anti-phenolic Glycolipid Antibodies (Anti-PGL-1) seropositivity, negative Mitsuda test, absence of Bacillus Calmette-Guérin (BCG) scar, positive Polymerase Chain Reaction (PCR) in blood; age and race; conviviality, education, contact time and type of contact, as well as elements related to the index case (bacilloscopic index; genetic conditions, family relationships), and some combined factors were shown to be relevant risk factors associated with the development of the disease in Brazilian leprosy contacts. The protective factors reported were the presence of one or more BCG scars, positive Mitsuda test, and education level. All selected studies were considered of high quality according to NOS. The knowledge of disease-related risk and protective factors provides the scientific basis for decision-making in the management of the disease in leprosy contacts. |
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Factors associated with the development of leprosy in Brazilian contacts: a systematic reviewLeprosyRisk factorsProtective factorsPublic health surveillanceSystematic reviewPeople who interact with leprosy patients in their environment, neighborhood, family, or social relationships are at risk to develop the disease. This systematic review investigated the risk and protective factors associated with the development of leprosy in Brazilian contacts. The studies were found in Cochrane Library, PubMed (MEDLINE), Embase, Virtual Health Library, grey literature and hand search until July 2021. The study selection, data extraction and quality assessment were independently performed by two investigators. The quality assessment was performed using the Newcastle-Ottawa Scale (NOS). This review was registered in PROSPERO (CRD42020160680). Seventeen articles fulfilled the inclusion criteria (n=544). The immunological and molecular factors, such as Anti-phenolic Glycolipid Antibodies (Anti-PGL-1) seropositivity, negative Mitsuda test, absence of Bacillus Calmette-Guérin (BCG) scar, positive Polymerase Chain Reaction (PCR) in blood; age and race; conviviality, education, contact time and type of contact, as well as elements related to the index case (bacilloscopic index; genetic conditions, family relationships), and some combined factors were shown to be relevant risk factors associated with the development of the disease in Brazilian leprosy contacts. The protective factors reported were the presence of one or more BCG scars, positive Mitsuda test, and education level. All selected studies were considered of high quality according to NOS. The knowledge of disease-related risk and protective factors provides the scientific basis for decision-making in the management of the disease in leprosy contacts.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2022-10-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/20353410.1590/S1678-9946202264055Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e55Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e55Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e551678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/203534/187488Copyright (c) 2022 Edilamar Silva de Alecrin, Ana Laura Grossi de Oliveira, Nathália Sernizon Guimarães, Sandra Lyon, Maria Auxiliadora Parreiras Martins, Manoel Otávio da Costa Rochahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessAlecrin, Edilamar Silva de Oliveira, Ana Laura Grossi deGuimarães, Nathália Sernizon Lyon, Sandra Martins, Maria Auxiliadora Parreiras Rocha, Manoel Otávio da Costa 2022-10-14T17:43:03Zoai:revistas.usp.br:article/203534Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:54:10.240234Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Factors associated with the development of leprosy in Brazilian contacts: a systematic review |
title |
Factors associated with the development of leprosy in Brazilian contacts: a systematic review |
spellingShingle |
Factors associated with the development of leprosy in Brazilian contacts: a systematic review Alecrin, Edilamar Silva de Leprosy Risk factors Protective factors Public health surveillance Systematic review |
title_short |
Factors associated with the development of leprosy in Brazilian contacts: a systematic review |
title_full |
Factors associated with the development of leprosy in Brazilian contacts: a systematic review |
title_fullStr |
Factors associated with the development of leprosy in Brazilian contacts: a systematic review |
title_full_unstemmed |
Factors associated with the development of leprosy in Brazilian contacts: a systematic review |
title_sort |
Factors associated with the development of leprosy in Brazilian contacts: a systematic review |
author |
Alecrin, Edilamar Silva de |
author_facet |
Alecrin, Edilamar Silva de Oliveira, Ana Laura Grossi de Guimarães, Nathália Sernizon Lyon, Sandra Martins, Maria Auxiliadora Parreiras Rocha, Manoel Otávio da Costa |
author_role |
author |
author2 |
Oliveira, Ana Laura Grossi de Guimarães, Nathália Sernizon Lyon, Sandra Martins, Maria Auxiliadora Parreiras Rocha, Manoel Otávio da Costa |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Alecrin, Edilamar Silva de Oliveira, Ana Laura Grossi de Guimarães, Nathália Sernizon Lyon, Sandra Martins, Maria Auxiliadora Parreiras Rocha, Manoel Otávio da Costa |
dc.subject.por.fl_str_mv |
Leprosy Risk factors Protective factors Public health surveillance Systematic review |
topic |
Leprosy Risk factors Protective factors Public health surveillance Systematic review |
description |
People who interact with leprosy patients in their environment, neighborhood, family, or social relationships are at risk to develop the disease. This systematic review investigated the risk and protective factors associated with the development of leprosy in Brazilian contacts. The studies were found in Cochrane Library, PubMed (MEDLINE), Embase, Virtual Health Library, grey literature and hand search until July 2021. The study selection, data extraction and quality assessment were independently performed by two investigators. The quality assessment was performed using the Newcastle-Ottawa Scale (NOS). This review was registered in PROSPERO (CRD42020160680). Seventeen articles fulfilled the inclusion criteria (n=544). The immunological and molecular factors, such as Anti-phenolic Glycolipid Antibodies (Anti-PGL-1) seropositivity, negative Mitsuda test, absence of Bacillus Calmette-Guérin (BCG) scar, positive Polymerase Chain Reaction (PCR) in blood; age and race; conviviality, education, contact time and type of contact, as well as elements related to the index case (bacilloscopic index; genetic conditions, family relationships), and some combined factors were shown to be relevant risk factors associated with the development of the disease in Brazilian leprosy contacts. The protective factors reported were the presence of one or more BCG scars, positive Mitsuda test, and education level. All selected studies were considered of high quality according to NOS. The knowledge of disease-related risk and protective factors provides the scientific basis for decision-making in the management of the disease in leprosy contacts. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/203534 10.1590/S1678-9946202264055 |
url |
https://www.revistas.usp.br/rimtsp/article/view/203534 |
identifier_str_mv |
10.1590/S1678-9946202264055 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/203534/187488 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e55 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e55 Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e55 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951659379884032 |